News | December 22, 2009

Menopause Linked to Harmful Changes in Blood Cholesterol


December 22, 2009 – A new study is the first to specifically identify the year immediately around a woman’s final menstrual period as the time of most adverse changes in the lipid profile in women. The study appears in the Dec. 15-22, 2009, print double issue of the Journal of the American College of Cardiology (JACC) and the Prevention and Outcomes Quarterly Focus Issue.

The new findings emphasize the need to closely monitor lipid profiles of premenopausal and perimenopausal women. Researchers also suggest encouraging proven lifestyle changes and therapeutic interventions to try to counter, and prevent, adverse changes in lipids.

The study authors said it has been hotly debated whether the jump in heart disease risk among post-menopausal women is a function of aging or a consequence of the menopausal transition and the associated loss of endogenous estrogen, or both.

The study followed 1,054 initially pre-menopausal or early perimenopausal women from diverse ethnic backgrounds. The study assessed changes in a wide variety of cardiovascular risk factors in relation to a women’s final menstrual period. Only total cholesterol, low-density lipoprotein cholesterol (LDL or “bad” cholesterol) and its protein carrier (apoB) increased substantially around the time of a woman’s final menstrual period, consistent with menopause-induced changes.

These unique increases, which were independent of age and other cofounders, occurred in women of all weight levels and were similar across all ethnic groups, suggesting menopause has a uniform influence on lipids. Researchers found no changes in inflammatory or anti-coagulation factors, blood pressure, or insulin and glucose related to a woman’s final menstrual period; instead, these risk factors were consistent with a linear model, indicative of chronological aging.

Participants in this nine-year study ranged in age from 42 to 52 years, were not taking hormone therapy before menopause, were free of stroke, heart disease and diabetes at entry, and were followed annually and experienced their final menstrual period during follow-up.

For more information: content.onlinejacc.org

Related Content

First Patient Enrolled in U.S. Arm of ALIVE Pivotal Heart Failure Trial
News | Heart Failure| October 17, 2017
October 17, 2017 — BioVentrix Inc. recently announced enrollment of the first patient in the U.S.
Appropriate Use Criteria Published for Valvular Heart Disease Imaging Tests
News | Clinical Decision Support| October 16, 2017
The American College of Cardiology (ACC), along with several partnering societies, recently released appropriate use...
Videos | Cardiovascular Ultrasound| October 12, 2017
Sharon Mulvagh, M.D., FRCPC, FACC, FAHA, FASE, professor, Division of Cardiology, Department of Medicine, Dalhouse Un
Low Mortality and Stroke Risks Displayed for Minimally Invasive Aortic Valve Replacements
News | Heart Valve Technology| October 11, 2017
An analysis of more than 1,000 minimally invasive aortic valve replacements and more than 400 additional associated...
SunTech Medical Receives Third-Party Validation of CT40 BP Spot-Check Device
News | Blood Pressure Monitor| October 11, 2017
October 11, 2017 — The CT40 spot-check device from SunTech Medical has received third-party validation for...
New Evaluation Sends Low-Risk ER Chest Pain Patients Home Sooner
News | Cardiac Diagnostics| October 10, 2017
A new evaluation to determine whether emergency room patients with chest pain can go home and follow up with their...
News | Pharmaceuticals| October 04, 2017
October 4, 2017 — MyoKardia Inc.
Medtronic Announces Post-Market Study for CoreValve Evolut Pro System
News | Heart Valve Technology| October 02, 2017
Medtronic plc recently announced a new post-market clinical study to evaluate its CoreValve Evolut Pro valve in...
Majority of High-Risk Stroke Patients Not Being Screened for Common Risk Factors
News | Stroke| September 28, 2017
September 28, 2017 — New research revealed that on average, more than 75 percent of people aged 65 and older worldwid
BioCardia Announces 12-Month Results from TRIDENT Trial of Stem Cell Delivery System
News | Stem Cell Therapies| September 26, 2017
BioCardia Inc. recently announced 12-month results from the Phase II TRIDENT clinical trial, conducted by the...
Overlay Init