Feature | ACC | December 20, 2022 | By Melinda Taschetta-Millane

ACC 2023 Late-breaking Clinical Trials Announced

Late-breaking clinical trials for the American College of Cardiology’s Annual Scientific Session Together with World Congress of Cardiology (ACC.23/WCC) have been announced.

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Late-breaking clinical trials for the American College of Cardiology’s Annual Scientific Session Together with World Congress of Cardiology (ACC.23/WCC) have been announced. ACC.23/WCC will take place March 4-6, 2023, at the Ernets N. Morial Convention Center in New Orleans.

Top experts will debate and discuss the outcomes of leading-edge trials at ACC.23/WCC and explain how it all fits into current cardiology practice. There are five late-breaking clinical trial sessions, three featured clinical research sessions, and two late-breaking clinical trials (LBCT) deep dive sessions to help cardiologists stay up-to-date on the newest clinical research.

Search the sessions at virtual ACC.23meeting at https://accscientificsession.acc.org/en/Plan-Your-Program/Late-Breakers


Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials

Saturday, March 4, 9:30 – 10:30 a.m. ET

Bempedoic Acid And Cardiovascular Outcomes In Statin Intolerant Patients At High Cardiovascular Risk

TRILUMINATE Pivotal: A Landmark Randomized Clinical Trial Of Transcatheter Tricuspid Valve Edge-to-Edge Repair For Tricuspid Regurgitation

Statins To Prevent The Cardiotoxicity From Anthracyclines: The STOP-CA Trial


ACC Featured Clinical Research I

Saturday, March 4, noon – 1:15 p.m. ET

Results From A Phase 2, Double-blind, Placebo-controlled Trial Evaluating The Efficacy And Safety Of Baxdrostat In Patients With Uncontrolled Hypertension

Effect Of Myocardial Viability, Percutaneous Coronary Intervention And Functional Recovery On Clinical Outcomes In The REVIVED-BCIS2 Randomized Trial

Ischemia And Viability Imaging In Heart Failure: The Alternative Imaging Modalities In Ischemic Heart Failure Trial

Effect Of Evolocumab On Coronary Plaque Characteristics In Stable Coronary Artery Disease: A Multimodality Imaging Study (the Yellow III Study)

On-site Computed Tomography-derived Fractional Flow Reserve To Guide The Management Of Patients With Stable Coronary Artery Disease: The TARGET Randomized Trial


Joint American College of Cardiology/Journal of the American Medical Association Late-Breaking Clinical Trials

Sunday, March 5, 8 – 9:15 a.m. ET

Minimally Invasive Versus Conventional Sternotomy For Mitral Valve Repair Surgery: An Expertise Based Multicentre Randomised Controlled Trial (UK Mini Mitral)

Intravascular Imaging-guided Versus Angiography-guided Procedural Optimization In Complex Percutaneous Coronary Intervention

Transcatheter Edge-to-edge Repair Of Functional Mitral Regurgitation In Heart Failure: Final Five-year Results From The COAPT Trial

Transcatheter Versus Surgical Aortic Valve Replacement In Aortic Stenosis Patients At Low Surgical Risk: 3-year Outcomes From The Evolut Low Risk Trial

Complete Revascularization Strategies In Patients Presenting With Acute Coronary Syndromes And Multivessel Coronary Disease


Late-Breaking Clinical Trials III

Sunday, March 5, 9:45 – 11 a.m. ET

Randomized Controlled Trial Of Influenza Vaccine In Patients With Heart Failure To Reduce Adverse Vascular Events

The Effect Of Omecamtiv Mecarbil On Exercise Tolerance In Patients With Chronic Heart Failure And Reduced Ejection Fraction: METEORIC-HF

A Cluster-Randomized PRagmatic Trial Aimed At ImprOving Use Of Guideline Directed Medical Therapy In OutPatienTs With Heart Failure: PROMPT-HF

Patiromer For The Management Of Hyperkalemia In Subjects Receiving Renin-angiotensin-aldosterone System Inhibitor Medications For Heart Failure With Reduced Ejection Fraction: Results From The DIAMOND Trial

Updated Cumulative Results Of Treatment With Mavacamten From The EXPLORER-LTE Cohort Of The MAVA-LTE Study In Patients With Obstructive Hypertrophic Cardiomyopathy


Featured Clinical Research II

Sunday, March 5, 12:15 – 1:30 p.m. ET

Atrial Pacing For Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial

Association Of A Low-carbohydrate High-fat (Ketogenic) Diet With Plasma Lipid Levels And Cardiovascular Risk In A Population-based Cohort

