April 21, 2026 — Nuwellis, Inc. has announced a software update to its Aquadex SmartFlow ultrafiltration platform. The update is designed to improve usability, streamline clinical workflow, and enhance overall user experience.
A key feature of the release is a more precise ultrafiltration adjustment capability, reducing the step size to 5 mL/hr from 10 mL/hr. This advancement is particularly important in pediatric care, where small-volume fluid shifts can have a significant clinical impact.
"The Aquadex software update reflects our commitment to continuous improvement driven by customer feedback and clinical need," said Nuwellis' CEO John Erb. "This release provides clinicians with greater control over fluid management – especially in pediatric patients, which represents our largest and fastest-growing customer category – while also making the system easier to use in demanding care environments."
The update also includes enhancements aimed at improving ease-of-use of the device and therapy visibility, particularly for nursing staff managing day-to-day treatment. Key updates include:
- Refined blood flow algorithm designed to reduce nuisance alarms and improve flow stability;
- Enhanced blood flow resistance graph to provide earlier indication of potential filter clotting ; and
- Expanded hourly data log with additional therapy parameters to support clinical monitoring and documentation.
The software update is available to existing customers at no cost and can be deployed through standard update processes with support from Nuwellis' field and service teams.
For more information, visit www.nuwellis.com.
October 20, 2025 
