News | July 22, 2013

T2 Biosystems Announces New Data Correlating T2HemoStat Results to Clinical Outcomes in Cardiovascular Disease at ISTH

Multiple presentations feature T2MR for rapid characterization of key hematologic factors and novel clot biology detection directly from whole blood on a single, compact instrument

July 22, 2013 — T2 Biosystems announced the presentation of data strongly correlating T2Hemostat results with patients’ clinical outcomes. In 26 patients who presented with chest pain and underwent cardiac catheterization, T2HemoStat was compared to a common platelet activity assay, where T2HemoStat accurately correlated to 100 percent of bleeding event cases while the comparator did not identify bleeding events in any patients. T2HemoStat also correlated to twice the number of thrombotic cases than the comparator. These data are complemented by additional presentations that demonstrate T2MR’s ability to identify novel clot biology, which may account for previously unexplained clot behavior while providing new clinical insights into the formation and degradation of blood clots. T2HemoStat is the company’s novel system for the rapid detection of physical changes in a blood sample, identifying novel clot biology while also measuring hemostasis characteristics such as coagulation, fibrinolysis and platelet function from finger stick size, small volumes of whole blood or plasma on a single, compact instrument.

These T2HemoStat studies were presented at the XXIV Congress of the International Society on Thrombosis and Haemostasis (ISTH), June 29-July 4, 2013, in Amsterdam, the Netherlands. The research was presented by collaborators at the University of Pennsylvania and Saint Vincent Hospital of Worcester, Mass., and by Thomas Lowery, vice president of Diagnostics R&D of T2 Bio.

“There have been many challenges to developing a clinically valuable, timely and simple method to monitor platelet function in patients who have received interventional therapies,” commented Yuka-Marie Vinagre, M.D., Ph.D., chief, Critical Care Medicine, Saint Vincent Hospital and lead author of the outcomes study utilizing T2HemoStat. “In our study presented at ISTH, we were able to demonstrate that T2HemoStat is a potential method to predict the outcomes of these interventional cardiac patients. It is very simple to use and appears to have excellent clinical correlation.”

Additional studies presented at the ISTH 2013 Congress demonstrate the capabilities of T2 Bio’s core technology, T2MR, to rapidly perform multiple hemostasis measurements on a single system, including the identification of novel clotting processes that create previously unobserved clot biology.

“These new data describe a rapid and reliable means to assess a range of hemostatic conditions directly from whole blood using a single instrument, which should enhance the ability of physicians to help make important treatment decisions in a more timely manner,” said Douglas B. Cines, M.D., professor of pathology and laboratory medicine and director of the Special Coagulation Laboratory, Perelman School of Medicine-University of Pennsylvania. “In addition, by observing clotting behavior in its more natural environment of whole blood, T2HemoStat is able to provide clinicians and researchers with valuable insight into novel aspects of clotting biology.”

“T2 Bio is committed to demonstrating the value of our T2MR technology as a means to directly detect virtually any molecular, immunodiagnostic or hemostasis target,” added John McDonough, president and CEO, T2 Biosystems. “We are extremely grateful for the work our collaborators at the University of Pennsylvania and Saint Vincent Hospital have done to advance this understanding through the studies on hemostasis measurements presented at ISTH. These new data highlight the potential clinical relevance of the T2HemoStat test, as well as the research possibilities enabled by the elucidation of novel platelet biology.”

Presentations at ISTH 

1. A clinical pilot study to compare T2MR and VerifyNow P2Y12 platelet activity measurements in cardiovascular patients by Y.M. Vinagre, R. Niroula, L. Chhabra, W. Massefski and T.J. Lowery

Poster Presentation: July 1, 2013; 17:00-18:30; Abstract: 3334

2. Contraction of whole blood clots: platelets and fibrin on the exterior compress erythrocytes into close-packed polyhedral on the interior by D.B. Cines, T. Lebedeva, C. Nagaswami, V. Hayes, W. Massefski, L. Rauova, T.J. Lowery and J.W. Wiesel

Poster Presentation: July 3, 2013; 17:00-18:30; Abstract: 3364

3. Real-time dynamic measurement of hemostasis and fibrinolysis and detection of hemostatic and prothrombotic blood disorders by T2 magnetic resonanceby D.B. Cines, T. Lebedeva, M.A. Kowalska, M. Poncz, L. Rauova, A. Cuker, J.W. Weisel, J. Whitten, L.R. Skewis, W. Massefski, V. Papkov, E.C. Thayer and T.J Lowery

Oral Presentation: July 4, 2013; 16:45-17:00; Abstract: 3055

For more information:

Related Content

Validation Studies Confirm High Accuracy of Novel HART AI-Driven Blood Tests
News | Blood Testing | March 19, 2019
Prevencio Inc. announced data confirming the high accuracy of its artificial intelligence (AI)-driven, multiple-protein...
CoaguChek XS PT Test Strips Recalled for Inaccurately Reporting High INR
News | Blood Testing | December 28, 2018
Terrific Care LLC. / Medex Supply Dist Inc. initiated a nationwide recall on Dec. 19 of Roche CoaguChek test strips, as...
Abbott Point-of-Care Blood Test Speeds Heart Attack Diagnosis
News | Blood Testing | October 26, 2018
For someone experiencing cardiac symptoms in the emergency room, every minute matters as physicians determine whether...
New Noninvasive Blood Glucose Test as Effective as Finger Prick

Image courtesy of University of Missouri School of Medicine

News | Blood Testing | October 24, 2018
For those living with diabetes, monitoring blood glucose accurately is necessary to prevent diabetes-related...
Abbott Receives CE Mark for High Sensitive Troponin-I Test
News | Blood Testing | October 16, 2018
October 16, 2018 — Abbott announced that its High Sensitive Troponin-I...
AI-Driven Blood Test Accurately Diagnoses Peripheral Artery Disease in Diabetic Patient
News | Blood Testing | September 04, 2018
Prevencio Inc. announced new data demonstrating its HART PAD test accurately diagnoses peripheral artery disease (PAD)...
More Sensitive Blood Test Diagnoses Heart Attacks Faster
News | Blood Testing | August 06, 2018
August 6, 2018 — A new test to assess a whether or not someone is having a...
Singulex cTnl Assay Can Identify Presence, Severity of CAD in Stable, Symptomatic Outpatients
News | Blood Testing | March 26, 2018
March 26, 2018 — Measurement of cardiac troponin in stable patients with chest pain using the ultra-sensitive Singule
Florida Medical Center First in State to Offer High Sensitive STAT Blood Test
News | Blood Testing | September 07, 2017
In July, The Heart Institute at Florida Medical Center became the first hospital in the state of Florida to offer the U...
Patients With Low Corus CAD Test Score Less Likely to Undergo Cardiac Referra
News | Blood Testing | May 02, 2017
CardioDx Inc. recently announced the publication of results from the multi-center, community-based PRESET Registry in...
Overlay Init