News | January 30, 2012

VAP Test Improves ID of Carotid Intima-Media Thickness Progression

January 30, 2012 — Expanded cholesterol assessment of moderate risk patients can play an important role in identifying and monitoring the progression of atherosclerosis. That’s according to a clinical study that used the Vertical Auto Profile (VAP) cholesterol test to analyze lipids potentially associated with carotid intima-media thickness (CIMT).

The study; Indicators of the Atherogenic Lipoprotein Phenotype Measured with Density Gradient Ultracentrifugation Predict Changes in Carotid Intima-Media Thickness in Men and Women was published in the January 2012 issue of Vascular Health and Risk Management. The sub-analysis demonstrated that using the VAP test density gradient ultracentrifugation (DGU) method, researchers were able to get a detailed look at how lipoproteins and their subfractions were associated with CIMT progression in men and women at moderate coronary heart disease (CHD) risk.

The study analyzed subjects from the control arm of an earlier double-blind, randomized, clinical trial designed to evaluate the effects of consumption of pomegranate juice compared to a control beverage on CIMT over a period of 18 months. Researchers investigated the relationships between baseline lipoprotein cholesterol, triglyceride (TG) and apolipoprotein B (apoB) levels assessed with the VAP Test and progression of posterior wall common CIMT in men and women at moderate risk of CHD.

Researchers reported that higher levels of TG-rich lipoprotein cholesterol, lower levels of HDL and HDL subfractions, and a greater proportion of LDL carried by more dense LDL particles were associated with CIMT progression in men and women at moderate risk for CHD. The atherogenic lipoprotein phenotype identified by the VAP Test is more strongly associated with CIMT progression than LDL, Non-HDL and apoB concentrations.

The atherogenic phenotype may have an important role in the initiation and progression of early atherosclerosis, and Maki said the data should provide clinicians with useful information to better predict CHD risk and more clearly understand the importance of measurement of lipoprotein subspecies.

The VAP Test is a direct and comprehensive measurement of cholesterol markers associated with heart disease, providing accurate information that can effectively identify and target risk in clinical care. The VAP Test identifies a significantly greater number of people at risk for heart disease than the standard cholesterol test.

For more information: www.atherotech.com

Related Content

News | Cardiovascular Clinical Studies | November 26, 2019
November 26, 2019 — The University of Connecticut (UConn) Department of Kinesiology and Hartford Healthcare have sele
FDA Issues Final Guidance on Live Case Presentations During IDE Clinical Trials
News | Cardiovascular Clinical Studies | July 10, 2019
The U.S. Food and Drug Administration (FDA) issued the final guidance “Live Case Presentations During Investigational...
Veradigm Partners With American College of Cardiology on Next-generation Research Registries
News | Cardiovascular Clinical Studies | July 03, 2019
The American College of Cardiology (ACC) has partnered with Veradigm, an Allscripts business unit, to power the next...
New FDA Proposed Rule Alters Informed Consent for Clinical Studies
News | Cardiovascular Clinical Studies | November 19, 2018
The U.S. Food and Drug Administration (FDA) is proposing to add an exception to informed consent requirements for...
A key slide from Elnabawi's presentation, showing cardiac CT plaque evaluations, showing the impact of psoriasis medication on coronary plaques at baseline and one year of treatment. It shows a reversal of vulnerable plaque development. #SCAI, #SCAI2018

A key slide from Elnabawi's presentation, showing cardiac CT plaque evaluations, showing the impact of psoriasis medication on coronary plaques at baseline and one year of treatment. It shows a reversal of vulnerable plaque development.  

Feature | Cardiovascular Clinical Studies | May 14, 2018
May 14, 2018 – New clinical evidance shows common therapy options for psoriasis (PSO), a chronic inflammatory skin di
Intravenous Drug Use is Causing Rise in Heart Valve Infections, Healthcare Costs. #SCAI, #SCAI2018
News | Cardiovascular Clinical Studies | May 14, 2018
May 14, 2018 — The opioid drug epidemic is impacting cardiology, with a new study finding the number of patients hosp
Patient Enrollment Completed in U.S. IDE Study of THERMOCOOL SMARTTOUCH SF Catheter
News | Cardiovascular Clinical Studies | March 15, 2018
March 15, 2018 –  Johnson & Johnson Medical Devices Companies announced today that Biosense Webster, Inc., who wo
Lexington Begins HeartSentry Clinical Trial
News | Cardiovascular Clinical Studies | February 20, 2018
February 20, 2018 – Lexington Biosciences, Inc., a development-stage medical device company, announced the commenceme
Endologix Completes Patient Enrollment in the ELEVATE IDE Clinical Study
News | Cardiovascular Clinical Studies | February 06, 2018
February 6, 2018 – Endologix, a developer and marketer of treatments for aortic disorders, announced the completion o
12-Month Results from Veryan Medical's MIMICS-2 IDE Study Presented at LINC
News | Cardiovascular Clinical Studies | February 01, 2018
February 1, 2018 – Thomas Zeller (Bad Krozingen, Germany) presented the 12-month results from Veryan Medical’s MIMICS
Overlay Init