News | Antiplatelet and Anticoagulation Therapies | August 16, 2016

Warfarin Use May Not Bring Long-Term Stability for Atrial Fibrillation

Registry study finds INR values fluctuate over 18 months, even in patients considered “stable”

warfarin, long-term stability, atrial fibrillation, DCRI study, Sean Pokorney

August 16, 2016 — Warfarin prescribed to prevent strokes in atrial fibrillation may not adequately control blood clotting over the long-term, even when patients have been historically stable on the drug, according to a study from the Duke Clinical Research Institute.

The findings, published Aug. 9 in the Journal of the American Medical Association (JAMA), are based on an 18-month study of 3,749 patients diagnosed with atrial fibrillation, an irregular heart rhythm. The condition is associated with a higher risk of blood clots and stroke, which are avoidable with anticoagulants, a group of drugs that work to thin the blood and prevent clots.

Warfarin, which has an anti-clotting mechanism that targets how the body uses vitamin K, has historically been the only available drug for stroke prevention. However, warfarin can interact negatively with many other drugs and food, and patients on warfarin require regular monitoring.

While costlier than warfarin, non-vitamin K oral anticoagulants (NOACs), which were first approved for use in the United States in 2010, mostly eliminate these drawbacks while often providing similar effectiveness with improved safety.

“For these reasons, the majority of patients who are newly-diagnosed with atrial fibrillation are prescribed NOACs,” said Sean Pokorney, M.D., the study’s first author and an electrophysiology fellow at the Duke University School of Medicine.

“One of the challenges we face as a healthcare community is that there are patients who have been on warfarin for years, and a big question is whether they should be switched to a NOAC,” he said.

To consider this question, Pokorney and co-investigators looked at patients from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation, a database maintained by the Duke Clinical Research Institute. Patients were eligible to participate in the study if they were taking warfarin. Then, researchers focused on a measure of blood thinness called the international normalized ratio (INR).

For patients on warfarin, INR is typically measured monthly and ideally falls between 2 and 3. During the study’s first six months, 968 patients (26 percent of those taking warfarin) had 80 percent or more of their INR values fall in this range and 376 patients (10 percent of warfarin patients) had 100 percent of their INR values fall in this range.

Over an additional 12 months, these patients were monitored and considered “stable” if 80 percent or more of their INR values were between 2 and 3.

Among patients in the 80 percent group, 34 percent remained stable during the subsequent year. Among patents in the 100 percent group, 37 percent had stability over the next year.

“What these results essentially tell us is that patients’ past performance on warfarin doesn’t predict their future performance,” Pokorney said. “Just because patients have done well on warfarin in the past doesn’t mean they will continue to do well, and so it does call into question whether it is appropriate to switch them to a NOAC.”

The study also found that about a third of patients in both the 80 percent and 100 percent groups had one or more INR values that were well out of the ideal range during the subsequent year. Pokorney said this finding is important because risk of clotting and stroke increases most significantly when INR falls below 1.5 and risk of brain bleeding increases dramatically when INR rises above 4.

“It’s not appropriate for every patient to be treated with a NOAC, but this study shows that all patients eligible for a NOAC, even those who have done well on warfarin in the past, should have a shared decision-making conversation with their healthcare provider about considering a change,” Pokorney said.

In addition to Pokorney, study authors include DaJuanicia N. Simon, Laine Thomas, Bernard J. Gersh, Elaine M. Hylek, Jonathan P. Piccini and Eric D. Peterson.

Janssen Scientific Affairs provided funding for the patient registry and data analysis. The author’s disclosures are available in the study’s manuscript, which is available upon request.

Read the article “Advantages and Disadvantages of Novel Oral Anticoagulants.”

For more information:

Related Content

Videos | Antiplatelet and Anticoagulation Therapies | October 11, 2019
Ajay J. Kirtane, M.D., associate professor of medicine at Columbia University Irving Medical Center and director of the...
Videos | Antiplatelet and Anticoagulation Therapies | October 08, 2019
American Heart Association President Robert Harrington, M.D., explains the reasons for shorter duration dual-...
Three-Month DAPT Post-PCI Demonstrates Low Adverse Event Rate in High-Bleeding Risk Patients
News | Antiplatelet and Anticoagulation Therapies | September 30, 2019
Data from the EVOLVE Short DAPT study found that shortened three-month dual antiplatelet therapy (DAPT) did not...
Brilinta Monotherapy Reduces Clinically Relevant Bleeding Risk Post-PCI in High-Risk Patients
News | Antiplatelet and Anticoagulation Therapies | September 26, 2019
New data from the Phase IV independent TWILIGHT trial showed Brilinta (ticagrelor) monotherapy reduced the risk of BARC...
Aspirin Should Not Be Recommended for Healthy People Over 70
News | Antiplatelet and Anticoagulation Therapies | September 20, 2019
Low-dose aspirin does not prolong disability-free survival of healthy people over 70, even in those at the highest risk...
Ticagrelor Plus Aspirin Reduces Ischemic Events in Stable Coronary Patients With Diabetes
News | Antiplatelet and Anticoagulation Therapies | September 10, 2019
The combination of ticagrelor and aspirin reduces ischemic events compared with aspirin alone in patients with stable...
Prasugrel Cuts Ischemic Events in Acute Coronary Syndrome Patients
News | Antiplatelet and Anticoagulation Therapies | September 09, 2019
Prasugrel is superior to ticagrelor for reducing ischemic events in patients with acute coronary syndrome and a planned...
Advances in Anticoagulants Expand Options for VTE Prevention, Treatment
News | Antiplatelet and Anticoagulation Therapies | July 26, 2019
A new article published in AACN Advanced Critical Care outlines the traditional anticoagulant therapies familiar to...
Overlay Init