Eplerenone Reduces Mortality Risk in Mild Heart Failure Patients
Eplerenone (Inspra) is a steroid nucleus-based mineralcorticoid receptor (MR) antagonist with a higher degree of selectivity than spironolactone. The drug, by Pfizer, was compared to placebo and standard therapy in heart failure patients with mild symptoms in the EMPHASIS-HF trial.
The trial demonstrated a significant reduction in risk of cardiovascular death or heart failure hospitalizations.
In the trial, there was a higher incidence of hyperkalemia (elevated potassium) among patients assigned to eplerenone compared to placebo. However, hypokalemia (low potassium) was lower in the eplerenone group.
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