Feature | June 09, 2014

Stem Cell Stimulating Therapy Saves Heart Attack Patients

SPECT study shows how early administration of the treatment aids survival of those recovering from myocardial infarction

June 9, 2014 — Researchers at the Society of Nuclear Medicine and Molecular Imaging’s 2014 Annual Meeting (SNMMI) revealed how a protein encourages the production of stem cells that regenerate damaged tissues of the heart following an acute attack (myocardial infarction). They further assert that it has a better chance of working if provided early in treatment. This was confirmed by molecular imaging, which captured patients’ improved heart health after therapy. 

If given after a heart attack, granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow stem cells that turn down the collateral damage of cell death that occurs after acute myocardial infarction. Other research has shown G-CSF having a beneficial impact on left ventricle ejection fraction, a measurement of how powerfully the heart is pumping oxygenated blood back into the aorta and the rest of the body with each beat. The objective of this study was to find out how beneficial the stem cell–stimulating therapy would be if administered early during standard treatment. Early prescription of G-CSF happens to strengthen its effect immediately and after follow up.

“Previous studies have shown that giving G-CSF to unselected heart attack patients failed to satisfactorily improve their condition, but G-CSF may potentially be beneficial if given earlier than 37 hours following myocardial infarction and coronary intervention,” said Takuji Toyama, M.D., the study’s principal researcher from the division of cardiology at Gunma Prefectural Cardiovascular Center in Maebashi, Japan. “This study shows that the first intravenous drip infusion of G-CSF during treatment just after hospitalization was able to rescue our patients. I am confident that with additional data from a forthcoming clinical trial, this protocol can be adopted as a standard of practice.”

For this study, 40 consecutive patients with acute myocardial infarction were given either G-CSF therapy or saline intravenously for a total of five days beginning during a selected minimally invasive treatment, otherwise known as percutaneous cardiac intervention. Results of one year’s worth of single photo emission computed tomography (SPECT) stress tests nailed how earlier start of G-CSF therapy in heart attack patients improves blood flow, access to essential energy and overall cardiac function. 

Coronary heart disease caused one out of every six fatalities in the U.S. in 2010, according to 2014 statistics from the American Heart Association. An estimated 620,000 Americans suffered a first heart attack, and 295,000 had a recurrent episode. Collectively, heart attacks occur about once every 34 seconds. Coronary events cause about 379,559 deaths each year.

For more information: www.snmmi.org.

 

 

Related Content

NorthStar Medical Radioisotopes, approval, routine production, Molybdenum-99, Mo-99, University of Missouri Research Reactor, MURR
News | Radiopharmaceuticals and Tracers| August 31, 2015
NorthStar Medical Radioisotopes LLC has received approval to begin routine production of molybdenum-99 (Mo-99) at the...
Navidea, Mass General, Tc99m-tilmanocept, vulnerable plaque, cardiovascular disease, Harvard
News | Radiopharmaceuticals and Tracers| July 30, 2015
Navidea Biopharmaceuticals Inc. announced plans to move forward with a joint study of the ability of Tc99m-tilmanocept...
MSCs, stem cells, end-stageheart failure, retrograde, coronary sinus,
News | Stem Cell Therapies| July 29, 2015
A new clinical trial to test how a high dose of stem cells delivered via a method called retrograde coronary sinus...
NeoStem, PreSERVE study, AMI, ACC.15, NBS10, CD34 stem cells
Feature | Heart Failure| July 17, 2015
NeoStem Inc. presented updated efficacy and safety results from the one-year follow-up for its Phase 2 PreSERVE study...
Medraysintell, nuclear medicine, World Market Report, radiopharmaceuticals
News | Nuclear Imaging| July 06, 2015
Medraysintell released its updated World Market Report and Directory on Nuclear Medicine, Edition 2015, in late June,...
nuclear medicine diagnostic market, North America, PET, SPECT, Mordor
News | Nuclear Imaging| June 29, 2015
The Global Nuclear Medicine Diagnostics Market report from Mordor Intelligence revealed that North America accounts for...
Siemens, MES contract, William Osler Health System, Ontario, Canada
News | Cardiac Imaging| June 26, 2015
Canadian hospital William Osler Health System (Osler), based in Ontario, has awarded Siemens Healthcare a Managed...
fibrin, MSCs, stem cells, heart failure, Antoni Bayes-Genis, umbilical cord
Feature | Heart Failure| June 24, 2015
To date, the only definitive treatment for heart failure — an organ transplant — is hampered by both the limited number...
Siemens, SNMMI 2015, Biograph RT Pro, Symbia Evo, syngo.via for MI
News | Nuclear Imaging| June 11, 2015
At the 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), June 6-10 at the Baltimore...
GE Healthcare, FASTlab 2, FDG Duo, GENtrace cyclotron, PET imaging

FASTlab 2 with FDG Duo cassette image courtesy of GE Healthcare

Technology | June 08, 2015
GE Healthcare announced that it has created a solution to make positron emission tomography (PET) tracers for...
Overlay Init