Dabigatran Offers Alternative to Warfarin
Dabigatran is an alternative to warfarin to help prevent dangerous blood clots in patients with atrial fibrillation, according to guidelines from the American College of Cardiology, American Heart Association and the Heart Rhythm Society.
Dabigatran is useful as an alternative to warfarin to prevent stroke and blood clots in patients with either paroxysmal (recurrent episodes that stop after seven days) or permanent (an on-going episode) atrial fibrillation. It is also useful in patients with risk factors for stroke or blood clotting who do not have a prosthetic heart valve, significant heart valve disease, severe renal failure or advanced liver disease.
Warfarin, an anticlotting drug used since the 1950s, requires patients to have regular testing to monitor its effectiveness and dosage adjustment.
In December 2010 the atrial fibrillation guidelines said that a combination of aspirin and clopidogrel might be considered to prevent stroke or other types of blood clots in patients with atrial fibrillation who are poor candidates for warfarin.