News | Ventricular Assist Devices (VAD) | August 07, 2015

Mayo Clinic Study Supports Left Ventricular Assist Devices for Heart Failure

Results confirm effectiveness of LVADs for patients with restrictive cardiomyopathy waiting for heart transplant

Mayo Clinic, LVAD, study, heart failure, restrictive cardiomyopathy, RCM

Thoratec HeartMate II image courtesy of Thoratec


August 7, 2015 — Mayo Clinic is announcing results of a study on the effectiveness of left ventricular assist devices (LVAD) in treating patients with a form of cardiomyopathy called restrictive cardiomyopathy (RCM). The Mayo Clinic study, which is the largest study of its kind to date, demonstrates that LVAD devices are a viable and accessible option for treating patients with RCM, who would otherwise see their health deteriorate or who may not survive. The study suggests criteria that clinicians can use for successful implementation of these devices in RCM.

Approximately 500,000 people are currently living with cardiomyopathy, which is a condition that affects the muscles in the heart. RCM is a rare form of cardiomyopathy that limits the heart muscle from relaxing between beats when the blood returns from the body back to the heart. This causes the heart to pump weakly and restricts the flow of blood to the heart’s chambers. An LVAD is a mechanical pump that helps pump blood from the heart to the rest of the body.

This study, which was conducted by Mayo Clinic specialists in the Division of Cardiovascular Diseases, the Division of Cardiovascular Surgery and the Department of Health Sciences Research, was published in the Journal of Heart and Lung Transplantation.

“As a result of Mayo Clinic research, we now know we can improve clinical outcomes for patients with end-stage restrictive cardiomyopathy by using a left-ventricular assist device, which has become a standard therapeutic device for treating heart failure in dilated and ischemic cardiomyopathy. This is promising news, because patients with RCM have few therapeutic options and we continue to face donor shortages for transplant patients” said Sudhir Kushwaha, M.D., medical director of cardiac transplantation and mechanical circulatory support at Mayo Clinic in Rochester, Minnesota.

The study was conducted using data from 28 patients with end-stage heart failure who had received a continuous-flow LVAD between January 2008 and August 2013, as a treatment bridge until a heart transplant could be conducted or who were not heart transplant candidates. Mayo Clinic cardiologists studied each patient’s preoperative data, short-term postoperative events and long-term results. The research team reported improved survival rates and fewer complications in patients who received an LVAD device, whether they had eventually received a heart transplant or not.

“While other studies have focused on risk factors associated with post-LVAD survival, this is the first study to focus exclusively on end-stage RCM patients and to identify the parameters associated with better outcomes,” said Lyle Joyce, M.D., Ph.D., heart transplant surgeon and surgical director of Mayo Clinic’s VAD program. “For example, we have defined criteria such as size of the left ventricle which is very important in determining outcome in these patients, suggesting that with careful selection we can offer these patients a much better outcome and eventual cardiac transplantation.”

For more information: www.mayoclinic.org


Related Content

News | Ventricular Assist Devices (VAD)

June 19, 2024 — When electrophysiologist Eugenio Cingolani, MD, isn’t seeing patients, he can usually be found in his ...

Home June 19, 2024
Home
News | Ventricular Assist Devices (VAD)

October 31, 2023 — Tenaya Therapeutics, Inc., a clinical-stage biotechnology company with a mission to discover, develop ...

Home October 31, 2023
Home
News | Ventricular Assist Devices (VAD)

June 7, 2023 — Magenta Medical Ltd. has announced the initiation of its FDA-approved Early Feasibility Study with the ...

Home June 07, 2023
Home
News | Ventricular Assist Devices (VAD)

March 1, 2023 — Mesoblast Limited, global leader in allogeneic cellular medicines for inflammatory diseases, today ...

Home March 01, 2023
Home
News | Ventricular Assist Devices (VAD)

November 2, 2022 — For decades, left ventricular-assist devices (LVADs) have extended the lives of people whose hearts ...

Home November 02, 2022
Home
News | Ventricular Assist Devices (VAD)

October 18, 2022 — The U.S. Food and Drug Administration (FDA) is providing updates to the FDA website to include ...

Home October 18, 2022
Home
News | Ventricular Assist Devices (VAD)

August 25, 2022 — The U.S. Food and Drug Administration (FDA) issued a statement that Medtronic, Inc. is recalling ...

Home August 25, 2022
Home
News | Ventricular Assist Devices (VAD)

August 5, 2022 — Black people and women with severe heart failure who might be good candidates for surgery to implant a ...

Home August 05, 2022
Home
News | Ventricular Assist Devices (VAD)

June 23, 2022 — Medtronic, Inc. is recalling a single lot of HeartWare HVAD System batteries due to welding defects that ...

Home June 23, 2022
Home
News | Ventricular Assist Devices (VAD)

June 8, 2022 — The U.S. Food and Drug Administration (FDA) has issued a release stating that Medtronic is recalling the ...

Home June 08, 2022
Home
Subscribe Now