News | March 26, 2010

Genetic Testing Reveals Predisposition to Heart Disease

March 24, 2010 — Several genes are associated with heart disease, stroke, and high blood pressure, and can determine whether people may have predisposition to these conditions, according to genetics research.

In 2009, in one of the largest studies of its kind, researchers associated with the Myocardial Infarction Genetics Consortium uncovered nine genetic variants or mutations associated with the risk of early heart attack; including three that had not been previously identified.(1)

Research also shows that genes play a major role in determining how patients might react to medications that are commonly used to treat heart-related conditions.

For example, it’s been found that approximately 30 percent of the nearly 5 million patients taking Plavix do not metabolize the medication correctly because of genetic variations in their liver enzymes — putting them at about a 50 percent higher risk of heart attack or other cardiac issues, such as stroke.

People with the variant in the CYP2C19 gene (an occurrence found in about 30 percent of Caucasians and African-Americans, 20 percent of Hispanics, and up to 60 percent of Asians) had an approximate 32.4 percent reduction in effective plasma concentrations of Plavix and, as a result, were 3.6 times more likely to suffer heart attacks or other cardiac issues while taking the medication.

Studies on heart patients consistently have shown that poor metabolizers of Plavix might as well be taking a sugar pill than the standard Plavix dose, because their risk of heart attack and stroke is much higher than that of other Plavix users. However, most users don't know they are at risk, because they haven't been tested for the presence of the genetic variants causing decreased metabolism of Plavix.(2)

Genetic testing and reporting makes it easy for patients to discover any predispositions for diseases, including heart disease, and prescription medicine responses.

For more information:,

1. Source: 2009 Study by the Myocardial Infarction Genetics Consortium,
2. Rubin, Rita, “Genetic testing may yield personalized health treatments” USA TODAY, a division of Gannett Co., Inc. Feb. 24, 2010.

Related Content

FDA Clears Abbott's High Sensitivity Troponin-I Blood Test
Technology | Blood Testing | October 09, 2019
Abbott recently announced that its Architect Stat High Sensitivity Troponin-I blood test has received clearance from...
Rapid Diagnosis Protocol for Chest Pain Does Not Improve Outcomes
News | Blood Testing | September 18, 2019
Discharge of patients with suspected acute coronary syndromes under a 0- and 1-hour high-sensitivity cardiac troponin T...
Validation Studies Confirm High Accuracy of Novel HART AI-Driven Blood Tests
News | Blood Testing | March 19, 2019
Prevencio Inc. announced data confirming the high accuracy of its artificial intelligence (AI)-driven, multiple-protein...
CoaguChek XS PT Test Strips Recalled for Inaccurately Reporting High INR
News | Blood Testing | December 28, 2018
Terrific Care LLC. / Medex Supply Dist Inc. initiated a nationwide recall on Dec. 19 of Roche CoaguChek test strips, as...
Abbott Point-of-Care Blood Test Speeds Heart Attack Diagnosis
News | Blood Testing | October 26, 2018
For someone experiencing cardiac symptoms in the emergency room, every minute matters as physicians determine whether...
New Noninvasive Blood Glucose Test as Effective as Finger Prick

Image courtesy of University of Missouri School of Medicine

News | Blood Testing | October 24, 2018
For those living with diabetes, monitoring blood glucose accurately is necessary to prevent diabetes-related...
Abbott Receives CE Mark for High Sensitive Troponin-I Test
News | Blood Testing | October 16, 2018
October 16, 2018 — Abbott announced that its High Sensitive Troponin-I...
AI-Driven Blood Test Accurately Diagnoses Peripheral Artery Disease in Diabetic Patient
News | Blood Testing | September 04, 2018
Prevencio Inc. announced new data demonstrating its HART PAD test accurately diagnoses peripheral artery disease (PAD)...
More Sensitive Blood Test Diagnoses Heart Attacks Faster
News | Blood Testing | August 06, 2018
August 6, 2018 — A new test to assess a whether or not someone is having a...
Singulex cTnl Assay Can Identify Presence, Severity of CAD in Stable, Symptomatic Outpatients
News | Blood Testing | March 26, 2018
March 26, 2018 — Measurement of cardiac troponin in stable patients with chest pain using the ultra-sensitive Singule
Overlay Init