News | Magnetic Resonance Imaging (MRI) | August 28, 2019

New MRI Technique Spots Heart Muscle Scarring Without Kidney Damage

3D MRI computing can measure strain in the heart using image registration method without gadolinium

Displacement comparison at the end-systolic frame and final frame

Displacement comparison at the end-systolic frame and final frame. The three patients (V6, V10, V16) with different left-ventricle walls are shown. Point-to-surface distance is a measure to estimate the distance of a point from the reference surface. Image courtesy of WMG, University of Warwick

The 3DTag MRI volume and segmented LV mesh

The 3DTag MRI volume and segmented LV mesh. Image courtesy of WMG, University of Warwick

August 28, 2019 — A new 3-D magnetic resonance imaging (MRI) computing technique developed by scientists in WMG at the University of Warwick focuses on hierarchical template matching (HTM) to diagnose cardiac disease without the use of gadolinium contrast. The technique is explored in an article in the journal Scientific Reports.1

MRI has long been used to diagnose cardiomyopathy, heart attacks, irregular heartbeats and other heart disease. Traditionally when a patient goes for an MRI scan they are given a dose of gadolinium, which reacts with the magnetic field of the scanner to produce an image of the protons in the metal realigning with the field. The faster the protons realign, the brighter the image features to show where the dead muscles are in the heart and what the diagnosis is. 

The dose of gadolinium, however, can have detrimental effects to other parts of the body, particularly the risk of kidney failure. 

The hierarchical template matching technique involves:

  • A numerically stable technique of left ventricular (LV) myocardial tracking;
  • A 3-D extension of local weighted mean function to transform MRI pixels; and
  • A 3-D extension of the HTM model for myocardial tracking problems.

Use of this technique eliminates the need for gadolinium, reducing the risk of damage to other organs. 

Prof. Mark Williams from WMG at the University of Warwick said, “Using 3D MRI computing technique we can see in more depth what is happening to the heart, more precisely to each heart muscle, and diagnose any issues such as remodeling of the heart that causes heart failure. The new method avoids the risk of damaging the kidney opposite to what traditional methods do by using gadolinium.” 

Jayendra Bhalodiya, who conducted the research from WMG, University of Warwick added, “This new MRI technique also takes away stress from the patient, as during an MRI the patient must be very still in a very enclosed environment, meaning some people suffer from claustrophobia and have to stop the scan. Often when they do this they have to administer another dose of the damaging gadolinium and start again. This technique doesn’t require a dosage of anything, as it tracks the heart naturally.”

For more information: www.nature.com

Related Content

FDA Approves Bayer's Gadavist Contrast for Cardiac MRI in Adult Coronary Artery Disease Patients

Concerns Over Gadolinium MRI Contrast Toxicity

VIDEO: How Serious is MRI Gadolinium Retention in the Brain and Body?

Reference

1. Bhalodiya J.M., Palit A., Ferrante E., et al. Hierarchical Template Matching for 3D Myocardial Tracking and Cardiac Strain Estimation. Nature Scientific Reports, published online Aug. 28, 2019. https://doi.org/10.1038/s41598-019-48927-2

Related Content

A cardiac MRI of athletes who had COVID-19 is seven times more effective in detecting inflammation of the heart than symptom-based testing, according to a study led by researchers at The Ohio State University Wexner Medical Center and College of Medicine with 12 other Big Ten programs.

