News | May 20, 2008

Treatment Within Six Weeks of AF Ablation Reduces Arrhythmias

May 21, 2008 - Antiarrhythmic drug treatment during the six weeks following atrial fibrillation (AF) ablation is well tolerated and reduces the incidence of clinically significant atrial arrhythmias and the need for cardioversion or hospitalization, according to new research released at Heart Rhythm 2008, the Heart Rhythm Society’s 29th Annual Scientific Sessions.

The 5A Study, conducted by researchers at the Hospital of the University of Pennsylvania, prospectively randomized patients with paroxysmal AF who had undergone ablation to receive antiarrhythmic drugs (AAD group) or to not receive empiric antiarrhythmic treatment (no AAD group).

“It is common for atrial arrhythmias to follow atrial fibrillation ablation early on and antiarrhythmic drugs are often prescribed during this period to reduce arrhythmia episodes, however, the benefit of this approach is unclear,” stated Jean-Francois Roux, M.D., lead author and electrophysiology fellow at the Hospital of the University of Pennsylvania in Philadelphia, PA. “Our study was designed to look at the differences in outcome between using empiric AAD treatment versus not using AAD treatment in patients with AF who had undergone ablation to determine if there are in fact benefits.”

In the AAD group, the agent was given to patients beginning the night of the procedure. In the no AAD group, only AV nodal blocking agents were prescribed. All patients wore a monitor with daily and symptomatic transmissions for four weeks after discharge and were evaluated at six weeks. Of the 110 patients enrolled, 53 were randomized to AAD and 57 to no AAD.

During the six weeks following ablation, 40 percent of patients in the no AAD group met the primary endpoint (composite of atrial arrhythmias lasting more than 24 hours, requiring hospitalization or cardioversion, or intolerance to AAD), compared to 14 percent in the AAD group. Three adverse events requiring drug termination included rash, headaches and severe fatigue.

For more information: www.hrsonline.org

Related Content

Stereotaxis Receives Regulatory Approval of e-Contact Module in Canada
Technology | Ablation Systems| December 08, 2017
December 7, 2017 — Stereotaxis Inc.
CardioFocus Announces European CE Mark Approval of HeartLight Excalibur Balloon
Technology | Ablation Systems| October 10, 2017
October 10, 2017 — CardioFocus Inc. recently announced the European CE Mark approval of the HeartLight Excalibur Ball
The Apama Radiofrequency (RF) Balloon Catheter System.
News | Ablation Systems| October 02, 2017
October 2, 2017 — Boston Scientific announced a definitive agreement to acquire Apama Medical Inc., a privately-held
Three New Atrial Fibrillation Studies to Feature HeartLight Endoscopic Ablation System
News | Ablation Systems| August 07, 2017
CardioFocus Inc. announced that its HeartLight Endoscopic Ablation System is being featured in three new major clinical...
Medtronic Announces First Enrollments in STOP AF First Clinical Trial
News | Ablation Systems| July 24, 2017
Medtronic plc recently announced first enrollments in the STOP AF First clinical trial. The trial will evaluate the...
Biosense Webster multi-electrode RF ablation balloon

Biosense Webster's multi-electrode RF ablation balloon with irrigation. The system allows operators to change the energy levels of each electrode to avoid damaging sensitive underlying critical structures like the esophagus or phrenic nerve.

Feature | Ablation Systems| May 17, 2017 | Dave Fornell
May 17, 2017 – Clinical trial results from a first-in-human study evaluating the acute feasibility of an investigatio
Abbott Announces CE Mark for New Cardiac Ablation Catheter
News | Ablation Systems| May 10, 2017
Abbott announced CE Mark of the TactiCath Contact Force Ablation Catheter, Sensor Enabled, developed to make it easier...
Medtronic, expanded indication, Freezor Xtra Cryoablation Catheter, AVNRT, atrioventricular nodal re-entrant tachycardia
Technology | Ablation Systems| February 16, 2017
Medtronic plc announced the U.S. Food and Drug Administration (FDA) has approved its Freezor Xtra Cryoablation Catheter...
CardioFocus, HeartLight Excalibur Balloon, 22nd Annual AF Symposium, atrial fibrillation, initial clinical evaluation
News | Ablation Systems| January 25, 2017
CardioFocus Inc. recently announced the initial clinical evaluation of the HeartLight Excalibur Balloon, a next-...
catheter ablations, atrial fibrillation, stroke risk, Intermountain Medical Center Heart Institute study, AHA Scientific Sessions, American Heart Association
News | Ablation Systems| November 14, 2016
Atrial fibrillation patients with a prior history of stroke who undergo catheter ablation lower their long-term risk of...
Overlay Init