News | March 24, 2008

New PET-MRI Does Not Compromise Resolution, Signal

March 24, 2008 - Researchers have developed a three-dimensional scanner that combines positron emission tomography (PET) and magnetic resonance imaging (MRI), in which PET spatial resolution and signal sensitivity are not compromised and MRI images are not substantially affected.

"Both modalities preserve their functionality, even when operated isochronously," the team reports in the March 24th advance online publication of Nature Medicine.

Up until now, attempts to combine the two technologies permitted only sequential data acquisition in stand-alone systems and subsequent image fusion, limiting accuracy and reproducibility. Combining PET and MRI in one system is challenging, as regular PET detectors and photomultiplier tubes are sensitive to magnetic fields.

"We are using new avalanche photodiodes (with compact silicon light sensors), which are completely based on a semiconductor structure and show therefore no interaction with the magnetic field," Bernd J. Pichler, M.D., explained in correspondence with Reuters Health.

Using mice, Dr. Pichler, at Eberhard Karls University of Tubingen in Germany, and colleagues demonstrated the complementary information that can be obtained simultaneously, such as tumor-cell proliferation and tumor necrosis and inflammation.

"The combined PET-MRI information might make histology redundant for some applications, especially for longitudinal studies of disease progression or therapy response performed in the same subject," the authors said.

They were also able to obtain PET images simultaneously with MR spectroscopic information and functional MRI data.

"I think PET/MRI is great for studies in oncology and immunology where you want to detect cells in lymph nodes or where you need good morphological information along with your PET signal," Dr. Pichler said. "Other big applications will be cardiology, where you have the advantage of simultaneous data acquisition to avoid cardiac motion artefacts, and neurology, where you can correlate different information (eg, temporal correlation of blood flow with metabolism or receptor expression)."

He noted that his team's new design for a small animal scanner is nearly ready for commercial manufacture. "We are talking with companies," he said.

"We have already a prototype human PET-MRI in Tubingen, but this is not as mature as the animal system yet," the researcher added. "It requires many more PET detectors that need to be stabilized, and we need to have all approvals for clinical applications in place. I think within the next two to three years, we will have PET/MRI scanners clinically available."

Source: Nat Med 2008 and Reuters Health

For more information: www.nature.com

Related Content

Russian Team Developing New Technology to Significantly Reduce MRI Research Costs
News | Magnetic Resonance Imaging (MRI)| January 16, 2018
January 16, 2018 — Researchers from the NUST MISIS Engineering Center for Industrial Technologies in Russia have deve
Videos | Magnetic Resonance Imaging (MRI)| December 13, 2017
Emanuel Kanal, M.D., director of MRI services and professor of radiology and neuroradiology at the University of Pitt
GE Healthcare Launches Blanket-Like Air Technology MRI Coils
Technology | Magnetic Resonance Imaging (MRI)| December 13, 2017
GE Healthcare announced U.S. FDA 510(k) clearance of its new Air Technology, what it calls an industry-first suite of...
Toshiba Vantage Galan 3T XGO Edition MRI Features New Advanced Gradient
Technology | Magnetic Resonance Imaging (MRI)| December 11, 2017
Toshiba Medical, a Canon Group company, demonstrated the Vantage Galan 3T XGO Edition with the all-new Saturn X...
Toshiba Launches Vantage Elan Zen Edition MR for Enhanced Patient Comfort
Technology | Magnetic Resonance Imaging (MRI)| December 05, 2017
Toshiba Medical, a Canon Group company, introduced its newest magnetic resonance (MR) system, the Vantage Elan/Zen...
FDA Clears Siemens Magnetom Terra 7T MRI Device

The FDA has cleared the Siemens Magnetom Terra as the first 7T MRI system in the U.S. to gain regulatory approval.

Technology | Magnetic Resonance Imaging (MRI)| October 12, 2017
The U.S. Food and Drug Administration (FDA) cleared the first 7 Tesla (7T) magnetic resonance imaging (MRI) device,...
MR Solutions Showcases Multimodality MRI Solutions on Two Continents
News | Magnetic Resonance Imaging (MRI)| October 11, 2017
MR Solutions took their cryogen-free preclinical multimodality magnetic resonance imaging (MRI) solutions on tour in...
Toshiba Showcases MRI Workflow Enhancements at RSNA 2017
News | Magnetic Resonance Imaging (MRI)| September 21, 2017
September 21, 2017 — Toshiba Medical will highlight its latest...
GE Healthcxare Signa Pioneer MAGIC six contrasts in one scan software by SyntheticMR.

The MRI software enables several different contrasts to be obtained from one scan, shortening scan times.

Feature | Magnetic Resonance Imaging (MRI)| August 31, 2017
August 31, 2017 — The U.S. Food and Drug Administration (FDA) has granted market clearance for SyntheticMR’s SyMRI.
ISMRM Issues Guidelines for MRI Gadolinium Contrast Agents
News | Magnetic Resonance Imaging (MRI)| August 15, 2017
The International Society for Magnetic Resonance in Medicine (ISMRM) has provided new guidance in the use of contrast...
Overlay Init