November 21, 2009 — A drug used to treat erectile dysfunction may improve heart function in children and young adults with single ventricle congenital heart disease, according to researchers from The Children’s Hospital of Philadelphia.
“The enhanced heart performance may improve exercise performance and quality of life in these children and young adults,” said David J. Goldberg, M.D., pediatric cardiologist at The Children’s Hospital of Philadelphia. Dr. Goldberg presented the abstract during the recent American Heart Association (AHA) Scientific Sessions in Orlando, Fla.
Researchers said heart function significantly improved in young patients who have had the Fontan operation following treatment with sildenafil (viagra). Researchers hypothesized that sildenafil may help cardiac performance by directly improving the squeeze of the heart muscle and by allowing for better filling of the heart.
In this study, researchers randomized 28 children and young adults who had undergone the Fontan operation to receive placebo or sildenafil three times a day for six weeks. After a six week break, subjects were switched to the opposite treatment course. The researchers found significant improvement in heart performance during treatment with sildenafil.
Single ventricle defects are a collection of cardiac malformations that impair the heart’s ability to pump blood. Examples include: tricuspid atresia, pulmonary atresia/intact ventricular septum and hypoplastic left heart syndrome. The Fontan operation is a procedure that redirects systemic venous blood directly to the pulmonary arteries, bypassing the heart. It is the third surgery in a staged palliation for single ventricle heart defects.
Grants from The Mark H. and Blanche M. Harrington Foundation and from Big Hearts to Little Hearts provided funding for this study.
For more information: www.chop.edu
May 02, 2024 
