News | May 20, 2008

Treatment Within Six Weeks of AF Ablation Reduces Arrhythmias

May 21, 2008 - Antiarrhythmic drug treatment during the six weeks following atrial fibrillation (AF) ablation is well tolerated and reduces the incidence of clinically significant atrial arrhythmias and the need for cardioversion or hospitalization, according to new research released at Heart Rhythm 2008, the Heart Rhythm Society’s 29th Annual Scientific Sessions.

The 5A Study, conducted by researchers at the Hospital of the University of Pennsylvania, prospectively randomized patients with paroxysmal AF who had undergone ablation to receive antiarrhythmic drugs (AAD group) or to not receive empiric antiarrhythmic treatment (no AAD group).

“It is common for atrial arrhythmias to follow atrial fibrillation ablation early on and antiarrhythmic drugs are often prescribed during this period to reduce arrhythmia episodes, however, the benefit of this approach is unclear,” stated Jean-Francois Roux, M.D., lead author and electrophysiology fellow at the Hospital of the University of Pennsylvania in Philadelphia, PA. “Our study was designed to look at the differences in outcome between using empiric AAD treatment versus not using AAD treatment in patients with AF who had undergone ablation to determine if there are in fact benefits.”

In the AAD group, the agent was given to patients beginning the night of the procedure. In the no AAD group, only AV nodal blocking agents were prescribed. All patients wore a monitor with daily and symptomatic transmissions for four weeks after discharge and were evaluated at six weeks. Of the 110 patients enrolled, 53 were randomized to AAD and 57 to no AAD.

During the six weeks following ablation, 40 percent of patients in the no AAD group met the primary endpoint (composite of atrial arrhythmias lasting more than 24 hours, requiring hospitalization or cardioversion, or intolerance to AAD), compared to 14 percent in the AAD group. Three adverse events requiring drug termination included rash, headaches and severe fatigue.

For more information:

Related Content

Boston Scientific to Acquire Cryterion Medical Inc.
News | Ablation Systems | July 13, 2018
Boston Scientific Corp. recently announced a definitive agreement to acquire Cryterion Medical Inc., a privately-held...
Treating AFib With Ablation Reduces Mortality and Stroke
News | Ablation Systems | July 05, 2018
Using catheter-based ablation instead of medications alone reduces the risks of death and stroke in patients with the...
LuxCath Showcases OmniView Light-Guided Ablation Catheter at HRS 2018
News | Ablation Systems | May 22, 2018
LuxCath LLC showcased the next generation of its proprietary OmniView light-guided catheter ablation system at the 2018...
The Kardium Globe combined mapping and ablation catheter. The device has a distal multi-electrode array consisting of 16 ribs with 122 gold-plated electrodes. Ablation can be done with up to 24 electrodes simultaneously.  #HRS2018

The Kardium Globe combined mapping and ablation catheter. The device has a distal multi-electrode array consisting of 16 ribs with 122 gold-plated electrodes. Ablation can be done with up to 24 electrodes simultaneously. 

News | Ablation Systems | May 21, 2018
May 21, 2018 — Complete pulmonary vein isolation (PVI) was achieved in more than 99 percent of patients in a first-in
CardioFocus Announces Successful Live Case Featuring HeartLight X3 System
News | Ablation Systems | May 17, 2018
Medical device manufacturer CardioFocus Inc. announced a successful live case featuring its HeartLight X3 System during...
Imricor MRI-Guided Cardiac Ablation Study Results to Be Presented at HRS 2018
News | Ablation Systems | May 10, 2018
Results from the clinical study to evaluate Imricor’s Vision-MR Ablation Catheter for the treatment of atrial flutter...
Biosense Webster Launches Carto Vizigo Bi-Directional Guidance Sheath
Technology | Ablation Systems | May 08, 2018
Biosense Webster Inc. announced its Carto Vizigo Bi-directional Guiding Sheath is now available in the United States....
Stereotaxis and Acutus Medical Announce Strategic Collaboration
News | Ablation Systems | May 04, 2018
Stereotaxis and Acutus Medical announced a strategic collaboration to integrate the Stereotaxis Niobe Magnetic...
Medtronic Cryoballoon Shows Positive Results for Patients With Persistent Atrial Fibrillation
News | Ablation Systems | April 12, 2018
Medtronic plc announced one-year results from the CRYO4PERSISTENT AF study of ablation with the Arctic Front Advance...
Boston Scientific Acquires Securus Medical Group Inc.
News | Ablation Systems | April 04, 2018
Boston Scientific Corp. announced the acquisition of Securus Medical Group Inc., a privately-held company that has...
Overlay Init