News | Structural Heart | February 09, 2024

Smidt Heart Institute Physicians Advance Transcatheter Tricuspid Valve Replacement

Cedars-Sinai interventionalists have performed more than 100 minimally invasive tricuspid valve replacements, including the first after recent FDA approval

Physicians in the Smidt Heart Institute at Cedars-Sinai have pioneered using a catheter-based approach to treat patients with tricuspid valve disease. Image by Getty.

Physicians in the Smidt Heart Institute at Cedars-Sinai have pioneered using a catheter-based approach to treat patients with tricuspid valve disease. Image by Getty.


February 9, 2024 — Physicians in the Smidt Heart Institute at Cedars-Sinai have achieved two significant firsts: completing the institute’s 100th minimally invasive tricuspid valve replacement and performing the first-ever implantation of a new bioprosthetic tricuspid valve following its approval by the U.S. Food and Drug Administration (FDA).

The first 100 minimally invasive tricuspid procedures were done as part of the TRISCEND II clinical trial. The trial studied replacing a malfunctioning tricuspid valve with a bioprosthetic valve to treat patients with tricuspid regurgitation, a condition in which the heart’s tricuspid valve does not close tightly, causing blood to leak backward from the heart into the veins of the body.

The tricuspid valve has historically been the most challenging of the heart’s four valves to treat because of its location in the back of the heart.

Eduardo Marban

Eduardo Marbán, MD, PhD. Photo by Cedars-Sinai

 

“The Smidt Heart Institute is the only institution to have completed this many minimally invasive tricuspid valve replacement procedures, bringing extensive expertise and new options to patients impacted by tricuspid valve disease,” said Eduardo Marbán, MD, PhD, executive director of the Smidt Heart Institute and the Mark S. Siegel Family Foundation Distinguished Professor. “This impressive feat is a testament to our team’s skill in difficult-to-treat valvular conditions.”

Raj Makkar

Raj Makkar, MD. Photo by Cedars-Sinai

 

Raj Makkar, MD, associate director of the Smidt Heart Institute and vice president of Cardiovascular Innovation and Intervention for Cedars-Sinai, was the principal investigator for the TRISCEND II trial at Cedars-Sinai.

During a minimally invasive tricuspid valve replacement procedure, an interventionalist threads a thin, flexible tube called a catheter through a vein to reach the tricuspid valve. Early results of the trial led to the FDA approving the Edwards EVOQUE Tricuspid Valve Replacement System to treat eligible patients with tricuspid regurgitation.

Makkar led the Smidt Heart Institute team that performed the first EVOQUE implantation following FDA approval and has the most extensive experience globally in this groundbreaking procedure.

“We are proud and humbled to be the first in the U.S. to have implanted the world’s first commercially available transcatheter tricuspid valve,” said Makkar, the Stephen R. Corday, MD, Chair in Interventional Cardiology. “It is moments like this that further our dedication, commitment and passion to the field of interventional cardiology.”

The heart has four valves (aortic, mitral, pulmonic, and tricuspid) that open and close to move blood through the heart and to the rest of the body. If a valve cannot open or close fully it can interfere with blood flow and cause a host of health issues, including heart attack and stroke.

Moderate and severe tricuspid disease is common in the U.S. and affects an estimated 1.6 million people. Some people can manage their valvular heart disease with medications, but others need to have the damaged valve repaired or replaced.

The tricuspid valve is typically replaced during open-heart surgery. In contrast, the catheter-based approach used at Cedars-Sinai involves a tiny incision and patients typically go home the same day.

Christine Albert

Christine M. Albert, MD, MPH. Photo by Cedars-Sinai

 

"The transcatheter tricuspid valve replacement system is a game-changer for patients with tricuspid regurgitation, a condition that has traditionally been overlooked," said Christine M. Albert, MD, MPH, chair of the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai. “We are proud to be the center with the most experience in transcatheter tricuspid valve replacement, demonstrating our commitment to pioneering new treatments and expanding options for those impacted by tricuspid valve disease.”

For more information: www.cedars-sinai.org

RELATED CONTENT: 

Edwards’ EVOQUE Valve Replacement System First Transcatheter Therapy to Earn FDA Approval for Tricuspid Valve

Edwards Evoque Transcatheter Tricuspid Valve Replacement System Receives CE Mark

Edwards Announces One-year Data on Transfemoral Transcatheter Tricuspid Valve Replacement 

Six-Month Outcomes Positive for Transfemoral Tricuspid Valve in Tricuspid Regurgitation Patients 

Edwards LifeSciences Reports Positive Clinical Updates on its Transcatheter Mitral and Tricuspid Valves 

 

 


Related Content

News | Cath Lab

December 20, 2023 — Jason R. McCarthy, Ph.D., associate professor of biomedical research and translational medicine and ...

Home December 20, 2023
Home
News | Cath Lab

October 26, 2023 — Royal Philips, a global leader in health technology, announced the latest results demonstrating the ...

Home October 26, 2023
Home
News | Cath Lab

October 25, 2023 — Shockwave Medical, Inc., a pioneer in the development and commercialization of transformational ...

Home October 25, 2023
Home
News | Cath Lab

October 20, 2023 — Over the coming days, Philips will be presenting its latest solutions in cardiology and new late ...

Home October 20, 2023
Home
News | Cath Lab

October 16, 2023 — GE HealthCare (Nasdaq: GEHC) announced US FDA 510(k) clearance of Allia IGS Pulse - the latest ...

Home October 16, 2023
Home
News | Cath Lab

October 16, 2023 — Shimadzu Medical Systems USA, a subsidiary of Shimadzu Corporation, announced the first U.S ...

Home October 16, 2023
Home
News | Cath Lab

September 13, 2023 — A diagnostic test, first offered in the United States at University Hospitals (UH) Harrington Heart ...

Home September 13, 2023
Home
News | Cath Lab

August 2, 2023 — Teleflex Incorporated, a leading global provider of medical technologies, announced the U.S Food and ...

Home August 02, 2023
Home
News | Cath Lab

July 13, 2023 — Mount Sinai Queens announced the opening of a new cardiac catheterization lab that will provide rapid ...

Home July 13, 2023
Home
News | Cath Lab

June 21, 2023 — Royal Philips, a global leader in health technology, announced it has teamed up with BIOTRONIK (Lake ...

Home June 21, 2023
Home
Subscribe Now