News | August 25, 2010

Echo Contrast Agents Not Associated With Adverse Cardiovascular Events

August 25, 2010 – Evidence suggests the use of contrast agents for echocardiography is safe and not associated with a greater incidence of myocardial infarction or mortality, according to a new study published in the American Journal of Cardiology (vol. 106, issue 5, pages 742-747, Sept. 1, 2010.)

In October 2007, the U.S. Food and Drug Administration (FDA) issued a black box warning for contrast agents used in patients undergoing echocardiography and restricted their use in patients with acute coronary syndrome, a decompensated heart and respiratory failure.

Owais A. Khawaja, M.D., department of internal medicine, Providence Hospital, Southfield, Mich., Kamran A. Shaikh, M.D., Henry Ford Health System, Detroit, and Mouaz H. Al-Mallah, M.D., Wayne State University, Detroit, performed a systemic review and meta-analysis to study the adverse effects of contrast agents used with respect to myocardial infarction and all-cause mortality. They used Medline, Embase, Biosis and Cochrane databases, searching for studies that reported myocardial infarction and all-cause mortality after the use of contrast agents for echocardiography.

Eight studies were included in the meta-analysis. A random-effect model was used and between-studies heterogeneity was estimated with I2. Eight studies reported death as an outcome and only four reported myocardial infarctions. The incidence of death in the contrast group was 0.34 percent (726 of 211,162 patients) compared to 0.9 percent (45,970 of 5.08 million patients) in the noncontrast group. The pooled odds ratio was 0.57 (95 percent confidence interval 0.32 to 1.01, p = 0.05). The reported incidence of myocardial infarction in the contrast group was 0.15 percent (86 of 57,264 patients) compared to 0.2 percent (92 of 44,503 patients) in the noncontrast group. The pooled odds ratio was 0.85 (95 percent confidence interval 0.35 to 2.05, p = 0.72). Significant heterogeneity was seen among the studies.

For more information: www.ajconline.org

Related Content

ISMRM Issues Guidelines for MRI Gadolinium Contrast Agents
News | Magnetic Resonance Imaging (MRI)| August 15, 2017
The International Society for Magnetic Resonance in Medicine (ISMRM) has provided new guidance in the use of contrast...
Oregon Tech Partners with Mindray for High-Tech Ultrasound Education
News | Ultrasound Imaging| August 04, 2017
To better prepare its ultrasound students to compete and thrive in the evolving healthcare environment, Oregon...
Carestream Shows Touch Prime Systems at Society for Vascular Ultrasound Conference
News | Cardiovascular Ultrasound| August 03, 2017
Carestream will showcase its Carestream Touch Prime and Touch Prime XE Ultrasound Systems at the Society for Vascular...
Hitachi and West Virginia University Partner to Advance Left Ventricular Mechanical Function Evaluation
News | Cardiovascular Ultrasound| July 21, 2017
Hitachi Healthcare and the West Virginia University Heart and Vascular Institute announced the formation of a new...
3-D Vascular Ultrasound Quantifies Plaque Burden to Estimate Cardiovascular Risk
News | Cardiovascular Ultrasound| July 20, 2017
July 20, 2017 — In a large, first-of-its-kind population, researchers found an experimental technique known as...
Floyd Medical Center Acquires Quartet of Toshiba Cardiac Ultrasound Systems
News | Cardiovascular Ultrasound| July 19, 2017
Floyd Medical Center in Rome, Ga., recently installed three new Aplio 500 Platinum CV ultrasound systems from Toshiba...
Cardiac CT scan showing plaque and calcification in the coronary arteries, from a Toshiba CT scanner
News | Business| July 19, 2017
July 19, 2017 — The Society of Cardiovascular Computed Tomography (SCCT) created a reimbursement fee chart for cardia
Sponsored Content | Videos | Cardiovascular Surgery| July 19, 2017
This video educational session, provided in partnership with the American Society of Echocardiography (ASE), is title
Sponsored Content | Videos | Cardiovascular Ultrasound| July 19, 2017
This video educational session, provided in partnership with the American Society of Echocardiography (ASE), is title
Guerbet Announces Plans to Streamline Contrast Media Portfolio, gadolinium MRI contrast
News | Contrast Media| July 18, 2017
Guerbet recently announced that it will phase out sales throughout the world of two products: Hexabrix (meglumine and...
Overlay Init