News | Cardiac Diagnostics | May 01, 2017

Non-O Blood Groups Associated With Higher Risk of Heart Attack

European study finds non-O blood groups have a 9 percent increased risk of coronary and cardiovascular events

Non-O Blood Groups Associated With Higher Risk of Heart Attack

May 1, 2017 — Having a non-O blood group is associated with a higher risk of heart attack, according to research presented at Heart Failure 2017 and the 4th World Congress on Acute Heart Failure, April 29-May 2 in Paris, France.

Lead author Tessa Kole, a Master’s degree student at the University Medical Centre Groningen, the Netherlands, said: “It has been suggested that people with non-O blood groups (A, B, AB) are at higher risk for heart attacks and overall cardiovascular mortality, but this suggestion comes from case-control studies which have a low level of evidence. If this was confirmed it could have important implications for personalized medicine.”

The current study was a meta-analysis of prospective studies reporting on O and non-O blood groups, and incident cardiovascular events including myocardial infarction (heart attack), coronary artery disease, ischemic heart disease, heart failure, cardiovascular events and cardiovascular mortality.

The study included 1,362,569 subjects from 11 prospective cohorts, described in nine articles. There were a total of 23,154 cardiovascular events. The researchers analyzed the association between blood group and all coronary events, combined cardiovascular events and fatal coronary events.

The analysis of all coronary events included 771,113 people with a non-O blood group and 519,743 people with an O blood group, of whom 11,437(1.5 percent) and 7,220 (1.4 percent) suffered a coronary event, respectively. The odds ratio (OR) for all coronary events was significantly higher in carriers of a non-O blood group, at 1.09 (95 percent confidence interval [CI] of 1.06–1.13).

The analysis of combined cardiovascular events included 708,276 people with a non-O blood group and 476,868 people with an O blood group, of whom 17,449 (2.5 percent) and 10,916 (2.3 percent) had an event, respectively. The OR for combined cardiovascular events was significantly higher in non-O blood group carriers, at 1.09 (95 percent CI 1.06–1.11).

The analysis of fatal coronary events did not show a significant difference between people with O and non-O blood groups.

“We demonstrate that having a non-O blood group is associated with a 9 percent increased risk of coronary events and a 9 percent increased risk of cardiovascular events, especially myocardial infarction,” said Kole.

The mechanisms that might explain this risk are under study. The higher risk for cardiovascular events in non-O blood group carriers may be due to having greater concentrations of von Willebrand factor, a blood-clotting protein that has been associated with thrombotic events. Further, non-O blood group carriers, specifically those with an A blood group, are known to have higher cholesterol. And galectin-3, which is linked to inflammation and worse outcomes in heart failure patients, is also higher in those with a non-O blood group.

Kole said, “More research is needed to identify the cause of the apparent increased cardiovascular risk in people with a non-O blood group. Obtaining more information about risk in each non-O blood group (A, B, and AB) might provide further explanations of the causes.”

She concluded, “In future, blood group should be considered in risk assessment for cardiovascular prevention, together with cholesterol, age, sex and systolic blood pressure. It could be that people with an A blood group should have a lower treatment threshold for dyslipidemia or hypertension, for example. We need further studies to validate if the excess cardiovascular risk in non-O blood group carriers may be amenable to treatment.”

For more information: www.escardio.org

Related Content

Study Shows Multiple Benefits of Patient-to-Patient Connectivity in Familial Chylomicronemia Syndrome
News | Cardiac Diagnostics | August 07, 2018
Akcea Therapeutics Inc., an affiliate of Ionis Pharmaceuticals Inc., announced the publication of results from the...
Being Overweight May Change Young Adults' Heart Structure, Function
News | Cardiac Diagnostics | August 03, 2018
Even as a young adult, being overweight may cause higher blood pressure and thicken heart muscle, setting the stage for...
High Intensity Exercise in Teenagers Could Ward Off Heart Disease

Ultrasound image of the carotid artery. Lines in yellow were used to determine arterial diameter and stretching before and following exercise.

News | Cardiac Diagnostics | July 16, 2018
New research published in Experimental Physiology has indicated potential differences in heart health benefits of...
News | Cardiac Diagnostics | June 14, 2018
A team of researchers says it has linked sensitivity to an allergen in red meat to the buildup of plaque in the...
The blood of patients with familial chylomicronemia syndrome (FCS) can appear milky in color (lipemic) due to the buildup of fat in their body. Image courtesy of Akcea Therapeutics.

The blood of patients with familial chylomicronemia syndrome (FCS) can appear milky in color (lipemic) due to the buildup of fat in their body. Image courtesy of Akcea Therapeutics.

 

Feature | Cardiac Diagnostics | May 07, 2018 | Steven D. Freedman, M.D., Ph.D.
 
Male Triathletes May Be Putting Their Heart Health at Risk
News | Cardiac Diagnostics | January 09, 2018
Competitive male triathletes face a higher risk of a potentially harmful heart condition called myocardial fibrosis,...
ERT Acquires iCardiac Technologies
News | Cardiac Diagnostics | December 19, 2017
ERT recently announced it has acquired iCardiac Technologies, a provider of centralized cardiac safety and respiratory...
Overlay Init