News | October 05, 2012

Clinical Study Reveals Critical Importance of Measuring LDL-Particles for Patients with Type 2 Diabetes Mellitus

New findings published in the American Journal of Cardiology

Type 2 Diabetis Mellulitis Blood Testing Cardiac Diagnostics

October 5, 2012 — LipoScience Inc., a highly innovative diagnostic company that is advancing patient care by developing high value proprietary blood tests using nuclear magnetic resonance (NMR) technology, announced the publication of results from a clinical study in the American Journal of Cardiology (AJC) suggesting that despite having cholesterol levels considered acceptable by today’s clinical standards, patients with Type 2 diabetes mellitus (T2DM) are at increased risk for cardiovascular disease (CVD)-related events.

“Many patients with T2DM have relatively normal levels of low-density lipoprotein cholesterol (LDL-C), yet cardiovascular disease is a primary cause of death in this population,” said Hector Malave, M.D., F.A.C.C., a practicing cardiologist in Atlanta, and lead author of the AJC manuscript. “This means that physicians should consider evaluating their diabetic patients for other factors that contribute to CVD risk, including LDL particle concentration (LDL-P), as our findings suggest there is a direct association between elevated LDL particle count and increased CVD risk in our study population.”

The clinical study examined variations in lipoprotein particle concentration in patients with T2DM with very low LDL cholesterol (LDL-C) and non-HDL cholesterol levels. The 1,970 patient cases studied were selected from LipoScience’s clinical laboratory database. Selection criteria included patients with LDL cholesterol levels <70 mg/dl, non-HDL cholesterol levels <100 mg/dl, triglycerides <150 mg/dl, and HDL cholesterol >40 mg/dl.

The study found that patients with T2DM exhibited significant variation in LDL particle levels, with many having LDL-P concentrations >1,000 nmol/L, suggesting the potential for residual CVD risk.

“These findings provide further evidence that there is a subset of T2DM patients with a disproportionally higher number of LDL particles, despite having LDL-C levels that would be considered normal or low,” said Bob Honigberg, M.D., vice president, medical affairs and chief medical officer of LipoScience, and an author on the AJC manuscript. “For these patients, we know that CVD risk is linked with LDL-P, and not LDL-C, and consequently, physicians should use particle concentration to better manage patients’ residual risk.”

For more information: www.liposcience.com and www.theparticletest.com

Related Content

CoaguChek XS PT Test Strips Recalled for Inaccurately Reporting High INR
News | Blood Testing | December 28, 2018
Terrific Care LLC. / Medex Supply Dist Inc. initiated a nationwide recall on Dec. 19 of Roche CoaguChek test strips, as...
Abbott Point-of-Care Blood Test Speeds Heart Attack Diagnosis
News | Blood Testing | October 26, 2018
For someone experiencing cardiac symptoms in the emergency room, every minute matters as physicians determine whether...
New Noninvasive Blood Glucose Test as Effective as Finger Prick

Image courtesy of University of Missouri School of Medicine

News | Blood Testing | October 24, 2018
For those living with diabetes, monitoring blood glucose accurately is necessary to prevent diabetes-related...
Abbott Receives CE Mark for High Sensitive Troponin-I Test
News | Blood Testing | October 16, 2018
October 16, 2018 — Abbott announced that its High Sensitive Troponin-I...
AI-Driven Blood Test Accurately Diagnoses Peripheral Artery Disease in Diabetic Patient
News | Blood Testing | September 04, 2018
Prevencio Inc. announced new data demonstrating its HART PAD test accurately diagnoses peripheral artery disease (PAD)...
More Sensitive Blood Test Diagnoses Heart Attacks Faster
News | Blood Testing | August 06, 2018
August 6, 2018 — A new test to assess a whether or not someone is having a...
Singulex cTnl Assay Can Identify Presence, Severity of CAD in Stable, Symptomatic Outpatients
News | Blood Testing | March 26, 2018
March 26, 2018 — Measurement of cardiac troponin in stable patients with chest pain using the ultra-sensitive Singule
Florida Medical Center First in State to Offer High Sensitive STAT Blood Test
News | Blood Testing | September 07, 2017
In July, The Heart Institute at Florida Medical Center became the first hospital in the state of Florida to offer the U...
Patients With Low Corus CAD Test Score Less Likely to Undergo Cardiac Referra
News | Blood Testing | May 02, 2017
CardioDx Inc. recently announced the publication of results from the multi-center, community-based PRESET Registry in...
New Blood Test Predicts Major Cardiac Events Better Than Clinical Evaluation of Other Common Risk Factors
News | Blood Testing | April 28, 2017
Prevencio Inc. announced the publication of data demonstrating that a simple new blood test is more accurate than...
Overlay Init