News | EP Mapping and Imaging Systems | January 28, 2019

Acutus AcQMap Imaging System Helps Eliminate Arrhythmia With Single Ablation

Late-breaking UNCOVER-AF trial data reinforces safety and efficacy of non-contact cardiac mapping technology

Acutus AcQMap Imaging System Helps Eliminate Arrhythmia With Single Ablation

January 28, 2019 — Acutus Medical announced 12-month data from the UNCOVER-AF trial investigating the use of the AcQMap advanced cardiac imaging and mapping visualization system in persistent atrial fibrillation (AF) ablation procedures. Results presented at the 24th Annual AF Symposium, Jan. 24-26 in Boston, show the use of AcQMap resulted in 72.5 percent single-procedure freedom from AF at 12 months. Rigorous post-ablation monitoring showed 89.6 percent of the single-procedure patients experienced zero episodes of AF.

Atrial fibrillation is the most common supraventricular cardiac arrhythmia, affecting more than 33 million people globally.1,2 AF can lead to increased risk of stroke and heart failure, contributing to an estimated 130,000 deaths annually in the United States.3 Cardiac ablation treatment can be effective in reducing AF burden and improving quality of life for patients. However, long-term freedom from AF is achieved in as few as 50 percent of patients who undergo an ablation procedure, often making repeat procedures necessary.4

"We have mapped arrhythmias with the same technology for decades without asking if there's a better way to locate ablation targets and deliver a more precise, patient-specific therapy," said principal investigator Atul Verma, M.D., Ontario, Canada. "The results of the UNCOVER-AF trial demonstrate that with better imaging, we can perform patient-centric ablations with great success, while dramatically improving patient quality of life. This advanced cardiac imaging system paints a complete, high-definition picture in real time and is an important step in advancing the standard of care for AF ablation procedures."

UNCOVER-AF is the first trial to investigate the use of AcQMap to guide ablation therapy in a prospective study of persistent atrial fibrillation. Using AcQMap and a variety of on-market ablation technologies, investigators treated a total of 127 patients with de novo, persistent AF at 13 sites in Europe and Canada using an iterative, adaptive therapeutic approach. In 98 percent of patients, sinus rhythm was achieved at the end of the procedure. Freedom from AF after one or two procedures occurred in 93 percent of patients and 82.4 percent of patients experienced zero AF episodes in the 12 months following. Cleared by the U.S. Food and Drug Administration (FDA) in 2017, AcQMap is the only ultrasound and non-contact cardiac imaging system available for use, according to the company. The AcQMap system received CE marking in 2016.

AcQMap combines proprietary charge mapping and high-resolution ultrasound imaging to create animated, three-dimensional images in seconds that display precise anatomy and atrial arrhythmias. With AcQMap, physicians can create a full-chamber, 360-degree look at the atrium in real time for each individual patient, enabling customized treatment for every case using an iterative map, ablate, re-map, ablate strategy.

For more information:


1. Staerk L, Sherer JA, Ko D, et al. Atrial Fibrillation. Circ Res 2017;120:1501-17. DOI: 10.1161/CIRCRESAHA.117.309732.

2. Chugh, S.S., Havmoeller, R., Narayanan, K. et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circ Feb 25. 2014; 129: 837–847. DOI: 10.1161/CIRCULATIONAHA.113.005119.

3. Centers for Disease Control and Prevention. About multiple cause of death 1999–2011. CDC WONDER Online Database. 2014.

4. Mujović N, Marinković M, Lenarczyk R, Tilz R, Potpara TS. Catheter Ablation of Atrial Fibrillation: An Overview for Clinicians. Adv Ther. 2017;34(8):1897-1917. DOI: 10.1007/s12325-017-0590-z.

Related Content

CardioFocus Announces European CE Mark Approval Of HeartLight X3 System
News | Ablation Systems | April 16, 2019
CardioFocus Inc. announced the European CE Mark approval of the HeartLight X3 Endoscopic Ablation System.
First Patient Treated With QDot Micro Ablation Catheter
News | Ablation Systems | February 04, 2019
Biosense Webster has enrolled and treated the first patient in its U.S. Investigational Device Exemption (IDE) study...
FDA Approves TactiCath Contact Force Ablation Catheter, Sensor Enabled
Technology | Ablation Systems | January 21, 2019
Abbott announced U.S. Food and Drug Administration (FDA) approval of the TactiCath Contact Force Ablation Catheter,...
First Patient Treated in STELLAR Atrial Fibrillation IDE Study
News | Ablation Systems | November 30, 2018
Johnson & Johnson Medical Devices Companies announced that Biosense Webster Inc. has enrolled and treated the first...
FDA Approves Biosense Webster's Tag-Index Guided Ablation Software
Technology | Ablation Systems | October 09, 2018
Biosense Webster Inc. recently received approval from the U.S. Food and Drug Administration (FDA) for its Visitag...
Medtronic Cryoballoon Improves Quality of Life, Reduces Systems of Persistent Atrial Fibrillation
News | Ablation Systems | August 28, 2018
Medtronic plc announced new findings from the CRYO4PERSISTENT AF clinical trial demonstrating improved quality of life...
Thermedical Announces FDA IDE Approval for Clinical Study of Durablate Catheter
News | Ablation Systems | August 02, 2018
Thermedical announced that the U.S. Food and Drug Administration (FDA) has approved its Investigational Device...
Boston Scientific to Acquire Cryterion Medical Inc.
News | Ablation Systems | July 13, 2018
Boston Scientific Corp. recently announced a definitive agreement to acquire Cryterion Medical Inc., a privately-held...
Treating AFib With Ablation Reduces Mortality and Stroke
News | Ablation Systems | July 05, 2018
Using catheter-based ablation instead of medications alone reduces the risks of death and stroke in patients with the...
LuxCath Showcases OmniView Light-Guided Ablation Catheter at HRS 2018
News | Ablation Systems | May 22, 2018
LuxCath LLC showcased the next generation of its proprietary OmniView light-guided catheter ablation system at the 2018...
Overlay Init