Image: Johnson and Johnson
April 21, 2026 — At HRS 2026, Johnson & Johnson will launch the Cartosound Sonata Module, leveraging artificial intelligence with the Carto System to automatically transform intracardiac echocardiography (ICE) images into detailed maps, allowing physicians to build accurate models of multiple heart chambersi,ii,iii,1. The module also enables identification and automatic labeling of cardiac structuresii,iii.
Cartosound Sonata seamlessly integrates with both Soundstar Crystal (2D ICE) and Nuvision NAV (4D ICE) ultrasound cathetersiv, enabling physicians to plan and perform treatment across a range of heart rhythm conditions, including atrial fibrillation, ventricular tachycardia, and complex concomitant proceduresii,iii.
“In my experience, Cartosound Sonata elevates imaging capabilities by streamlining the process of building detailed maps of the heart across multiple chambersi using both 2D and 4D ICE technologiesiv,v, even during the most complex concomitant procedures,ii,iii” said Luigi Di Biase2, MD, PhD, FACC, FHRS, System Director Electrophysiology at Montefiore Health System, Professor of Medicine (Cardiology) Albert Einstein College of Medicine at Montefiore Hospital. “This new module continues to demonstrate the power and versatility of the Carto System and is a clear example of its continued evolution as a key platform in electrophysiology.”
2026 also marks the 30th anniversary of the Carto System. “For 30 years, the Carto System has led progress in electrophysiology, serving as the foundation of a connected platform that brings together imaging, mapping, and therapy. Looking into the future, we are decisively moving forward with continuous advancements toward new frontiers in cardiac mapping,” said Michael Bodner, Company Group Chair, Electrophysiology & Neurovascular, MedTech, Johnson & Johnson. “As we introduce Cartosound Sonata and continue to progress our PFA technologies, we remain committed to innovation that improves how arrhythmias are understood and treated, while evolving and pushing what’s possible in AFib care.”
At HRS 2026, Johnson & Johnson will present new clinical and real-world data on the Varipulse Platform for atrial fibrillation, highlighting safety, workflow efficiency, and real-world patient outcomesvi,vii,viii. Fully integrated with the Carto System, Varipulse delivers precise, efficient, and reproducible treatment outcomesix,x,xi. In the U.S., the latest VaripulsePlus update introduces automated irrigation flow control, reinforcing the platform’s safety profile and supporting procedural consistency and physician confidencexii,xiii. Building on this advancement, the company recently launched the Varipulse Pro3 platform in Europe with a new pulse sequence to streamline procedures and enhance workflow efficiencyxiv,xv.
Highlights of data being presented at HRS include:
Late-Breaking Presentation: Variable Loop Circular Catheter Pulse Field Ablation in Real-World Practice: Low Complication Rates Across Patient and Procedural Characteristics. LB -525394 -03 Dr. Christopher Porterfield4
Poster Presentation: The Variable Loop Circular Catheter Safety Survey (VariSure) Early Results. PO -02 -152. Dr. Christopher Porterfield4
Poster Presentation: Zero-exchange Workflow With a Variable Loop PFA Catheter and No Dedicated Mapping Catheter Improves Procedural Efficiency. PO -04 -270. Dr. Mark D. Metzl5
Poster Presentation: Hospital Readmission Among Patients with Paroxysmal Atrial Fibrillation Undergoing Ablation Using a Non-Integrated Pulsed Field Catheter With Carto 3 versus EnSite™ Electroanatomical Mapping System. PO -01-334. Dr. Ronnie Rong6
Poster Presentation: A Prospective Within -Patient Comparison of Transesophageal and Contemporary 4D Intracardiac Echocardiography for Left Atrial Appendage Closure (ICE4 -TEE Study). PO -01-323. Dr. Jiaqi Mi7
For more information , visit J&J MedTech electrophysiology.
1 As compared to Cartosound FAM Module
2 Dr. Di Biase is a consultant for Johnson & Johnson. Dr. Di Biase was not compensated for this authorship contribution.
3 Varipulse Pro is not currently approved in the United States
4 Dr. Porterfield served as a study investigator and as a consultant for Johnson & Johnson. Dr. Porterfield was not compensated for this authorship contribution.