Pharmaco-invasive Reperfusion Strategy With Half-dose Tenecteplase In Older St-elevation Myocardial Infarction Patients

Comparison Of 3-month Versus 12-month Dual Antiplatelet Therapy After Coronary Intervention Using The Contemporary Drug-eluting Stents With Ultrathin Struts And Advanced Polymer Technology: The Host-idea Randomized Clinical Trial

Safety And Efficacy Of Transcatheter Edge-to-Edge Mitral Repair In Degenerative Mitral Regurgitation: An Analysis Of The STS/ACC TVT Registry


Late-Breaking Clinical Trials Deep Dive I

Sunday, March 5, 2 – 3:15 p.m. ET

Late-Breaking Clinical Trials Deep Dive I


Clinical and Investigative Horizons

Sunday, March 5, 2 – 3:15 p.m. ET

Prediction Of Preeclampsia Using High-Sensitivity Troponin I

Outcomes In High-risk Pulmonary Embolism Patients Undergoing FlowTriever Mechanical Thrombectomy: Results From The FLAME Study

Health 360x Registry: Equitable Access To Point Of Care Decentralized Clinical Trials

Cardiovascular Disease And Mortality In Black Women Carrying The Amyloidogenic Val122ile Variant

Impact Of Remote Cardiac Device Monitoring On Green House Emissions: Data From The Global Cardiovascular Carbon Footprint (GCCF) Project


Joint American College of Cardiology/Journal of the American Medical Association Late-Breaking Clinical Trials

Monday, March 6, 8:30 – 9:45 a.m. ET

Pulsed Field Ablation Treatment In Paroxysmal And Persistent Atrial Fibrillation Patients: Acute And Long-term Outcomes From The Pulsed Af Pivotal Trial

Impact Of Heart Failure Management Using Thoracic Fluid Monitoring From A Novel Wearable Sensor: Results Of The Benefits Of Microcor (μCor™) In Ambulatory Decompensated Heart Failure (BMAD) Trial

A Novel Breakthrough In Wrist-Worn Transdermal Troponin-I-Sensor Assessment For Acute Myocardial Infarction

Efficacy And Safety Of Macitentan Tadalafil Fixed Dose Combination In Pulmonary Arterial Hypertension: Results From The Randomized Controlled Phase III A DUE Study

Coordinating Cardiology Clinics Randomized Trial Of Interventions To Improve Outcomes (COORDINATE) - Diabetes: Primary Results


Late-Breaking Clinical Trials V

Monday, March 6, 11 a.m. – 12:15 a.m. ET

Vigorous Exercise In Individuals With Hypertrophic Cardiomyopathy (HCM): Primary Results Of The Prospective, Multinational Lifestyle And Exercise In HCM (LIVE-HCM) Study

Return-to-play For Elite Level Athletes With Sudden Cardiac Death Predisposing Genetic Heart Diseases

Anticoagulation Strategies In Non-critically Ill Hospitalized Covid-19 Patients: Principal Outcomes Of The Freedom Covid Anticoagulation Trial

The STELLAR Phase III Trial: A Study Of Sotatercept In Combination With Background Therapy For The Treatment Of Pulmonary Arterial Hypertension

Efficacy And Safety Of The Oral PCSK9 Inhibitor, MK-0616, A Macrocyclic Peptide, In The Treatment Of Hypercholesterolemia: A Phase 2b Randomized Placebo-Controlled Clinical Trial


Featured Clinical Research III 

Monday, March 6, 12:45– 2 p.m. ET

Lifelong Endurance Exercise And Its Relationship With Coronary Atherosclerosis

Residual Inflammatory Risk In Contemporary Statin Treated Patients: A Collaborative Analyses Of 31,197 Participants In The Prominent, Reduce-it, And Strength Trials

Comparison Between Targeted Low-Density Lipoprotein Cholesterol Level Based Versus High-Intensity Statin Therapy In Patients With Coronary Artery Disease

Evaluation Of The Mechanism Of Benefit For Dapagliflozin In Heart Failure With Preserved Ejection Fraction: An Invasive Hemodynamic Randomized Trial

Safety And Efficacy Of Virtual Care Team Guided Therapeutic Optimization During Hospitalization In Patients With HFrEF:the IMPLEMENT-HF Study


Late-Breaking Clinical Trials Deep Dive II

Monday, March 6, 2:30 – 3:45 p.m. ET

Late-Breaking Clinical Trials Deep Dive II


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