News | August 20, 2007

Evidence of WHR’s Link to Cardiovascular Disease Grows

August 21, 2007 - Research conducted at the University of Texas Southwestern Medical Center in Dallas and appearing in the August 21, 2007 issue of the Journal of the American College of Cardiology (JACC) suggests that an increase of several inches to the waistline markedly increases the risk of unhealthy plaque build-up in the arteries of the heart and the rest of the body.

According to the study, the relationship of the waist measurement to the hip ratio (WHR) was much more closely tied to early, hidden signs of heart disease than other common measures of obesity, such as body mass index (BMI) or the waist circumference alone.

“In our thirties and forties, we often gain three to four inches in the midsection,” said James A. de Lemos, M.D., F.A.C.C., a professor of medicine and director of the Coronary Care Unit at the University of Texas Southwestern Medical Center. “It’s a day-to-day, meal-to-meal battle, but it’s worth fighting. Even a small pot belly puts us at higher risk when compared to a flat tummy.”

For the study, Dr. de Lemos and his colleagues examined data from the ongoing Dallas Heart Study, which is evaluating risk factors for heart disease in a large, multiethnic, urban population with a median age of 45. The new substudy focused on a group of 2,744 participants who had noninvasive imaging tests to look for early signs of plaque build-up in the arteries, which signals an increased risk of developing cardiovascular disease later in life.

Electron-beam computed tomography (EBCT) was used to identify calcium deposits in the arteries of the heart that indicate the onset of atherosclerosis. Magnetic resonance imaging (MRI) was used to look for early signs of atherosclerosis in the walls of the aorta.

Researchers then examined the relationship between body shape and early signs of arterial disease. They found that the likelihood of calcium being found in the arteries of the heart grew in direct proportion to increases in the waist-to-hip ratio (WHR). In addition, when they divided the WHR into five groups from smallest to largest, they found that people with the largest WHR were nearly twice as likely to have calcium deposits in their coronary arteries as those with the smallest WHR. The likelihood of atherosclerotic plaque in the aorta was three times as high in those with the largest WHR as compared to the smallest.

The relationship between WHR and arterial plaque remained strong even after other risk factors, such as blood pressure, diabetes, age, smoking and high cholesterol levels were taken into account.

Using the waist-to-hip measurement to gauge cardiovascular risk has certain clinical advantages, said Raimund Erbel, M.D., West German Heart Center Essen. “The WHR can be easily measured, taking only a few moments and giving more precise information on the presence of coronary artery calcium than BMI or waist circumference,” Dr. Erbel said. “In addition, although BMI is used more often, it does not identify patients with central obesity, which seems to be related to the metabolic syndrome, insulin resistance and abnormal cholesterol levels. However, most important is that other measures of obesity did not discriminate beyond traditional risk factors, whereas WHR did.”

For more information: www.acc.org

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