News | Cardio-oncology | May 03, 2017

Strain Imaging Improves Cardiac Surveillance of Certain Breast Cancer Patients

ACC study finds echocardiographic strain may improve management for HER2 breast cancer patients on non-anthracycline trastuzumab-based regimens

Strain Imaging Improves Cardiac Surveillance of Certain Breast Cancer Patients

May 3, 2017 — Epsilon Imaging Inc. announced a research study using EchoInsight was presented at the American College of Cardiology (ACC) 2017 Annual Scientific Session and Expo conference from a team at Northwestern University. 

The study, "Strain Imaging in Breast Cancer Patients treated with Current Non-Anthracycline, Trastuzumab-Based Regimens," was presented by Grier, EA, Akhter N, et al. Until now, trastuzumab is known to increase the risk of cardiotoxicity when combined with anthracycline agents. This study assessed the independent effects of trastuzumab in current non-anthracycline-based regimens on left ventricular function using echocardiographic strain imaging.

Thirty-four patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who were treated with non-anthracycline trastuzumab-based regimens at a single center underwent standard echo studies prior to starting chemotherapy, and again at three-month intervals during therapy. Two-dimensional speckle-tracking strain was retrospectively obtained using EchoInsight software. The results of the study showed 10 patients developing cardiotoxicity during therapy. A significant reduction in global longitudinal strain (GLS) preceded the decrease in LVEF. A significant decrease in global circumferential strain (GCS) was demonstrated after a change in GLS.

"Our study demonstrated that trastuzumab-based regimens demonstrate a risk of cardiotoxicity that is independent of anthracyclines," said Nausheen Akhter, M.D., assistant professor of medicine at Northwestern University and director of cardio oncology at Northwestern Medicine. "Close cardiac surveillance with current non-anthracycline trastuzumab-based regimens is still needed in cardio-oncology management."

For more information:

Related Content

Drug Stops Dangerous Bleeding in Patients Taking Factor Xa Inhibitors


News | ACC | March 22, 2018
March 22, 2018 — The experimental drug...
Videos | ACC | March 21, 2018
DAIC Editor Dave Fornell takes a tour of some of the most interesting new technologies on the expo floor at
ACC 2018 Late-Breaking Trials Announced
News | ACC | March 21, 2018
Here is a list of the American College of Cardiology (ACC) 2018 annual meeting late-breaking clinical trials presente
Inhaled Therapy Ineffective in Difficult-to-Treat Heart Failure at ACC 2018.

Image from presentation, "Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF: The INDIE-HFpEF Trial," Borlaug

News | ACC | March 20, 2018
March 20, 2018 — Four weeks of treatment with a novel inhaled medication failed to improve exercise capacity, daily a
Trial for Gout Drug Meets Primary Endpoint, Raises Safety Concerns, image shows a CT scan showing gout in the knees.
News | ACC | March 20, 2018
March 20, 2018 — Febuxostat, a gout dr...
More Deaths, Strokes Seen with Perioperative Beta Blocker One Year After Surgery

Image from presentation, "1-Year outcomes of perioperative beta-blockade in patients undergoing noncardiac surgery," Devereaux 

News | ACC | March 20, 2018
March 20, 2018 — During the 12 months after undergoing noncardiac surgery, patients with or at risk for heart disease
Canakinumab Doesn’t Prevent Prediabetes from Progressing to Diabetes according to a late-breaking study at ACC 2018.
News | ACC | March 20, 2018
March 20, 2018 — The anti-inflammatory...
Dabigatran Reduces Major Cardiovascular Complications in Patients With Myocardial Injury after Noncardiac Surgery
News | ACC | March 20, 2018
March 20, 2018 — Treatment with the blood-thinning drug dabigatran significantly reduced the risk of death, heart att
Statins May Bring Benefits at Time of Treatment for Heart Attack, Angina

Image from presentation, "Statins Evaluation in Coronary Procedures and Revascularization," Berwanger 

News | ACC | March 20, 2018
March 20, 2018 — Getting a large dose of a statin did not have an impact on major adverse cardiac events among a broa
Ticagrelor Has Comparable Safety to Clopidogrel after Heart Attack

Image from presentation, "Ticagrelor Versus Clopidogrel After Thrombolytic Therapy in Patients With St-Elevation Myocardial Infarction: A Randomized Clinical Trial," Berwanger 

News | ACC | March 20, 2018
March 20, 2018 — Among people younger than 75 years who were given clot busters to treat a heart attack, taking the m
Overlay Init