News | Cardiovascular Clinical Studies | May 20, 2024

Geisinger Enrolls First Patient in Amyloid Cardiomyopathy Trial

Cardiologist Brendan Carry, MD, and a team of Geisinger Health physicians have enrolled the first patient in the U.S. into a cardiac amyloidosis trial. The phase 3, randomized, double-blind, placebo-controlled study will evaluates the safety and effectiveness of amyloid deplete ALXN2220 in participants with transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM).

Cardiologist Brendan Carry, MD, and a team of Geisinger Medical Center physicians have enrolled the first patient in the U.S. into a cardiac amyloidosis trial. Image courtesy: Geisinger Medical Center/Mark Dastrup

Cardiologist Brendan Carry, MD, and a team of Geisinger Medical Center physicians based in Danville, PA, have enrolled the first patient in the U.S. into a cardiac amyloidosis trial. The phase 3, randomized, double-blind, placebo-controlled study will evaluates the safety and effectiveness of amyloid deplete ALXN2220 in participants with transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM). Image courtesy: Geisinger Medical Center/Mark Dastrup


May 20, 2024 — Cardiologist Brendan Carry, MD, and a team of Danville, PA-based Geisinger Medical Center physicians have enrolled the first patient in the U.S. into a cardiac amyloidosis trial. The team is also the first to in the U.S. to screen for the trial.

“If a patient qualifies for the clinical trial, it will allow us to provide a treatment option when they receive an amyloidosis diagnosis without having to travel outside of the region for care,” said Carry. “Geisinger is at the forefront of research and technological advancements that allow for better patient outcomes and improvements in their quality of life.”

Cardiac amyloidosis is caused by protein buildup between the muscle cells of the heart, increasing the thickness of the heart. As these proteins build up, the heart becomes thicker and struggles to pump blood. Over time as the heart thickens, heart failure develops.

Patients with amyloidosis can inherit it from their parents or develop the condition on their own. Signs include common heart failure symptoms, such as swelling in the extremities, increased shortness of breath and weight gain. Patients may also have neuropathy symptoms, weakness, difficulty walking, tingling or numbness in their limbs, a decrease in blood pressure when adjusting positions and carpal tunnel syndrome.

The trial is a phase 3, randomized, double-blind, placebo-controlled study that evaluates the safety and effectiveness of amyloid deplete ALXN2220 in participants with transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM).

To be considered for the trial, patients must be between the ages of 18 to 90, have a confirmed diagnosis of ATTR-CM with transthyretin that is either wild-type TTR or a variant TR genotype, and have not received prior treatment with an ATTR amyloid depleter.

This clinical trial is sponsored by Alexion Pharmaceuticals Inc.

For more information: www.geisinger.org


Related Content

News | Heart Failure

June 7, 2024 — Calcific aortic valve disease (CAVD) is the major heart valve disease that afflicts nearly 10 million ...

Home June 07, 2024
Home
News | Heart Failure

June 7, 2024 — BioCardia, Inc., a company focused on cellular and cell-derived therapeutics for the treatment of ...

Home June 07, 2024
Home
News | Heart Failure

May 28, 2024 — Yoga focused on breathing, meditation, and relaxation is linked with symptom improvement in patients with ...

Home May 28, 2024
Home
News | Heart Failure

May 22, 2024 — New research from The Cooper Institute and partners at University of Texas (UT) Southwestern Medical ...

Home May 22, 2024
Home
News | Heart Failure

April 30, 2024 — A multicenter study led by Vanderbilt University Medical Center (VUMC) and Lipscomb University College ...

Home April 30, 2024
Home
News | Heart Failure

April 16, 2024 — Each year more than 500,000 Americans undergo percutaneous coronary intervention, or PCI, a minimally ...

Home April 16, 2024
Home
News | Heart Failure

April 12, 2024 — University of Virginia School of Medicine researchers have discovered a gene on the Y chromosome that ...

Home April 12, 2024
Home
News | Heart Failure

April 2, 2024 — People who use e-cigarettes are significantly more likely to develop heart failure compared with those ...

Home April 02, 2024
Home
News | Heart Failure

March 29, 2024 — V-Wave announced it will present late-breaking data from its RELIEVE-HF pivotal trial at the American ...

Home March 29, 2024
Home
News | Heart Failure

March 25, 2024 — A team of engineers led by the University of Massachusetts Amherst and including colleagues from the ...

Home March 25, 2024
Home
Subscribe Now