Feature | November 04, 2013

Removing Blood Clots During PCI Does Not Improve Outcomes

November 4, 2013 – According to a new study, aspirating blood clots does not significantly reduce microvascular obstruction or reduce the risk of death in patients with non-ST-elevation myocardial infarction (NSTEMI), when compared to standard percutaneous coronary intervention (PCI) without thrombectomy. Findings from the TATORT-NSTEMI clinical trial were presented at the 25th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium.

Thrombus aspiration, or the removal of blood clots, is frequently used for patients with ST-elevation myocardial infarction (STEMI, the most serious type of heart attack). However, there are no randomized data to unequivocally support thrombectomy in patients with NSTEMI. TATORT-NSTEMI is a prospective, controlled, multicenter, randomized trial that compared adjunctive thrombectomy to conventional PCI in patients with thrombus containing lesions.

The trial randomized 460 patients in a 1:1 fashion to thrombectomy and standard PCI. The primary endpoint was the extent of microvascular obstruction assessed by cardiac magnetic resonance (CMR) within four days after randomization and measured by the percentage of the left ventricle (LV). Clinical endpoints including death, myocardial reinfarction, target vessel revascularization and new congestive heart failure were analyzed at six months.

Microvascular obstruction was not different between the thrombectomy and standard PCI groups (1.7 percent LV vs. 1.6 percent LV, respectively, p=0.65).

Similarly, no significant differences were observed in infarct size, myocardial salvage index, or angiographic parameters such as blush grade or TIMI flow grade.

Clinical follow up at six months also revealed no differences in the combined clinical endpoint between the thrombectomy and the standard PCI group (p=0.85).

“TATORT-NSTEMI is the first randomized trial in NSTEMI testing the efficacy of additional manual aspiration thrombectomy,” said lead investigator Holger Thiele, M.D. Thiele is Deputy Director of the University of Leipzig Heart Center in Leipzig, Germany.

“Aspiration thrombectomy in patients with NSTEMI undergoing early PCI in thrombus containing lesions does not reduce the extent of no-reflow in comparison to standard PCI without thrombectomy.”

The TATORT-NSTEMI trial was funded by unrestricted grants from Terumo Europe and Lilly Germany. Thiele reported research funding from Terumo Europe, Lilly Germany, Maquet Cardiovascular and Teleflex Medical.

For more information: www.crf.org and www.tctconference.com

Related Content

pediatric echocardiograms, cardiovascular ultrasound, therapy dog impact, animal-assisted therapy, Human Animal Bond Research Initiative, HABRI
News | Cardiovascular Ultrasound| October 25, 2016
The Human Animal Bond Research Initiative (HABRI) announced it has awarded a $44,000 grant to Duke University School of...
medicare bundled cardiac payments, CMS cardiology payments
Feature | Business| October 24, 2016 | By John W. Meyer, MPH, FACHE
(Editor’s note: This is the second part of a two-part series on the proposed Medicare five-year demonstration for
bioresorbable stents, bioabsorbable stents, visualizing the Absorb BVS, dissolving stent, disappearing stent on IVUS and OCT

A comparison of how the Abbott Absorb BVS appears with intravascular ultrasound (IVUS) on the left, and optical coherence tomography (OCT) of the right. The stent is difficult to visualize and sizing is critical, so both modalities can help in bioresorbable stent measurements and to confirm stent apposition. Left image from the Volcano IVUS system and the right image from St. Jude Medical's OCT system


Feature | Stents Bioresorbable| October 20, 2016 | Dave Fornell
There has been a lot of interest in the interventional community regarding the Abbott Absorb Bioresorbable Vascular S
Avinger, Pantheris atherectomy catheter, OCT, Lumivascular technology, expanded FDA indication, diagnostic imaging device
News | Atherectomy Devices| October 20, 2016
Avinger Inc. recently announced that the company has received expanded indications from the U.S. Food and Drug...
St. Jude Medical, ADO II AS trial, congenital heart disease, PDA, Amplatzer Duct Occluder II AS
News | Congenital Heart| October 19, 2016
St. Jude Medical Inc. announced the launch of the ADO II AS (AMPLATZER Duct Occluder II Additional Sizes) pediatric...
recall, alligator retrieval device, X-Celerator hydrophilic guidewire, UltraFlow flow directed micro catheters, Marathon flow directed micro catheters
News | Cath Lab| October 18, 2016
Medtronic plc announced last week that it has notified customers of a voluntary recall of certain lots of its Pipeline...
Inventory management, Cardinal, RFID inventory tracking, cath lab inventory
Sponsored Content | Whitepapers | Inventory Management| October 18, 2016
As healthcare moves into the era of bundled payments, providers need to be especially focused on ensuring delivery of
angioseal, angio-seal, terumo, St. Jude, vascular closure devices
News | Vascular Closure Devices| October 18, 2016
October 18, 2016 — Abbott and St. Jude Medical Inc.
Lantheus, flurpiridaz F-18, myocardial perfusion imaging, MPI, cardiac stress testing, ASNC 2016
News | Radiopharmaceuticals and Tracers| October 17, 2016
Lantheus Holdings Inc. announced in late September that sub-analysis data from the first Phase 3 study of flurpiridaz F...
Overlay Init