Cardiac Magnetic Resonance Imaging in Athletes With Clinical and Subclinical Myocarditis A-D, Athlete A with subclinical possible myocarditis was asymptomatic with normal electrocardiogram (ECG), echocardiogram, and high-sensitivity troponin findings. A, T2 mapping showing elevated T2 in basal-mid inferolateral wall in short axis view. B, late gadolinium enhancement (LGE) in the basal inferolateral wall in short axis view. C, Postcontrast steady state-free precession (SSFP) images showing contrast uptake in the basal-mid inferolateral wall in short axis view. D, LGE in the inferolateral wall in 3-chamber view. E-H, Athlete B with subclinical probable myocarditis was asymptomatic with normal ECG, normal echocardiogram, and elevated high-sensitivity troponin findings. E, T2 mapping showing elevated T2 in the anteroseptal wall in short axis view. F, LGE in the anteroseptal wall in 3-chamber view. G, T2 mapping showing elevated T2 in the anteroseptal wall in 3-chamber view. F, Postcontrast SSFP image showing pericardial effusion in short axis view. I-K, Athlete C with clinical myocarditis and chest pain, dyspnea, abnormal ECG, normal echocardiogram, and normal troponin findings. I, T2 mapping showing elevated T2 in the lateral wall short axis view. J, Postcontrast SSFP images showing contrast uptake in midlateral wall in short axis view. K, LGE in the epicardial midlateral wall in short axis view. L-N, Athlete D with clinical myocarditis, chest pain, abnormal ECG, echocardiogram, and troponin findings. L, T1 mapping showing elevated native T1 in midlateral wall in short axis view. M, T2 mapping showing elevated T2 in the midlateral wall in short axis view. N, LGE in the epicardial midlateral wall in short axis view. IR indicates inferior right view; IRP, inferior, right, posterior view; PLI, posterior, left, inferior view; SL, superior left view; SLA, superior, left, anterior view. Image courtesy of JAMA Cardiol. Published online May 27, 2021. doi:10.1001/jamacardio.2021.2065

News | Cardiac Imaging | June 15, 2021
June 15, 2021 — A...
Rensselaer algorithm can identify risk of cardiovascular disease using lung cancer scan #CT
News | Cardiac Imaging | June 14, 2021
June 14, 2021 — Heart disease and cancer are the ...
Women’s Heart Attack Research Program (HARP) shows combining OCT and cardiac MRI can detect the underlying cause of heart attack in women who did not have blocked arteries

The Women’s Heart Attack Research Program (HARP) study shows combining OCT and cardiac MRI can help detect the underlying cause of heart attacks in women who did not have blocked arteries.

News | Cardiac Imaging | November 17, 2020
November 17, 2020 — Diagnostic imaging techniques were able to find the underlying cause of heart attack in many wome
An example of a CT coronary artery calcium scoring exam showing how each vessel segment is scored to assess a patient's risk for a future heart attack. Example is from Philips Healthcare.

An example of a CT coronary artery calcium scoring exam showing how each vessel segment is scored to assess a patient's risk for a future heart attack. Example is from Philips Healthcare.

News | Cardiac Imaging | September 25, 2020
September 25, 2020 — A study out of University Hospitals (UH) found that removing the cost barrier for coronary arter
Rafael Rivero, M.D., Global Head of Medical Affairs at MSI, said: "The importance of MyoStrain cannot be understated because of the test's immense clinical value and ability to quantify intramyocardial dysfunction across 48 segments of the heart. In a six-heartbeat MRI scan, MyoStrain arms physicians with novel clinical information about a patient's heart health."
News | Cardiac Imaging | August 11, 2020
August 11, 2020 — Myocardial Solutions, Inc. and United Imaging, Inc.
The Mindways Solid phantom with volume of interest in the quality assurance phantom (red circles, left side). A participant's noncontrast-enhanced axial CT (right side) with volume of interest (yellow circles) in the trabecular bone compartment of three vertebrae for bone mineral density measurements. Image courtesy of Radiological Society of North America

The Mindways Solid phantom with volume of interest in the quality assurance phantom (red circles, left side). A participant's noncontrast-enhanced axial CT (right side) with volume of interest (yellow circles) in the trabecular bone compartment of three vertebrae for bone mineral density measurements. Image courtesy of Radiological Society of North America

News | Cardiac Imaging | July 15, 2020
July 15, 2020 — ...
Cardiac MR can offer data above and beyond anatomical imaging, which is the main reason why this system was installed at Baylor Scott White Heart Hospital in Dallas. The system is a dedicated heart MRI scanner.

Cardiac MR can offer data above and beyond anatomical imaging, which is the main reason why this system was installed at Baylor Scott White Heart Hospital in Dallas. The system is a dedicated heart MRI scanner.

News | Cardiac Imaging | June 29, 2020
June 29, 2020 — A type of smart magnetic r...