Genetic Test Detects Dilated Cardiomyopathy
A genetic test to detect familial dilated cardiomyopathy (DCM), the FAMILION DCM Test, allows earlier detection and therapy to help slow disease progression.
The test expands the FAMILION family of genetic tests to six index tests used to diagnose or confirm familial heart disease offered by PGxHealth, a division of Clinical Data Inc.
In 2009, practice guidelines published by the Heart Failure Society of America (HFSA) supported the utilization of genetic testing for patients and their family members suspected of carrying mutations causative of DCM. The company said its FAMILION DCM Test sequences the 12 genes most commonly associated with DCM (LMNA, ANKRD1, TNNC1, SCN5A, TPM1, MYBPC3, ACT1, LDB3, PLN, MYH7, TNNT2, TNNI3). In addition, the test is the only DCM panel to include SCN5A and ANKRD1, two genes known to account for 5 percent of gene mutations in familial DCM patients.
The test was cleared by the FDA in November 2009.