News | January 02, 2007

New Pacing Technology Proven Safe

Dual-chamber pacing coupled with Boston Scientific's AV Search Hysteresis (AVSH) programming has the potential to reduce heart failure hospitalization and all cause mortality for patients at risk for sudden cardiac death according to results of the INTRINSIC RV trial, which were published this week in the January issue of the journal Circulation.

The largest ICD study to date met its primary endpoint, showing that dual-chamber pacing in combination with AVSH programming -- a proprietary feature from Boston Scientific that proactively reduces right ventricular (RV) pacing when the heart's natural rhythm is present -- performs as well as single- chamber pacing in reducing heart failure hospitalization and all cause mortality (p

"The results of this landmark study are important because dual-chamber ICD programming can provide benefits to patients that single-chamber programming may not, such as improved heart function and enhanced arrhythmia detection," said Brian Olshansky, M.D., Professor of Medicine, Director of Cardiac Electrophysiology, University of Iowa Hospitals and a lead investigator of the trial. "Prior studies have suggested that dual-chamber devices may lead to unnecessary RV pacing, which in some patients may pose safety concerns. This study showed that these perceived safety concerns were not present in the patient arm where dual-chamber pacing with AV Search Hysteresis was used."

INTRINSIC RV (Inhibition of Unnecessary RV Pacing with AV Search Hysteresis in ICDs) is a multicenter, randomized, prospective, non- inferiority trial that enrolled 1,530 patients with a current indication for an ICD at 108 centers in the U.S., Germany, Italy and Australia. The primary endpoint was a composite of all-cause mortality and heart-failure hospitalization. Patients in the dual-chamber pacing with AVSH group experienced 33 percent fewer deaths and heart-failure hospitalizations compared to single chamber pacing (p=0.072, superiority).

Related Content

Medtronic Begins Pilot Study of Investigational Extravascular ICD System
News | Implantable Cardioverter Defibrillator (ICD) | August 09, 2018
Medtronic plc announced the start of a pilot study of its investigational Extravascular Implantable Cardioverter...
ICD Placements Not Meeting Medicare Coverage Criteria Decline After Overuse Investigation Announced
Feature | Implantable Cardioverter Defibrillator (ICD) | July 11, 2018
Placement of implantable cardioverter defibrillators (ICDs) not meeting Centers for Medicare and Medicaid Services (CMS...
New Tool Predicts Benefits and Risks of Implantable Defibrillator for Heart Failure Patients
News | Implantable Cardioverter Defibrillator (ICD) | July 02, 2018
University of Washington (UW) Medicine cardiologists have developed a tool to predict which heart-failure patients...
Real-World Data Demonstrates Success Of Smart Pass Filter on Boston Scientific S-ICD System
News | Implantable Cardioverter Defibrillator (ICD) | May 16, 2018
Boston Scientific announced results from an analysis of the LATITUDE database evaluating the successful reduction of...
Online Message Board Advice on ICDs Reflects Inaccuracies
News | Implantable Cardioverter Defibrillator (ICD) | April 13, 2018
April 13, 2018 — Medical advice about implanted cardiac defibrillators obtained via an online message board appears t
Biotronik U.S. to Distribute Aziyo ECM Envelopes
News | Implantable Cardioverter Defibrillator (ICD) | April 12, 2018
Biotronik U.S. and Aziyo announced a strategic agreement allowing Biotronik to distribute Aziyo's CanGaroo...
Boston Scientific Launches Resonate Devices With HeartLogic Heart Failure Diagnostic
Technology | Implantable Cardioverter Defibrillator (ICD) | September 27, 2017
September 27, 2017 — Boston Scientific recently launched the Resonate family of...
Abbott Secures FDA Approval for MRI Compatibility on Ellipse ICD
Technology | Implantable Cardioverter Defibrillator (ICD) | September 22, 2017
Abbott announced U.S. Food and Drug Administration (FDA) approval for magnetic resonance (MR)-conditional labeling for...
Predictive Models May Help Determine Which Patients Benefit From ICDs
News | Implantable Cardioverter Defibrillator (ICD) | July 06, 2017
Two predictive models may help cardiologists decide which patients would most benefit from an implantable cardioverter...
Videos | Implantable Cardioverter Defibrillator (ICD) | June 01, 2017
Lucas Boersma, M.D., Ph.D., FESC, St.
Overlay Init