Feature | December 05, 2014

Study Presented at RSNA Says Even Mild Coronary Artery Disease Puts Diabetic Patients at Risk

Researchers evaluated long-term prognostic value of CCTA in diabetic patients

December 5, 2014 — According to a new long-term study, diabetic patients with even mild coronary artery disease face the same relative risk for a heart attack or other major adverse heart events as diabetics with serious single-vessel obstructive disease. Results of the study were presented at RSNA 2014.

Researchers at the University of British Columbia and St. Paul's Hospital in Vancouver analyzed data from the Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter (CONFIRM) Registry, which was developed to examine the prognostic value of cardiac computed tomography angiography (CCTA) for predicting adverse cardiac events related to coronary artery disease. The registry, which has CCTA data on 40,000 patients from 17 centers around the world, now has five-year follow-up data on 14,000 patients.

The researchers analyzed data on 1,823 diabetic patients who underwent CCTA to detect and determine the extent of coronary artery disease, in which a waxy substance called plaque builds up inside the arteries of the heart. This plaque buildup causes the artery wall to thicken, which limits or, in some cases, completely obstructs blood flow.

Men and women (median age 61.7) in the study were categorized as having no coronary artery disease, mild disease (less than 50 percent of coronary artery narrowed), or obstructive disease (more than 50 percent artery obstruction). Over a 5.2-year follow-up period, there were 246 deaths, representing 13.5 percent of the total study group.

Major adverse cardiovascular event (MACE) data was available on 973 patients. During the follow-up period, 295 (30.3 percent) of the patients experienced a MACE, such as heart attack or a procedure to re-open an obstructed artery called a coronary revascularization.

The researchers found that both obstructive and mild, or non-obstructive, coronary artery disease as determined by CCTA were related to patient deaths and MACE. The study found that the relative risk for death or MACE for a patient with mild coronary artery disease was comparable to that of patients with single vessel obstructive disease.

"Until now, two-year follow-up studies suggested that a diabetic patient with mild or non-obstructive coronary artery disease had a lower risk of major adverse cardiovascular events and death than patients with obstructive disease," said co-author Philipp Blanke, M.D., radiologist at the University of British Columbia and St. Paul's Hospital. "Our five-year follow-up data suggests that non-obstructive and obstructive coronary artery disease as detected by cardiac CTA in diabetic patients are both associated with higher rates of mortality."

Study observers say that researchers need a better understanding of the evolution of plaque in the arteries and patient response to therapies.

Researchers say that cardiac CT angiography is helpful for identifying diabetic patients who are at higher risk for heart events, who may benefit from more aggressive therapy to help modify that risk.

Co-authors on the study include Bruce Precious, M.D., Sasi R Ganga Raju, M.B.Ch.B.m Iksung Cho, M.S., Hyuk-Jae Chang, M.D., Fay Lin, M.D., Stephan Achenbach, M.D., Daniel S. Berman, M.D., Matthew J. Budoff, M.D., Tracy Q. Callister, M.D., Mouaz Al-Mallah, M.D., Filippo Cademartiri, M.D., Ph.D., Kavitha M. Chinnaiyan, M.D., Benjamin Chow, M.D., Allison Dunning, M.S., Augustin Delago, M.D., Todd C. Villines, M.D., Martin Hadamitzky, M.D., Jorg Hausleiter, M.D., Leslee Shaw, Ph.D., Philipp A. Kaufmann, M.D., Ricardo C. Cury, M.D., Gudrun Feuchtner, M.D., Yong-Jin Kim, M.D., Erica Maffei, M.D., Gilbert Raff, M.D., Gianluca Pontone, M.D., Daniele Andreini, M.D., Hugo M. Marques, M.D., Ronen Rubinshtein, M.D., Millie Gomez, M.D. and James K. Min, M.D.

For more information: www.rsna.org

Related Content

News | Computed Tomography (CT)

June 16, 2022 — Xoran Technologies has recently received a patent for a modular computed tomography (CT) system assembly ...

Home June 16, 2022
Home
News | Computed Tomography (CT)

June 15, 2022 — Seven finalists have been selected for the Best Abstract Award in cardiovascular computed tomography ...

Home June 15, 2022
Home
News | Computed Tomography (CT)
March 29, 2022 – Cardiac computed tomography (CCT) is an accurate, noninvasive diagnostic test for obstructive coronary ...
Home March 29, 2022
Home
News | Computed Tomography (CT)
March 11, 2022 – Is cardiac computed tomography (CT) as reliable as catheterization in patients with suspected coronary ...
Home March 11, 2022
Home
News | Computed Tomography (CT)

January 31, 2022 — Lee Health’s Gulf Coast Medical Center in Fort Myers, Fla., recently became the first U.S. healthcare ...

Home January 31, 2022
Home
News | Computed Tomography (CT)

October 20, 2021 — HeartFlow Inc. announced the commencement of the REVEALPLAQUE (A pRospEctiVe, multicEnter study to ...

Home October 20, 2021
Home
News | Computed Tomography (CT)

October 14, 2021 — Cardiac computed tomography angiography (CTA) derived left atrium emptying fraction (LAEF) improves ...

Home October 14, 2021
Home
Feature | Computed Tomography (CT)

October 6, 2021 — Data presented during the late-breaking science session at the European Society of Cardiology (ESC) ...

Home October 06, 2021
Home
Feature | Computed Tomography (CT) | By Dave Fornell, DAIC Editor

The U.S. Food and Drug Administration (FDA) Sept. 30 cleared the world's first photon-counting computed tomography (CT) ...

Home October 04, 2021
Home
News | Computed Tomography (CT)

July 16, 2021 — Canon Medical Systems USA is joining forces with Cleerly in a strategic partnership to support simple ...

Home July 16, 2021
Home
Subscribe Now