Biodegradable Sealant Patch Prevents Bleeding During Cardiovascular Surgery


April 5, 2010
The TachoSil patch being used during an aortic valve replacement.

An absorbable fibrin sealant patch for use in cardiovascular surgery prevents mild and moderate bleeding from small blood vessels, when standard surgical techniques are ineffective or impractical.

The TachoSil is a ready-to-use surgical patch composed of a dry collagen sponge made from horse tendons, and coated with fibrinogen and thrombin. At the site of a wound, the two proteins, through a series of chemical reactions, produce fibrin, a stringy, white, insoluble protein that allows a clot to form.
The patch is biodegradable and breaks down inside the body within four to six months. TachoSil is not intended for use within blood vessels.

The plasma used to manufacture TachoSil is collected from U.S. donors who have been screened and tested for diseases transmitted by blood. The fibrinogen and thrombin used in the surgical patch undergo additional manufacturing processes to remove impurities, including blood-borne viruses. The collagen taken from horse tendons undergoes a separate step to remove impurities, including equine viruses.

The FDA cleared the product in March 2010.

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