AHA Funds Three Research Centers to Study Generation of Cardiac Muscle Cells


April 14, 2009

April 14, 2009 - Three research centers have been awarded funding from the American Heart Association, with support from the Jon Holden DeHaan Foundation, to study the development and mechanisms of generating new cardiac muscle cells.

The centers will be conducting studies over the next four years to ultimately determine how regeneration of those cells can help improve outcomes for heart attack and heart failure patients.

The grants, totaling $6 million, have been awarded to the following facilities, which will each become home to an American Heart Association-Jon Holden DeHaan Foundation Cardiac Myogenesis Research Center:

-- University of Pennsylvania, Philadelphia, PA. - Center Director:

Jonathan Epstein, M.D.

-- University of Texas Southwestern Medical Center, Dallas, TX -

Center Director: Eric Olson, Ph.D.

-- University of Minnesota, Minneapolis, MN - Center Director: Doris

Taylor, Ph.D.

Each center will undertake a number of basic science research projects specifically looking at cardiac myocytes, or heart cell muscles, to learn more about how those cells biologically develop, integrate and work. Ideally, findings from this research will lead to new ways for treating various forms of heart disease, including heart attacks, congenital heart disease and heart failure.

Some of the research will focus on developing methods to identify stems cells from the heart or other organs, such as bone marrow, to give back to the patient in a way that will sustain long-lasting recovery of cardiac function. The research will build the foundation for future use of adult stem cells for regenerating and repairing heart muscle, as well as for developing new therapies and drugs in the fight against heart disease.

Thee awards are effective April 1, 2009, and will be funded through March 31, 2012.

For more information: www.americanheart.org