News | April 27, 2008

Study Says Danger of Blood Substitutes is Under Reported

April 28, 2008 – A study of clinical trials involving artificial blood substitutes has shown they can cause an increased in risk of death and heart attacks, according to an article this week in the Journal of the American Medical Association.

The authors of the article analyzed data from several hemoglobin-based oxygen carrier (HBOC) trials and found a 30 percent increase in the risk of death and nearly a three-fold increase in risk of myocardial infarction when all HBOC trials were pooled. The adverse outcomes assessed were only significant in one of the trials, but the JAMA authors contend individual trials were generally not powered to detect important differences in harm and a meta-analysis of all the studies was not conducted to better understand benefits and harms for blood substitutes.

Animal evidence and early clinical trials demonstrated that HBOCs were associated with risks such as renal dysfunction and systemic vasoconstriction, the article states. However, many times these issues were underreported, the study suggested.

For more information:

Related Content

Bilateral Artery Use Does Not Improve 10-Year CABG Outcomes
News | Cardiovascular Surgery | September 06, 2018
While it is firmly established that the use of one internal thoracic artery can improve life expectancy in coronary...
Mandatory Public Coronary Artery Bypass Grafting Reporting Associated With Better Patient Outcomes
News | Cardiovascular Surgery | April 30, 2018
Mandatory public reporting of coronary artery bypass grafting (CABG) results in Massachusetts was associated with...
Gecko Biomedical Receives CE Mark Approval for Setalum Sealant
News | Cardiovascular Surgery | September 19, 2017
Gecko Biomedical announced it has received CE Mark approval for its Setalum Sealant, allowing the company to market its...
ClearFlow Inc. Announces Positive U.S. Clinical Trial Results
News | Cardiovascular Surgery | September 08, 2017
September 8, 2017 — ClearFlow Inc.
Videos | Cardiovascular Surgery | July 19, 2017
This video educational session, provided in partnership with the American Society of Echocardiography (ASE), is title
Intensive Glycemic Control Program Produces Significant Per-Patient Cost Savings for CABG Surgery
News | Cardiovascular Surgery | May 25, 2017
A new study from Emory University observed a near-20 percent reduction in perioperative complications, a 1.2-day...
Risk of Heart Transplant Rejection Reduced by Desensitizing Patient Antibodies
News | Cardiovascular Surgery | May 23, 2017
The risk of heart transplant rejection can be reduced by desensitizing patient antibodies, according to research...
Scientists Show How Cells React to Injury From Open-Heart Surgery
News | Cardiovascular Surgery | May 04, 2017
Cedars-Sinai Heart Institute investigators have learned how cardiac muscle cells react to a certain type of injury that...
ERACS Session Highlights Need for Standardized Best Practices in Cardiac Surgery
News | Cardiovascular Surgery | May 02, 2017
The recently formed group Enhanced Recovery After Cardiac Surgery (ERACS) hosted an organizing session in Boston on...
Overlay Init