News | September 05, 2007

New Dual Chamber Pacemakers Reduce SND Risk by 40 Percent

September 6, 2007 – The New England Journal of Medicine published the first study to demonstrate a clear superiority of newer forms of dual chamber pacing for sinus node disease versus older pacemaker technology.

The study showed that reducing pacing to the heart’s lower right chamber to less than 10 percent in patients with dual chamber pacemakers lowered the relative risk of developing persistent atrial fibrillation by 40 percent compared with conventional dual chamber pacing in a trial of more than 1,000 patients with sinus node disease (SND). SND is the most common reason for pacemaker implantation and is characterized by delayed or failed conduction between the sinus node and the atria.

The trial’s objective was to demonstrate that dramatically reducing unnecessary right ventricular pacing can reduce the development of persistent atrial fibrillation. The trial was stopped early after an interim analysis revealed that patients not using the newer forms of dual chamber pacing from Medtronic showed a 1.8 times greater risk of developing persistent atrial fibrillation than those using them. This difference was highly statistically significant.

After an average of 1.7 years in the study, 68 patients who received conventional dual chamber pacing developed persistent atrial fibrillation (12.7 percent), compared with 42 patients (7.9 percent) who received “dual chamber minimal ventricular pacing, which minimizes unnecessary pacing to the right ventricle of the heart. Mortality was similar in the two patient groups, but heart failure hospitalizations were more than 50 percent lower for the group of patients with dual chamber minimal ventricular pacing (3.2 percent vs. 7.3 percent for those who received conventional dual chamber pacing).

The trial, called SAVE PACe (The Search AV Extension and Managed Ventricular Pacing for Promoting Atrioventricular Conduction) was funded by Medtronic.

For more information: and

Related Content

FDA Warns of Premature Battery Depletion in Some Medtronic Pacemakers
News | Pacemakers | May 07, 2019 | Dave Fornell, Editor
The U.S. Food and Drug Administration (FDA) issued a safety communication to alert healthcare providers and patients...
Artificial Intelligence Can Improve Emergency X-ray Identification of Pacemakers
News | Pacemakers | March 29, 2019
A research team from Imperial College London believes a new software could speed up the diagnosis and treatment of...
Medtronic Recalls Dual Chamber Pacemakers
News | Pacemakers | February 20, 2019
Medtronic is recalling its dual chamber implantable pulse generators (IPGs) due to the possibility of a software error...
CHLA/USC Team Designs Novel Micropacemaker

Model of the human heart with microprocessor located in the pericardial sac and attached to the left ventricle. Graphic courtesy of Business Wire.

News | Pacemakers | June 29, 2018
Investigators at Children's Hospital Los Angeles (CHLA) and the University of Southern California (USC) have...
Permanent Pacing Effective for Older Patients With Syncope and Bifascicular Block
News | Pacemakers | May 24, 2018
Syncope with bifascicular block may be caused by intermittent complete heart block, but competing diagnoses may coexist...
Novel Mechanical Sensor in Medtronic Micra Transcatheter Pacing System Detects Atrial Contractions, Restores AV Synchrony
News | Pacemakers | May 24, 2018
New clinical study results demonstrate that an investigational algorithm, utilizing the accelerometer signal in the...
The Boston Scientific Essentio MRI-safe pacemaker.

The Boston Scientific Essentio MRI-safe pacemaker. It is common for pacemaker patients to need magnetic resonance imaging (MRI), which has not previously been possible because the magnetic fields could damage older devices. All pacemaker vendors now have FDA-cleared MRI compatible pacemakers. 

Feature | Pacemakers | February 13, 2018 | Dave Fornell
There have been several advancements in pacemaker technologies over the past few years.
Mexican Doctors Safely Reuse Donated Pacemakers After Sterilization

Mexican government reports conclude more than half of the population does not have access to social security or private insurance that covers a pacemaker implant, and 44 percent live in poverty. Recycling donated, explanted pacemakers offers a new option for these patients.

News | Pacemakers | November 10, 2017
Mexican doctors have safely reused donated pacemakers after sterilization, shows a study presented at the 30th Mexican...
Pacemakers and Other Cardiac Devices Can Help Solve Forensic Cases
News | Pacemakers | June 20, 2017
Pacemakers and other cardiac devices can help solve forensic cases, according to a study presented at the European...
Videos | Pacemakers | May 23, 2017
Vivek Reddy, M.D., director of cardiac arrhythmia services and professor of medicine, cardiology, Mount Sinai Hospita
Overlay Init