News | November 05, 2007

Novel Agent for Echo May Be as Effective as Nuclear Perfusion

November 6, 2007 - Acusphere Inc. announced that Imagify Perfusion Stress Echo, an investigational new drug developed to assess perfusion using ultrasound (or echocardiography) for the detection of coronary heart disease, was shown to be just as good at determining whether or not a patient has disease (accuracy), according to data from two studies released today at the AHA meeting.

The results were derived from Phase 3 RAMP-1 (real time assessment of myocardial perfusion) and RAMP-2 clinical trials of Imagify (Perflubutane Polymer Microspheres for injectable suspension. Imagify is the first echocardiography imaging agent designed and shown in clinical trials to assess blood flow in the heart (perfusion). Myocardial perfusion is a sensitive marker of coronary heart disease (CHD).

Currently, perfusion information is not available using echocardiography (cardiac ultrasound), but must be obtained using a nuclear stress test. Imagify Perfusion Stress Echo would have many potential benefits over nuclear stress testing, said the manufacturer, including quicker results, lower cost and no exposure to radioactivity.

“The benefits of this important new approach for patients and physicians are very clear: ultrasound equipment is widely available, faster to use and far less expensive compared to nuclear stress testing. In addition, since there is no radiation involved, it is safer for the patient and eliminates hazardous waste disposal for the facility,” said Roxy Senior, M.D., Director of Echocardiology in the Department of Cardiology at Northwick Park Hospital and the Imperial College of Medicine, London UK, and the lead investigator in the RAMP -1 and -2 Phase 3 trials.

According to the Phase 3 data presented today at the American Heart Association’s Scientific Sessions, when compared to nuclear stress — the most frequently used imaging procedure for the assessment of coronary heart disease – Imagify Perfusion Stress Echo was shown to be:

* Just as good at determining whether or not a patient has disease (accuracy)
* Superior in ruling out disease in patients with a lower prevalence of disease (specificity)
* Superior in detecting disease in patients with a higher prevalence of disease (sensitivity)

“While the currently available echo technology can detect wall motion abnormalities one of the hallmarks of coronary artery disease, the detection of a patient’s myocardial blood flow would add a critical piece of the diagnostic puzzle when evaluating patients with heart ultrasound for their risk for heart attack. The results of the RAMP trials reported today suggest that Imagify will enable assessment of wall motion and blood flow, which when combined, is a stronger predictor of coronary artery disease than either finding alone,” said Michael Picard, M.D., Director, Clinical Echocardiography at Massachusetts General Hospital Heart Center and clinical monitor for the RAMP-2 trial.

RAMP-1 Results:

• Accuracy: 3 of 3 ultrasound blinded readers were non-inferior (p

• Sensitivity: 1 of 3 ultrasound blinded readers was non-inferior (p=0.002)

• Specificity: 2 of 3 ultrasound blinded readers were superior (p

RAMP-2 Results:

• Accuracy: 3 of 3 ultrasound blinded readers were non-inferior (p

• Sensitivity: 3 of 3 ultrasound blinded readers were superior (p

• Specificity: 1 of 3 ultrasound blinded readers was non-inferior (p=0.013)

For more information: www.acusphere.com

Related Content

Houston Methodist Hospital Enters Multi-Year Technology and Research Agreement With Siemens Healthineers
News | Cardiac Imaging| August 17, 2017
Houston Methodist Hospital and Siemens Healthineers have entered into a multi-year agreement to bring cutting-edge...
Clarius Wireless Ultrasound Scanners Now Available With Advanced Features
News | Ultrasound Imaging| August 09, 2017
Clarius Mobile Health has released advanced features and options for its wireless handheld ultrasound scanner for...
Oregon Tech Partners with Mindray for High-Tech Ultrasound Education
News | Ultrasound Imaging| August 04, 2017
To better prepare its ultrasound students to compete and thrive in the evolving healthcare environment, Oregon...
Carestream Shows Touch Prime Systems at Society for Vascular Ultrasound Conference
News | Cardiovascular Ultrasound| August 03, 2017
Carestream will showcase its Carestream Touch Prime and Touch Prime XE Ultrasound Systems at the Society for Vascular...
Hitachi and West Virginia University Partner to Advance Left Ventricular Mechanical Function Evaluation
News | Cardiovascular Ultrasound| July 21, 2017
Hitachi Healthcare and the West Virginia University Heart and Vascular Institute announced the formation of a new...
3-D Vascular Ultrasound Quantifies Plaque Burden to Estimate Cardiovascular Risk
News | Cardiovascular Ultrasound| July 20, 2017
July 20, 2017 — In a large, first-of-its-kind population, researchers found an experimental technique known as...
Floyd Medical Center Acquires Quartet of Toshiba Cardiac Ultrasound Systems
News | Cardiovascular Ultrasound| July 19, 2017
Floyd Medical Center in Rome, Ga., recently installed three new Aplio 500 Platinum CV ultrasound systems from Toshiba...
Sponsored Content | Videos | Cardiovascular Surgery| July 19, 2017
This video educational session, provided in partnership with the American Society of Echocardiography (ASE), is title
Automated medical imaging views using deep learning, artificial intelligence, Philips Epiq

GE, Siemens and Philips are among the echocardiography vendors that incorporate deep learning algorithms into its echo software to help automatically extract standard imaging views from 3-D ultrasound datasets. This is an example of the Philips Epiq system, which uses the vendor's Anatomical Intelligence software to define the anatomical structures and automatically display standard diagnostic views of the anatomy without human intervention. This can greatly speed workflow and reduce inter-operator variability. 

Feature | Artificial Intelligence| July 17, 2017 | Oksana Bandura
Medical image analysis based on artificial intelligence (AI) employ convolutional neural networks, support vector mac
Novel Approach May Improve Valve Function in Some Patients

Image courtesy of Messas, et al. JACC Basic to Translational Medicine.

News | Heart Valve Technology| June 30, 2017
June 30, 2017 — Pulsed cavitation ultrasound can be used to remotely soften human degenerative calcified biosprosthet
Overlay Init