News | Cardiac Imaging | August 25, 2022

Measuring Currents in the Heart at Millimeter Resolution with a Diamond Quantum Sensor

Imperfect current propagation in the heart is at the root of most cardiac diseases

August 25, 2022 — Imperfect current propagation in the heart is at the root of most cardiac diseases. Thanks to a novel magnetocardiography technique developed in the MEXT Q-LEAP Flagship project with researchers from Tokyo Tech and the University of Tokyo, we can now image these currents at millimeter-scale resolutions. Based on a diamond quantum sensor that senses the heart’s magnetic fields, the proposed system offers high resolution at room temperature, as demonstrated in experiments with rats. The technique could help deepen our understanding of several cardiac arrythmias. 

Heart problems, such as tachycardia and fibrillation, arise mainly from imperfections in the way electric currents propagate through the heart. Unfortunately, it is difficult for doctors to study these imperfections since measuring these currents involves highly invasive procedures and exposure to X-ray radiation. 

Luckily, there are other options. For instance, magnetocardiography (MCG) is a promising alternative approach to indirectly measure heart currents. The technique involves sensing minute changes in magnetic field near the heart caused by cardiac currents, which can be done in a completely contactless manner. To this end, various types of quantum sensors suitable for this purpose have been developed. However, their spatial resolution is limited to centimeter scales: not good enough to detect cardiac currents that propagate at millimeter scales. Moreover, each of these sensors has a fair share of its practical limitations, such as size and operating temperature. 

In a recent study published in Communications Physics, a team of scientists led by Associate Professor Takayuki Iwasaki of Tokyo Institute of Technology (Tokyo Tech), Japan, have now developed a novel setup to perform MCG at higher resolutions. Their approach is based on a diamond quantum sensor comprising nitrogen vacancies, which act as special magnetic “centers” that are sensitive to the weak magnetic fields produced by heart currents. 

But how does one observe the state of these centers to extract information about the cardiac currents? It turns out that the sensor is also fluorescent, which means that it easily absorbs light at specific frequencies and then re-emits them at different frequencies. Most importantly, the intensity of the light re-emitted at the nitrogen vacancies changes depending on the intensity and direction of the external magnetic field. 

The research team created an MCG setup using a 532 nm (green) laser to excite the diamond sensor and a photodiode to capture the re-emitted photons (light particles). They also developed mathematical models to accurately map these captured photons with the corresponding magnetic fields and, in turn, with the cardiac currents responsible for them. 

With an unprecedented spatial resolution of 5.1 mm, the proposed system could create detailed two-dimensional maps of the cardiac currents measured in the hearts of laboratory rats. Additionally, the diamond sensor could operate at room temperature, unlike other well-established MCG sensors that require cryogenic temperatures. This enabled the researchers to position their sensor extremely close to the heart tissue, which amplified the measured signals. “The advantages of our contactless sensor combined with our current models will allow for more precise observations of cardiac imperfections using small mammalian model animals,” highlights Dr. Iwasaki. 

Overall, the MCG setup developed in this study appears to be a promising tool for understanding many heart problems as well as other bodily processes involving electric currents. In this regard, Dr. Iwasaki remarks: “Our technique will enable the study of the origin and progression of various cardiac arrhythmias, as well as other biological current-driven phenomena.” 

Let us hope the team’s efforts will help deepen our knowledge about heart diseases, contributing to saving lives through modern medicine. 

For more information: https://www.titech.ac.jp/english/   

Reference 

DOI: https://doi.org/10.1038/s42005-022-00978-0 

 


Related Content

News | Heart Failure

January 25, 2023 — Adults living in rural areas of the United States have a 19% higher risk of developing heart failure ...

Home January 25, 2023
Home
News | Heart Failure

January 24, 2023 — Leakage of the mitral valve due to degenerative prolapse is a common condition known as primary ...

Home January 24, 2023
Home
News | Heart Failure

January 18, 2023 — Phone calls from a nurse may improve survival for patients treated for heart failure, according to a ...

Home January 18, 2023
Home
News | Heart Failure

January 16, 2023 — On any given Tuesday, you will find Brian C. Jensen, MD, cardiologist and physician-scientist ...

Home January 16, 2023
Home
News | Heart Failure

January 13, 2023 — A change to Medicare policy surrounding heart transplant may lead to increased inequities in access ...

Home January 13, 2023
Home
News | Heart Failure

January 9, 2023 — When we were little, our parents told us to take our vitamins so we could grow big and strong. Now ...

Home January 09, 2023
Home
News | Heart Failure

December 29, 2022 — Anthracyclines are a class of chemotherapies effective in treating many forms of cancer, including ...

Home December 29, 2022
Home
News | Heart Failure

December 22, 2022 — Using machine learning and clinical data from electronic health records, researchers at the Icahn ...

Home December 22, 2022
Home
News | Heart Failure

December 16, 2022 — For the longest time, clinicians have treated cardiovascular disease by focusing on diabetes and ...

Home December 16, 2022
Home
News | Heart Failure

December 15, 2022 — Soon after cholesterol and fat start depositing on the lining of the blood vessels that supply your ...

Home December 15, 2022
Home
Subscribe Now