Feature | May 15, 2014

Linking Vascular Inflammation to Obesity, Atherosclerosis

May 15, 2014 — A clinical study in The Journal of Experimental Medicine shows that I?B kinase ? (IKK?) functions in smooth muscle cells to regulate vascular inflammatory responses and atherosclerosis development.

Inflammatory responses are the driving force of atherosclerosis, a process that involves the hardening and thickening of artery walls due to excess fatty deposits. IKK? is a central coordinator of inflammatory responses that has been implicated in vascular diseases, but its role in atherosclerosis has been unclear.

Now, Changcheng Zhou and colleagues from the University of Kentucky show that deficiency of IKK? in smooth muscle cells decreases vascular inflammation and atherosclerosis development in mice. Surprisingly, the lack of IKK? also blocks the differentiation of fat cells and causes an accumulation of body fat precursor cells, thus protecting the animals from diet-induced obesity. These novel findings suggest that the kinase acts as a regulator of fat cell differentiation. The use of IKK? inhibitors may therefore provide an innovative treatment for atherosclerosis, obesity, and metabolic disorders.

Sui, Y., et al. 2014. J. Exp. Med.doi:10.1084/jem.20131281

For more information: www.jem.org

Related Content

News | Cardiac Diagnostics| June 24, 2016
Measuring antibody levels in the blood could be used to detect a person’s heart attack risk after researchers, part-...
Zoll LifeVest wearable defibrillator, WEARIT-II Registry results, CardioStim EuroPace 2016
News | Defibrillator Monitors| June 21, 2016
Zoll Medical Corp. announced that patients experience a high one-year survival rate following use of the LifeVest...
News | Implantable Cardioverter Defibrillators (ICD)| June 14, 2016
Medtronic plc announced results from several feasibility studies evaluating a new approach to implantable cardioverter...
hypertrophic cardiomyopathy, HCM, strain echocardiography, risk assessment, ASE 2016
News | Cardiovascular Ultrasound| June 13, 2016
After following a large sub-set of patients, researchers found that by using strain echocardiography they could...
ASE 2016, Mayo Clinic study, echocardiography, aortic flow rate, patient risk stratification
News | Cardiovascular Ultrasound| June 13, 2016
Researchers from Mayo Clinic believe they have found a better way to risk stratify some of their most fragile patients.
hemmorhagic stroke, blood pressure management, ATACH II trial, NINDS

Brain scan showing damage caused by bleeding during a hemorrhagic stroke. Image courtesy of Adnan I Qureshi, M.D., University of Minnesota.

News | Stroke| June 09, 2016
June 9, 2016 — An international stroke study
Medtronic, Micra TPS pacemaker, Global Clinical Trial, Cardiostim 2016
News | Pacemakers| June 09, 2016
Medtronic plc announced new results from the Medtronic Micra Transcatheter Pacing System (TPS) Global Clinical Trial in...
McKesson, iPad, CVIS, ECG mobile viewer

Dynamic ECG waveforms displayed on an iPad using McKesson's mobile ECG viewer, which directly connects to the hospital's cardiovascular information system or ECG management system. This technology can help speed triage of STEMI patients, allowing diagnosis anywhere, rather than requiring cardiologists to walk down to an emergency department or drive into the hospital to view the ECG.

Feature | Mobile Devices| June 09, 2016 | Dave Fornell
The ubiquitous smartphone has found its way into the pockets of nearly every clinician and patient in recent years an
Vital Connect, BePATIENT, BeVITAL remote monitoring system, HealthPatch MD

Vital Connect's HealthPatch MD wearable sensor, part of the BeVITAL remote monitoring system.

Technology | Remote Monitoring| June 08, 2016
Vital Connect Inc., developer of wearable biosensor technologies, and BePATIENT, a startup that develops patient-...
heart failure, muscle bleeding, British Cardiovascular Conference, MRI
News | Heart Failure| June 08, 2016
The amount a heart ‘bleeds’ following a heart attack can predict the severity of future heart failure, according to...
Overlay Init