News | October 05, 2012

Clinical Study Reveals Critical Importance of Measuring LDL-Particles for Patients with Type 2 Diabetes Mellitus

New findings published in the American Journal of Cardiology

Type 2 Diabetis Mellulitis Blood Testing Cardiac Diagnostics

October 5, 2012 — LipoScience Inc., a highly innovative diagnostic company that is advancing patient care by developing high value proprietary blood tests using nuclear magnetic resonance (NMR) technology, announced the publication of results from a clinical study in the American Journal of Cardiology (AJC) suggesting that despite having cholesterol levels considered acceptable by today’s clinical standards, patients with Type 2 diabetes mellitus (T2DM) are at increased risk for cardiovascular disease (CVD)-related events.

“Many patients with T2DM have relatively normal levels of low-density lipoprotein cholesterol (LDL-C), yet cardiovascular disease is a primary cause of death in this population,” said Hector Malave, M.D., F.A.C.C., a practicing cardiologist in Atlanta, and lead author of the AJC manuscript. “This means that physicians should consider evaluating their diabetic patients for other factors that contribute to CVD risk, including LDL particle concentration (LDL-P), as our findings suggest there is a direct association between elevated LDL particle count and increased CVD risk in our study population.”

The clinical study examined variations in lipoprotein particle concentration in patients with T2DM with very low LDL cholesterol (LDL-C) and non-HDL cholesterol levels. The 1,970 patient cases studied were selected from LipoScience’s clinical laboratory database. Selection criteria included patients with LDL cholesterol levels <70 mg/dl, non-HDL cholesterol levels <100 mg/dl, triglycerides <150 mg/dl, and HDL cholesterol >40 mg/dl.

The study found that patients with T2DM exhibited significant variation in LDL particle levels, with many having LDL-P concentrations >1,000 nmol/L, suggesting the potential for residual CVD risk.

“These findings provide further evidence that there is a subset of T2DM patients with a disproportionally higher number of LDL particles, despite having LDL-C levels that would be considered normal or low,” said Bob Honigberg, M.D., vice president, medical affairs and chief medical officer of LipoScience, and an author on the AJC manuscript. “For these patients, we know that CVD risk is linked with LDL-P, and not LDL-C, and consequently, physicians should use particle concentration to better manage patients’ residual risk.”

For more information: www.liposcience.com and www.theparticletest.com

Related Content

Pregnancy-Related Heart Failure Strikes Black Women Twice as Often as Other Races
News | Womens Healthcare| October 19, 2017
African American women were found to be twice as likely to be diagnosed with peripartum cardiomyopathy as compared to...
The Role of Telomere Length in Cardiovascular Risk Assessment
Feature | Cardiac Diagnostics| October 19, 2017 | Nanette H. Bishopric, M.D., FACC, FAHA
A new area of DNA testing involving telomere length may enhance a patient’s cardiovascular disease risk stratificatio
Appropriate Use Criteria Published for Valvular Heart Disease Imaging Tests
News | Clinical Decision Support| October 16, 2017
The American College of Cardiology (ACC), along with several partnering societies, recently released appropriate use...
Videos | Cardiovascular Ultrasound| October 12, 2017
Sharon Mulvagh, M.D., FRCPC, FACC, FAHA, FASE, professor, Division of Cardiology, Department of Medicine, Dalhouse Un
SunTech Medical Receives Third-Party Validation of CT40 BP Spot-Check Device
News | Blood Pressure Monitor| October 11, 2017
October 11, 2017 — The CT40 spot-check device from SunTech Medical has received third-party validation for...
New Evaluation Sends Low-Risk ER Chest Pain Patients Home Sooner
News | Cardiac Diagnostics| October 10, 2017
A new evaluation to determine whether emergency room patients with chest pain can go home and follow up with their...
Majority of High-Risk Stroke Patients Not Being Screened for Common Risk Factors
News | Stroke| September 28, 2017
September 28, 2017 — New research revealed that on average, more than 75 percent of people aged 65 and older worldwid
NIAID Scientists Illuminate Mechanism of Increased Cardiovascular Risks With HIV
News | Cardiac Diagnostics| September 14, 2017
September 14, 2017 — Scientists at the National Institutes of Health have expanded the understanding of how chronic i
Marijuana Associated With Three-Fold Risk of Death From Hypertension
News | Hypertension| September 14, 2017
Marijuana use is associated with a three-fold risk of death from hypertension, according to research published recently...
News | Cardiac Diagnostics| September 12, 2017
Contracting shingles, a reactivation of the chickenpox virus, increases a person’s risk of stroke and heart attack,...
Overlay Init