News | Artificial Intelligence | December 19, 2022

Anumana and Pfizer Partner to Enable Early Detection of Underdiagnosed Cardiovascular Disease

Companies initiate research agreement supporting development of new AI-ECG algorithm to help identify patients who may be at risk of cardiac amyloidosis 

Companies initiate research agreement supporting development of new AI-ECG algorithm to help identify patients who may be at risk of cardiac amyloidosis

December 19, 2022 —  Anumana, Inc., an AI-driven health technology company and portfolio company of nference, has entered into a multi-year agreement with Pfizer, Inc. for Anumana to develop an artificial intelligence electrocardiogram algorithm (AI-ECG) designed to enable the early suspicion of cardiac amyloidosis. Anumana will conduct a clinical validation trial and pursue De Novo classification for the algorithm as a Software-as-a-Medical-Device (SaMD) and aims to gain regulatory approval for the algorithm as an SaMD for the detection of cardiac amyloidosis in the U.S., Europe and Japan. 

Cardiac amyloidosis is a serious, progressive, and underdiagnosed rare disease that leads to heart failure.1 In patients with cardiac amyloidosis, the heart walls become stiff, making it difficult for the left ventricle to properly relax and fill with blood, while at the same time hampering its ability to squeeze and pump blood out of the heart. Symptoms and comorbidities associated with cardiac amyloidosis, such as shortness of breath, knee pain, bilateral carpal tunnel syndrome, kidney disease, and gastrointestinal issues, can vary and seem unrelated, making diagnosis difficult.2,3 

“The challenge in diagnosing cardiac amyloidosis can prevent patients from getting treatment while the disease continues to progress,” said David McMullin, chief business officer of Anumana. “We believe this collaboration will demonstrate the power of Anumana’s AI-ECG algorithms to help clinicians intervene earlier, giving them greater ability to improve patient outcomes and prolong lives.” 

The research agreement with Pfizer will help deepen Anumana’s efforts to implement AI-enabled early detection software that can reveal signals from ECGs that humans cannot interpret. The ubiquitous nature of the painless, non-invasive 100-year-old ECG test gives AI-ECG algorithms the potential to reach a larger number of patients earlier. 

“AI-ECG solutions alert clinicians to humanly imperceptible patterns in ECG signals, providing an early warning for serious occult or impending disease,” said Paul Friedman, M.D., Chair of the Department of Cardiovascular Medicine at Mayo Clinic and Chair of Anumana’s Mayo Clinic Board of Advisors. “This stands to improve the lives of people with cardiac amyloidosis by improving the speed of triage and care of this group.” 

Anumana was founded in 2021 in collaboration with the Mayo Clinic Platform. Anumana has licensed Mayo Clinic AI-ECG algorithms for low ejection fraction, pulmonary hypertension, and hyperkalemia, all of which have received Breakthrough Device Designation from the U.S. FDA. These algorithms have been validated by over 75 peer-reviewed publications, including a first of its kind prospective clinical impact study on low ventricular ejection fraction that was published in Nature Medicine in 2021, and another first of its kind batch enrolled prospective clinical impact study that demonstrated the effectiveness of AI-ECG to screen for undetected atrial fibrillation in normal sinus rhythm that was published in The Lancet in 2022. 

For more information: www.anumana.ai 


Related Content

News | ECG

May 24, 2023 — Rhythm Technologies, Inc., a leading digital health care company focused on creating trusted solutions ...

Home May 24, 2023
Home
News | ECG

May 9, 2023 — Heart Test Laboratories, Inc. d/b/a HeartSciences, an artificial intelligence (AI)-based medical ...

Home May 09, 2023
Home
News | ECG

April 5, 2023 — Sharing, viewing and storing ECG data into PACS and EMR systems has been a struggle for may institutions ...

Home April 05, 2023
Home
News | ECG

March 27, 2023 — HeartBeam, Inc., a cardiac technology company that has developed the first and only 3D-vector ...

Home March 27, 2023
Home
News | ECG

March 13, 2023 — iRhythm Technologies, Inc., a leading digital health company focused on creating trusted solutions that ...

Home March 13, 2023
Home
News | ECG

December 26, 2022 — AliveCor, the global leader in FDA-cleared personal electrocardiogram (ECG) technology, today ...

Home December 26, 2022
Home
News | ECG

December 1, 2022 — Heart Test Laboratories, Inc. d/b/a HeartSciences, a medical technology company focused on saving ...

Home December 01, 2022
Home
News | ECG

October 28, 2022 — Heart Test Laboratories, Inc., a medical technology company focused on saving lives by making an ECG ...

Home October 28, 2022
Home
News | ECG

October 19, 2022 — Heart Test Laboratories, Inc. d/b/a HeartSciences, a medical technology company focused on saving ...

Home October 19, 2022
Home
News | ECG

September 29, 2022 — HeartBeam, Inc., a cardiac technology company that has developed the first and only 3D-vector ECG ...

Home September 29, 2022
Home
Subscribe Now