Feature | May 16, 2013

Nearly 50 Percent of Patients With Cardiac Device Infections Don’t Survive Beyond Three Years

New study of Medicare patients presented at 2013 Heart Rhythm Society Meeting

May 16, 2013 — The incremental mortality in implantable pacemaker and defibrillator recipients who experience a device infection, compared to patients without device infection, is substantial and persists for at least three years after index hospitalization with infection. These are the key findings of a retrospective cohort study of 200,219 Medicare fee-for-service patients undergoing cardiac device procedures, with and without infection, that were presented today by M. Rizwan Sohail, M.D., a researcher from the Mayo Clinic divisions of infectious diseases and cardiovascular diseases, at Heart Rhythm 2013, the Heart Rhythm Society’s 34th Annual Scientific Sessions.

Previously, Sohail and his collaborators have reported that patients with cardiac device infections experience a two-fold increase in the mortality rate one year after device implantation, compared to patients without an infection. In this new study, Sohail and collaborators looked at the long-term mortality three years after the device procedure in 200,219 Medicare beneficiaries that underwent permanent pacemaker and defibrillator procedures between Jan. 1, 2007 and Dec. 31, 2007, including 5,817 patients with cardiac device infections.

Key findings of the study included:

  • The 15-29 percent higher mortality seen in patients with cardiac device infections, compared to patients without cardiac device infections, continued for at least three years.
  • Three years after the procedure:
    • Patients with pacemakers (PM) infection had 54 percent mortality, vs. 33 percent without PM infection (P<0.001)
    • Patients with ICD infection had 48 percent mortality vs. 32 percent without ICD infection (P<0.001)
    • Patients with CRT-D infections had a 51 percent mortality vs. 37 percent without CRT-D infection (p<0.001)
  • For PM patients with a device infection, the incremental mortality associated with device infection continues to increase for at least three years.

“It is well known that cardiac device therapies such as pacemakers, implanted cardioverter-defibrillators (ICDs), and cardiac resynchronization therapy/defibrillators (CRT-Ds) can reduce morbidity and mortality in appropriately selected patients,” said Sohail, “Unfortunately, these benefits can be significantly reduced, if the implantation/replacement procedure is complicated by a device infection. The focus of this study was to better understand the long-term mortality associated with CIED infections, stratified for different cardiac device types.”

This study was funded by Tyrx Inc., maker of implantable combination drug/device products focused on infection control for implantable electrophysiology devices.

For more information: www.HeartDeviceInfection.com

Related Content

CardioKinetix, Parachute device, Heart Failure device therapy

The CardioKinetix Parachute device implant shown deployed in the left ventricle of a heart failure patient. The device helps remodel the ventricle to improve the heart's ability to pump blood more efficiently. 

Feature | Heart Failure| September 29, 2016 | Abha Mishra
New cardiovascular device therapies for atrial fibrillation (AF) and heart failure (HF) are rapidly evolving with the
Infinix 4D CT

Toshiba's Infinix 4D CT, which combines CT with angiography in the interventional lab.

Feature | Angiography| September 28, 2016 | Tom Watson BS, RCVT, Clinical Analyst, MD Buyline
One of the more significant advancements for interventional X-ray (IXR) in the past few years has been a significantl
European Heart Rhythm Association, EHRA White Book 2016, EP Europace supplement, cardiac rhythm device use, Europe
News | EP Lab| September 27, 2016
In August, the European Heart Rhythm Association (EHRA) and EP Europace journal announced the release of the supplement...
Sponsored Content | Videos | Inventory Management| September 21, 2016
With bundled payments putting increased pressure on hospitals to manage supply costs while providing quality patient
Medtronic, CRT, cardiac resynchroniazation therapy devices, heart failure, medication adherence, retrospective analysis, HFSA 2016
News | Heart Failure| September 20, 2016
Medtronic plc announced the results of an analysis that reveals patients increasingly adhere to heart failure...
don woodlock, GE Healthcare, EP CVIS, electrophyiology
Sponsored Content | Webinar | Cardiac PACS| September 16, 2016
Cardiac rhythm management (CRM) data is becoming increasingly important in the management of patients with implantabl
EBR Systems, FDA, WiSE Technology, Wireless Stimulation Endocardially, SOLVE-CRT study

The WiSE CRT System uses a tiny implant in the left ventricle to synchronize the heart, overcoming limitations of traditional cardiac resynchronization therapy (CRT) in heart failure patients. Graphic courtesy of Business Wire.

News | Cardiac Resynchronization Therapy Devices (CRT)| September 15, 2016
EBR Systems Inc. announced the U.S. Food and Drug Administration (FDA) has granted an Investigational Device Exemption...
Sponsored Content | Videos | Heart Failure| September 02, 2016
The Respicardia Remede System is a pacemaker-like implantable device designed to improve cardiovascular health by res
Respicardia, Remede, pacemaker for sleep apnea, central sleep apnea treatment

The Respicardia Remede System is a pacemaker-like implantable device designed to improve cardiovascular health by restoring natural breathing during sleep in patients with central sleep apnea.

News | Heart Failure| September 02, 2016
September 2, 2016 — Results from an international, randomized study show that an implanted nerve stimulator significa
Overlay Init