News | October 03, 2013

New MRI Technique Can Detect Genetic Condition That Attacks Heart, Brain, Nerves

MRI systems fabry disease MRI alberta canada

October 3, 2013 — Fabry disease can be detected using a new magnetic resonance imaging (MRI) technique that was developed at the University of Alberta. The discovery of this new diagnostic tool has resulted in updated clinical guidelines for the diagnosis and treatment of Fabry disease in Canada.

Faculty of Medicine and Dentistry researchers Gavin Oudit, M.D. and Richard Thompson, Ph.D., worked with faculty colleagues Kelvin Chow and Alicia Chan on the discovery, as well as Aneal Khan from the University of Calgary. The findings were recently published in the peer-reviewed journal Circulation: Cardiovascular Imaging and involved 31 Alberta patients who have the disease.

Thompson and trainee Chow developed the MRI technique known as T1 mapping which can detect heart damage and changes in earlier stages than regular MRI scans or ultrasound. When this type of MRI is used on patients with Fabry disease, the scans can detect both the disease and the severity of damage to the heart. The T1 mapping method can be easily programmed onto MRIs around the world.

"This test can uniquely identify Fabry disease by detecting microscopic changes in the heart muscle structure that are not visible on regular images," says Thompson, who works in the Department of Biomedical Engineering. "Fabry disease can look like other diseases if you only look at the whole heart structure or function, but this T1 mapping test, that can detect the tiniest changes in the heart, could identify all the patients with Fabry disease."

"It is very likely that this technique will become a key part in clinical examination of patients with Fabry disease. This finding will advance the clinical care of these patients around the world. The implications will be widespread,” said Oudit. "Heart disease is the number one cause of death for patients with Fabry disease. The earlier the disease can be pinpointed, the sooner treatment can start. The treatment for the disease halts the condition and prevents serious damage to the heart."

Fabry disease affects 1 in 1,500 to 3,000 people but was originally thought to be a rare disease. Some countries now screen newborns for the condition that costs $200,000 a year to treat through monthly infusions called enzyme replacement therapy.

It is estimated that about 1,000 Albertans are living with the disease but not everyone who has the condition has been diagnosed. Sometimes people will see scores of kidney and heart specialists for years before anyone diagnoses the condition. Men can have a blood test to identify the condition while women, who may also carry the disease without showing symptoms, need to undergo genetic testing. The T1 mapping test can both pinpoint the disease and assess damage to the heart.”

 

Related Content

Cardiac MR, also called cardiac MRI or heart MRI, can offer data above and beyond anatomical imaging.

Cardiac MR can offer data above and beyond anatomical imaging, which is the main reason why this system was installed at Baylor Scott White Heart Hospital in Dallas. The system is a dedicated heart MRI scanner.

Feature | Magnetic Resonance Imaging (MRI) | February 19, 2020 | Dave Fornell, Editor
Videos | Magnetic Resonance Imaging (MRI) | December 20, 2019
James Carr, M.D., chair of the Department of Radiology, Northwestern University, and incoming 2020 President of the...
Greater Left Ventricular Mass Increases Risk of Heart Failure
News | Magnetic Resonance Imaging (MRI) | October 21, 2019
Elevated left ventricular mass, known as left-ventricular hypertrophy, is a stronger predictor of coronary artery...
Heart MRI example. An example of a cardiac MRI exam showing perfusion defects in the heart muscle, amount of infarct and edema and a score for myocardial salvage which can help determine if revasularization will help restore heart function.

A example of a cardiac MRI exam showing perfusion defects in the heart muscle, amount of infarct and edema and a score for myocardial salvage, which can help determine if revasularization will restore heart function following a heart attack.

News | Magnetic Resonance Imaging (MRI) | October 07, 2019
October 7, 2019 – A recent study published in the New England Journal of Medicine supports the use of
Machine Learning Could Offer Faster, More Precise Cardiac MRI Scan Results
News | Magnetic Resonance Imaging (MRI) | September 25, 2019
Cardiac magnetic resonance imaging (MRI) analysis can be performed significantly faster with similar precision to...
Haojie Wang, M.D., director of advanced cardiovascular MRI and a member of the heart valve clinic at Baylor Scott White Heart Hospital, Dallas. His hospital installed a dedicated cardiac Siemens 1.5T MRI scanner in 2018 because MRI offers soft tissue visualization not available on CT or ultrasound.

Haojie Wang, M.D., director of advanced cardiovascular MRI and a member of the heart valve clinic at Baylor Scott White Heart Hospital, Dallas. His hospital installed a dedicated cardiac Siemens 1.5T MRI scanner in 2018 because MRI offers soft tissue visualization not available on CT or ultrasound.

Feature | Magnetic Resonance Imaging (MRI) | September 06, 2019 | Jeff Zagoudis, Associate Editor
Traditionally, computed tomography (CT) and ultrasound have been the workhorse imaging modalities in the world of car
Displacement comparison at the end-systolic frame and final frame

Displacement comparison at the end-systolic frame and final frame. The three patients (V6, V10, V16) with different left-ventricle walls are shown. Point-to-surface distance is a measure to estimate the distance of a point from the reference surface. Image courtesy of WMG, University of Warwick

News | Magnetic Resonance Imaging (MRI) | August 28, 2019
A new 3-D magnetic resonance imaging (MRI) computing technique developed by scientists in WMG at the University of...
FDA Issues Draft Guidance on Medical Device Safety in MRI Environment
News | Magnetic Resonance Imaging (MRI) | August 01, 2019 | Jeff Zagoudis, Associate Editor
The U.S. Food and Drug Administration (FDA) issued a new draft guidance titled Testing and Labeling Medical Devices for...
360 Photos | Magnetic Resonance Imaging (MRI) | May 17, 2019
This is a dedicated cardiac Siemens 1.5T MRI system installed at the...