News | Blood Testing | August 06, 2018

More Sensitive Blood Test Diagnoses Heart Attacks Faster

A new high-sensitivity blood test for heart attacks successfully diagnosed heart attacks faster and more accurately in the emergency room than the existing test

More Sensitive Blood Test Diagnoses Heart Attacks Faster

August 6, 2018 — A new test to assess a whether or not someone is having a heart attack upon arriving in the emergency room was safe and effective, according to new research in the American Heart Association’s journal Circulation. The test ruled out heart attack in emergency room patients faster than a conventional method.

The new high-sensitivity blood test for cardiac troponin, given in a hospital emergency room, was also found to be safe and effective. When patients present to emergency rooms with heart attack symptoms, doctors assess them in part by using a cardiac troponin test to measure a protein released into the blood when the heart is damaged.

“We did not miss any heart attacks using this test in this population,” said lead author Rebecca Vigen, M.D., M.S.C.S., a cardiologist at the University of Texas Southwestern Medical Center. “The test also allowed us to determine faster that many patients who had symptoms of a heart attack were not having a heart attack than if we had relied on the traditional test.”

Recently the U.S. Food and Drug Administration (FDA) approved a high-sensitivity troponin test already used in Europe. The researchers developed a procedure for assessing the results of the new test and compared it to existing practice using a conventional troponin test, which takes three hours to complete. Study participants were 536 patients admitted to an emergency room with heart attack symptoms, including chest pains and shortness of breath.

The new procedure successfully “ruled out” 30 percent of patients immediately and an additional 25 percent at one hour. By three hours, the new procedure ruled out heart attack in 83.8 percent of patients compared with 80.4 percent using the conventional test.

“We anticipate that this procedure will allow many patients with chest pain to be given a ‘yes’ or ‘no’ diagnosis of whether they are having a heart attack faster,” said Vigen, who hopes clinicians from other institutions will learn from these results.

Co-authors are Patricia Kuscher, M.T., A.S.C.P.; Fernabelle Fernandez, M.L.S., A.S.C.P.; Amy Yu, M.L.S., A.S.C.P.; Bryan Bertulfo, M.L.S., A.S.C.P.; Ibrahim Hashim, M.Sc; Kyle Molberg, M.D.; Deborah Diercks, M.D., M.P.H.; Jeffery Metzger, M.D., M.B.A.; Jose Soto, M.D.; Dergham Alzubaidy, M.D.; Lorie Thibodeaux, M.H.A.; Jose Joglar, M.D.; James de Lemos, M.D.; and Sandeep Das, M.D., M.P.H. Author disclosures are on the manuscript.

The National Center for Advancing Translational Sciences of the National Institutes of Health funded the study.

For more information: www.ahajournals.org/journal/circ

Reference 

Vigen R., Kutscher P., Fernandez F., et al. "Evaluation of a Novel Rule-Out Myocardial Infarction Protocol Incorporating High-Sensitivity Troponin T in a US Hospital." Circulation, Aug. 6, 2018. https://doi.org/10.1161/CIRCULATIONAHA.118.033861

Related Troponin Content

VIDEO: Use of High Sensitivity Troponin Testing in the Emergency Department

Singulex cTnl Assay Can Identify Presence, Severity of CAD in Stable, Symptomatic Outpatients

Related Content

Singulex cTnl Assay Can Identify Presence, Severity of CAD in Stable, Symptomatic Outpatients
News | Blood Testing | March 26, 2018
March 26, 2018 — Measurement of cardiac troponin in stable patients with chest pain using the ultra-sensitive Singule
Florida Medical Center First in State to Offer High Sensitive STAT Blood Test
News | Blood Testing | September 07, 2017
In July, The Heart Institute at Florida Medical Center became the first hospital in the state of Florida to offer the U...
Patients With Low Corus CAD Test Score Less Likely to Undergo Cardiac Referra
News | Blood Testing | May 02, 2017
CardioDx Inc. recently announced the publication of results from the multi-center, community-based PRESET Registry in...
New Blood Test Predicts Major Cardiac Events Better Than Clinical Evaluation of Other Common Risk Factors
News | Blood Testing | April 28, 2017
Prevencio Inc. announced the publication of data demonstrating that a simple new blood test is more accurate than...
New Study Pursues Universal Sample Bank for Troponin Tests
News | Blood Testing | April 13, 2017
April 13, 2017 — A study published recently in the American Association for Clinical Chemistry’s (AACC)...
PTS Diagnostics, FDA 510k clearance, extended HDL range, lipid panel test strips
News | Blood Testing | April 05, 2017
PTS Diagnostics announced that the U.S. Food and Drug Administration (FDA) has cleared an expanded top range for...
heart attack evaluation, blood test, HEART Score, ER, emergency room, Circulation Cardiovascular Quality and Outcomes study
News | Blood Testing | March 01, 2017
Up to 40 percent of emergency room (ER) patients with chest pain can safely go home in a little under 2 hours, using a...
troponin blood test, heart disease risk, heart attack, British Heart Foundation, BHF
News | Blood Testing | January 04, 2017
A high-sensitivity blood test could be used to predict which patients are at risk of a heart attack according to new...
Alere, INRatio PT/INR Monitor, voluntary recall, FDA
News | Blood Testing | July 12, 2016
July 12, 2016 — Following a collaborative process with the U.S. Food and Drug Administration (FDA), Alere Inc.
Overlay Init