News | Stroke | June 29, 2016

MRI May Predict Brain Bleeding Risk Post-Stroke Treatment

NIH scientists develop technique that provides new insight into stroke

DEFUSE-2 study, MRI, brain bleeding risk, post-stroke treatment, NIH

This image combines pre- and post-treatment scans from the same patient. Analysis of the two scans revealed that the area and size of post-treatment bleeding corresponded to blood-brain barrier disruption (shown in green, yellow and red) prior to therapy. Image courtesy of Richard Leigh, NINDS.

June 29, 2016 — In a study of stroke patients, investigators confirmed through magnetic resonance imaging (MRI) brain scans an association between the extent of disruption to the brain’s protective blood-brain barrier and the severity of bleeding following invasive stroke therapy. The results of the National Institutes of Health-funded study were published in Neurology.

These findings are part of the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE)-2 Study. The study was designed to see how MRIs can help determine which patients undergo endovascular therapy following ischemic stroke caused by a clot blocking blood flow to the brain. Endovascular treatment targets the ischemic clot itself, either removing it or breaking it up with a stent.

The blood-brain barrier is a layer of cells that protects the brain from harmful molecules passing through the bloodstream. After stroke, the barrier is disrupted, becoming permeable and losing control over what gets into the brain.

“The biggest impact of this research is that information from MRI scans routinely collected at a number of research hospitals and stroke centers can inform treating physicians on the risk of bleeding,” said Richard Leigh, M.D., a scientist at NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and an author on the study.

In this study, brain scans were collected from more than 100 patients before they underwent endovascular therapy, within 12 hours of stroke onset. Leigh and his team obtained the images from DEFUSE-2 investigators.

Using a new method of image processing, Leigh’s group was able to get detailed measurements on the extent to which the blood-brain barrier is disrupted following a stroke. Combining that data with findings from the DEFUSE-2 study revealed that large degrees of blood-brain barrier disruption were associated with severe bleeding following endovascular therapy. Extensive breakdown of the blood-brain barrier was associated with parenchymal hematoma, a form of bleeding in the brain that carries the greatest risk for the patient. In addition, the results showed a link between the location of blood-brain barrier damage and post-treatment brain bleeding.  

Ischemic stroke patients are increasingly receiving combination therapy, endovascular treatment along with an intravenous drug known as tissue plasminogen activator (t-PA), to effectively break up clots in the brain. However, bleeding into the damaged brain tissue is a serious complication of both acute stroke therapies. t-PA has been shown to be most effective when given within a few hours of stroke onset, but the treatment window for endovascular therapy is unknown.

“With the growing precision of brain imaging technology, researchers are able to get a detailed look at what is going on in the brain during a stroke. Innovative studies, such as DEFUSE-2, can help patients and their doctors make more informed decisions about medical care,” said Walter Koroshetz, M.D., director of NINDS.

According to the authors, examining blood-brain barrier disruption on brain images may potentially help doctors identify patients not likely to benefit from endovascular therapy. “It is too early to say how these images will be able to help guide clinical decisions, but they can expand how we think about stroke, especially as we try to broaden treatment options for this disease that can have devastating consequences,” said Leigh.

The DEFUSE-3 trial is currently underway, in which researchers will use imaging data to select patients for endovascular therapy up to 16 hours after stroke onset. The patients’ recovery will be closely monitored for three months following the treatment.  

This study was supported by the NIH (NS039325, NS051372, NIH Intramural Program).

For more information: www.nih.gov

Related Content

Materialise Receives FDA Clearance for Cardiovascular Planning Software Suite
Technology | Advanced Visualization | June 13, 2019
Three-dimensional (3-D) printing software and solutions company Materialise has received U.S. Food and Drug...
Technological Advancements Expected to Drive Virtual Reality Growth in Healthcare
News | Advanced Visualization | April 04, 2019
Increasing demand for innovative diagnostic techniques, neurological disorders and increasing disease awareness are...
DrChrono and 3D4Medical Partner to Bring 3-D Interactive Modeling to Physician Practices
News | Advanced Visualization | March 18, 2019
DrChrono Inc. and 3D4Medical have teamed up so practices across the United States can access 3-D interactive modeling...
Videos | Advanced Visualization | March 05, 2019
Augmented reality (AR) and virtual reality (VR) are starting to be adopted for physician training, patient education
Philips Introduces IntelliSpace Portal 11 at ECR 2019
Technology | Advanced Visualization | February 27, 2019
Philips announced the launch of IntelliSpace Portal 11, the latest release of the company’s comprehensive, advanced...
Philips and Microsoft have partnered to develop an augmented reality system to help imporve workflow and procedural navigation in the cath lab. Physicians wearing visors can view and interact with true 3-D holograms above the patient on the table and manipulate the image with voice and hand motion commands to avoid breaking the sterile field. Virtual reality in the cath lab, interventional lab, hybrid OR, or cardiovascular lab.

Philips and Microsoft have partnered to develop an augmented reality system to help imporve workflow and procedural navigation in the cath lab. Physicians wearing visors can view and interact with true 3-D holograms above the patient on the table and manipulate the image with voice and hand motion commands to avoid breaking the sterile field. 

News | Advanced Visualization | February 25, 2019
Philips will unveil a new mixed reality concept developed together with Microsoft that the company says is designed for...
Medivis Launches SurgicalAR Augmented Reality Platform
Technology | Advanced Visualization | February 14, 2019
Medical imaging and visualization company Medivis officially unveiled SurgicalAR, its augmented reality (AR) technology...
Videos | Advanced Visualization | December 12, 2018
This is an example of the FDA-cleared OpenSight augmented reality (AR) system for surgical planning from NovaRad at t
Nihon Kohden Launches Augmented Reality Electrophysiology Training App at HIMSS18
Technology | Advanced Visualization | March 06, 2018
Nihon Kohden announced the launch of the Nihon Kohden Dimensions Augmented Reality (AR) App to complement the Clinical...
NIH Issues $2.2 Million Grant for Augmented Reality Cardiac Hologram Research
News | Advanced Visualization | February 15, 2018
February 15, 2018 — The National Institutes of Health (NIH) awarded a $2.2 million research grant to healthcare techn
Overlay Init