News | November 16, 2011

MUSTELA Trial Finds Coronary Thrombectomy Effective in Combination with Primary PCI

November 16, 2011 — Coronary thrombectomy in conjunction with percutaneous coronary intervention improved the rates of ST-segment elevation resolution when compared to a control group but did not show large differences in reduction of infarct size.

Results of the MUSTELA (A Prospective, Randomized Trial of Thrombectomy vs. no Thrombectomy in Patients with ST-Segment Elevation Myocardial Infarction and Thrombus-Rich Lesions) trial were presented at the 23rd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. TCT was sponsored by the Cardiovascular Research Foundation.

Thrombectomy is the removal of a blood clot, or thrombus. The trial’s purpose was to determine whether coronary thrombectomy as an adjunct to primary percutaneous coronary intervention (PPCI) in patients with high thrombotic burden improves myocardial perfusion and reduces infarct size. Efficacy was assessed by magnetic resonance imaging (MRI).

In this multi-center prospective trial, researchers randomized 208 consecutive patients with ST-elevation myocardial infarction (STEMI), pain-to-balloon-time <12 hours, and angiographic evidence of high thrombotic burden (thrombus grade ?3). Patients were randomized to either standard PPCI (Group A) or PPCI with thrombectomy (Group B) in a 1:1 ratio. The thrombectomy arm was divided between use of rheolytic and aspiration thrombectomy devices.

The primary endpoints were infarct size at three months (assessed with delayed-enhancement MRI) and ST-segment elevation resolution greater than 70 percent at 60 minutes after primary PCI.

ST-segment elevation resolution of greater than 70 percent occurred in 37.3 percent of the control group and 57.4 percent of the thrombectomy group.

Infarct size (IS) was reduced 19.3 percent in the control group and 20.4 percent in the thrombectomy group. A further analysis showed presence of myocardial vascular obstruction (MVO) in the control group together with less dysomogeneus scar (islands of viable myocardium inside the IS.)

Both thrombectomy systems showed to be feasible with a slight advantage for rheolytic thrombectomy.

“There were no coronary complications associated with thrombectomy,” said Anna Sonia Petronio, M.D., the lead investigator of the trial. Petronio is an associate professor and head of the cath lab in the cardiothoracic and vascular department at the University of Pisa in Italy.

For more information:

Related Content

Mandatory Public Coronary Artery Bypass Grafting Reporting Associated With Better Patient Outcomes
News | Cardiovascular Surgery | April 30, 2018
Mandatory public reporting of coronary artery bypass grafting (CABG) results in Massachusetts was associated with...
Gecko Biomedical Receives CE Mark Approval for Setalum Sealant
News | Cardiovascular Surgery | September 19, 2017
Gecko Biomedical announced it has received CE Mark approval for its Setalum Sealant, allowing the company to market its...
ClearFlow Inc. Announces Positive U.S. Clinical Trial Results
News | Cardiovascular Surgery | September 08, 2017
September 8, 2017 — ClearFlow Inc.
Videos | Cardiovascular Surgery | July 19, 2017
This video educational session, provided in partnership with the American Society of Echocardiography (ASE), is title
Intensive Glycemic Control Program Produces Significant Per-Patient Cost Savings for CABG Surgery
News | Cardiovascular Surgery | May 25, 2017
A new study from Emory University observed a near-20 percent reduction in perioperative complications, a 1.2-day...
Risk of Heart Transplant Rejection Reduced by Desensitizing Patient Antibodies
News | Cardiovascular Surgery | May 23, 2017
The risk of heart transplant rejection can be reduced by desensitizing patient antibodies, according to research...
Scientists Show How Cells React to Injury From Open-Heart Surgery
News | Cardiovascular Surgery | May 04, 2017
Cedars-Sinai Heart Institute investigators have learned how cardiac muscle cells react to a certain type of injury that...
ERACS Session Highlights Need for Standardized Best Practices in Cardiac Surgery
News | Cardiovascular Surgery | May 02, 2017
The recently formed group Enhanced Recovery After Cardiac Surgery (ERACS) hosted an organizing session in Boston on...
ClearFlow Receives Frost & Sullivan New Product Innovation Award for PleuraFlow Technology
News | Cardiovascular Surgery | May 01, 2017
ClearFlow Inc. has received the prestigious 2017 Global Frost & Sullivan Award for New Product Innovation. The...
Edwards Intuity Elite sutureless aortic valve, first implants in Connecticut, WCHN, Western Connecticut Health Network
News | Cardiovascular Surgery | February 16, 2017
Western Connecticut Health Network (WCHN) cardiothoracic surgeons Cary Passik, M.D., and Robert Gallagher, M.D., were...
Overlay Init