CardioDx Announces Medicare Coverage for Corus CAD Gene Expression Test

Tests aids in diagnosis of obstructive coronary artery disease, lower costs of diagnosis


August 9, 2012

Palmetto GBA, a national contractor that administers Medicare benefits, established coverage in August 2012 for CardioDx Inc.’s Corus CAD gene expression test for the evaluation of patients presenting with typical and atypical symptoms suggestive of coronary artery disease (CAD).

With a simple blood draw, Corus CAD can safely, accurately and conveniently help primary care clinicians and cardiologists assess whether or not a stable non-diabetic patient’s symptoms are due to obstructive CAD, enabling many patients to avoid unnecessary invasive testing and exposure to imaging-related radiation risks or imaging agent intolerance. The test has been clinically validated in multiple independent patient cohorts, including two prospective, multicenter U.S. trials, PREDICT and COMPASS. Additionally, a retrospective, multicenter chart review study and the prospective IMPACT trial at Vanderbilt University demonstrated that Corus CAD use yielded significant and clinically relevant changes in patient management decisions in both primary care and cardiology settings.

Studies have shown that typical and atypical presentations of stable chest pain account for up to 2 percent of outpatient office visits each year in the United States, but as many as 62 percent of stable patients who undergo elective invasive angiographic procedures are found to have no obstructive coronary artery blockage, despite broad usage of prior noninvasive imaging. The authors of a 2010 New England Journal of Medicine study of nearly 400,000 coronary angiography patients concluded that current modalities used to identify patients for elective invasive angiography to diagnose obstructive CAD have limitations, and that better methods are needed for patient risk stratification.

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