5 Dr. Metzl served as a study investigator and as a consultant for Johnson & Johnson. Dr. Metzl was not compensated for this authorship contribution.
6 Dr. Rong served as a study investigator and as a consultant for Johnson & Johnson. Dr. Rong was not compensated for this authorship contribution.
7 Dr. Mi served as a study investigator and as a consultant for Johnson & Johnson. Dr. Mi was not compensated for this authorship contribution.
i Cartosound Sonata Module IFU. UG-5463-0184H, Pg.1. jnjmedtech. 2026
ii Cartosound Sonata Module IFU. UG-5463-0184H, Pg.2. jnjmedtech. 2026
iii Cartosound Sonata Module IFU. UG-5463-0184H, Pg.3. jnjmedtech. 2026
iv Cartosound Sonata Module IFU. UG-5463-0184H, Pg.4. jnjmedtech. 2026
v Cartosound Sonata Module IFU. UG-5463-0184H, Pg.8. jnjmedtech. 2026
vi Metzl MD, Wasserlauf J, Joshi N, et al. Zero-exchange workflow with a variable loop PFA catheter and no dedicated mapping catheter improves procedural efficiency. Presented at: Heart Rhythm Society (HRS) 2026; April 23–26, 2026; Chicago, IL.
vii Porterfield CP, Krishnan K, Khaykin Y, et al. Variable loop circular catheter pulsed field ablation in real-world practice: low complication rates across patient and procedural characteristics. Presented at: Heart Rhythm Society (HRS) 2026; April 24, 2026; Chicago, IL.
viii Porterfield CP, Munjal J, Hushion MJ, et al. The variable loop circular catheter real-world safety survey: VARISURE early results. Presented at: Heart Rhythm Society (HRS) 2026; April 23–26, 2026; Chicago, IL.
ix Di Biase L, Marazzato J, Gomez T, et al. Application Repetition and Electrode-Tissue-Contact Results in Deeper Lesions Using a Pulsed-Field Ablation Circular Variable Loop Catheter. Europace. Published online August 16, 2024. Page 3, paragraph 2, Results Section
x Duytschaever M, De Potter T, Grimaldi M, et al. Paroxysmal Atrial Fibrillation Ablation Using a Novel Variable-Loop Biphasic Pulsed Field Ablation Catheter Integrated With a 3-Dimensional Mapping System: 1-Year Outcomes of the Multicenter inspIRE Study. Circ Arrhythm Electrophysiol. 2023 Mar;16(3):e011780. Page 5, Column 1, paragraph 1
xi Reddy VY, Calkins H, Mansour M, et al. Pulsed field ablation to treat paroxysmal atrial fibrillation: safety and effectiveness in the admIRE pivotal trial. Circulation. Published online September 11, 2024. doi: 10.1161/CIRCULATIONAHA.124.070333.Page 5, paragraph 2, Procedural Data Section
xii Almorad A, Sebag FS, Brix Kronborg M, et al. Acute safety, effectiveness and procedural workflow for the pulsed field ablation variable loop circular catheter in AF procedures: a prospective, multicenter, post-market clinical trial. Presented at: European Society of Cardiology (ESC) Congress; September 1, 2025; Madrid, Spain.
xiii Porterfield C, Krishnan K, Saleem M, Steckman D, Ebinger M, Gampa A, et al. Real-world safety profile of a multi-electrode variable loop pulsed-field ablation catheter. Presented at: Kansas City Heart Rhythm Symposium 2025; August 16 2025; Overland Park (Kansas City), KS.
xiv Zito E, Mansour M, Reddy VY, et al. Assessment of temperature dynamics in pulsed field ablation with a variable-loop circular catheter: a comparative analysis of waveform configurations and irrigation rates in specimens of bovine ventricular myocardium. Europace. 2025;27:euaf278. doi:10.1093/europace/euaf278.
xv VARIPULSE Pulse Field Ablations in an in vitro model: temperature characterization of sequence 2 at 30 mL/min vs commercial sequence 1 at 4 mL/min and 30 mL/min. Engineering report. Report No. 502270676.
April 14, 2026 
