News | Blood Testing | April 13, 2017

New Study Pursues Universal Sample Bank for Troponin Tests

Researchers hope to improve consistency among blood tests used to diagnose heart attacks

New Study Pursues Universal Sample Bank for Troponin Tests

April 13, 2017 — A study published recently in the American Association for Clinical Chemistry’s (AACC) Journal of Applied Laboratory Medicine describes the creation of a first-of-its-kind patient sample bank that could improve consistency among blood tests used to diagnose heart attacks and advance care for cardiac patients.

In the emergency room, a blood test for cardiac troponin — a protein released when cardiac cells are damaged — is used to identify chest pain patients who are having a heart attack so that they can be treated as quickly as possible. Specifically, a heart attack is diagnosed when a patient’s troponin concentrations exceed those found in the 99th percentile of a healthy reference population. However, the 99th percentile cutoff value varies for different troponin tests because each test manufacturer uses a different reference population. Therefore, there is a need to have samples available from one healthy reference population so that all manufacturers can use the same population to determine a universal 99th percentile cutoff for troponin. This will help to ensure that cardiac patients receive the same diagnosis and quality of care regardless of what hospital they go to and what troponin test is used.

This study examines the universal sample bank of ethnically and geographically diverse healthy subjects that AACC created to ensure that cardiac patients have consistent quality of diagnosis and care. Participants were recruited from among attendees of the 2015 AACC Annual Meeting & Clinical Lab Expo, the world’s largest conference for laboratory medicine, as well as at the University of Maryland. From those individuals who met initial eligibility criteria, 60 mL of blood was collected and tested for hemoglobin A1c, N-terminal pro–B-type natriuretic peptide and creatinine. These tests were used to exclude participants with uncontrolled diabetes, renal insufficiency, and heart disease, including most asymptomatic cardiac conditions.

In total, 808 individuals were included in the sample bank: 402 females and 406 males who are 60 percent Caucasian, 26 percent African or African American, 11 percent Asian or Pacific Islander, and 3 percent other. This sample bank and its associated data provides a unique opportunity for diagnostic manufacturers to generate a reliable 99th percentile value that applies to all troponin tests, which in turn could prevent delays in heart attack patients receiving critical treatment.

“The 99th percentiles can now be assessed by assay manufacturers and laboratories using the same patient population,” said senior paper author Robert Christenson, Ph.D., of the University of Maryland School of Medicine. “This enables establishing and applying clinical decision points in an effective and consistent manner. [Additionally,] this sample bank can and likely will be used for the determination of reference ranges for other clinical laboratory tests.”

For more information: www.aacc.org

Related Content

New Multi-Center Research Effort to Focus on Early Life Origins of Heart Health
News | Congenital Heart| June 23, 2017
Heart health in children will be the focus of three closely synergistic research projects and an integrated...
Sponsored Content | Videos | Angiography| June 22, 2017
Shimadzu Medical Systems hghlighted new features of its Trinias Interventional X-ray line at the America College of C
Pacemakers and Other Cardiac Devices Can Help Solve Forensic Cases
News | Pacemakers| June 20, 2017
Pacemakers and other cardiac devices can help solve forensic cases, according to a study presented at the European...
BioTrace Medical's Tempo Lead Shows Stability and Safety in Real-World Performance
News | Leads Implantable Devices| June 20, 2017
BioTrace Medical Inc. announced that the company’s Tempo Temporary Pacing Lead was featured in an oral presentation and...
BioImage-2 Study to Investigate Atherosclerotic Disease Progression
News | Cardiovascular Ultrasound| June 20, 2017
Mount Sinai Heart and BioImage-2 LLC recently announced the start of the BioImage-2 study investigating the progression...
Stroke2prevent Receives FDA 510(k) Clearance for A-View
Technology | Ultrasound Transesophageal echo (TEE)| June 20, 2017
June 20, 2017 — Dutch medical device company Stroke2prevent BV recently announced it has received U.S.
IABP recall for Maquet, Datascope intra-aortic balloon pump CS100 and CS300

The Datascope CS300 IABP console.

News | Hemodynamic Support Devices| June 20, 2017
June 20, 2017 — The U.S.
cardiac ultrasound echocardiography image from a GE E95 system at American society of echo to evaluate athlete's hearts and cardiac function
News | Cardiovascular Ultrasound| June 16, 2017
June 16, 2017 – Two research studies presented at the American Society of Echocardiography (ASE) 2017 scientific sess
Sponsored Content | Videos | Cardiovascular Ultrasound| June 15, 2017
Madhav Swaminathan, M.D., FASC, FAHA, clinical director of cardiothoracic anesthesiology, at Duke Univer
Overlay Init