News | PET-CT | November 01, 2016

Optical and PET/CT Probes Detect Early Signs of Atherosclerosis

The activity-based probes image the vascular inflammation involved in plaque formation

PET/CT, atherosclerotic plaque detection, Stanford University

Application of dual-modality optical and PET/CT activity-based probe in experimental carotid inflammation model. Coronal noninvasive PET/CT scans of (A) healthy and (B) diseased mice with and without ligated carotid arteries respectively. Inset images show optical ex vivo florescence imagining of (A) healthy and (B) diseased carotid arteries.  PET/CT and optical images courtesy of Xiaowei Ma, Toshinobu Saito and Nimali Withana.

November 1, 2016 — Researchers at Stanford University have demonstrated for the first time the use of a dual optical and positron emission tomography/computed tomography (PET/CT) activity-based probe to detect atherosclerotic plaques. The study is published in the October issue of The Journal of Nuclear Medicine.

Atherosclerosis is largely an asymptomatic disease where plaques develop over decades and symptoms do not appear until greater than 70 percent of a vessel is occluded. This results in significant risk of severe cardiovascular events such as stroke or myocardial infractions, highlighting the need for early, non-invasive diagnosis of the disease.

Matthew Bogyo, Ph.D., one of the lead authors of the study explained, “This collaborative study with Zhen Cheng, Ph.D., and Michael McConnell, M.D., provides evidence that these probes have potential benefits for non-invasive imaging of atherosclerotic plaque inflammation, potentially leading to the application of this probe in the clinic to help identify patients at high risk of developing premature atherosclerosis.”

Macrophages are cellular mediators of vascular inflammation and are involved in the formation of atherosclerotic plaques. These immune cells secrete proteases such as matrix metalloproteinases and cathepsins that contribute to disease formation and progression. In this study, activity-based probes (ABPs) targeting cysteine cathepsins were used in mouse models of atherosclerosis to non-invasively image activated macrophage populations using both optical and PET/CT methods. The probes were also used to topically label human carotid plaques, demonstrating similar specific labeling of activated macrophage populations. 

The study demonstrates that ABPs targeting the cysteine cathepsins offer a rapid, non-invasive way to image atherosclerotic disease progression and plaque vulnerability.

Bogyo noted, “What’s novel about this is the fact that these probes provide accurate detection of lesions undergoing high levels of inflammatory activity and extracellular matrix remodeling. They not only enable early disease detection, they can provide real-time monitoring of therapeutic responses and clinical drug efficacy.”

He sees broader uses for the probes in the future. “The probes show efficacy in a variety of imaging modalities, including fluorescence, PET/CT, and topical application of the probe to fresh frozen murine and human tissue sections. These tools further demonstrate that the future of molecular imaging and nuclear medicine will be focused on agents that allow specific targeting of disease-associated proteins or markers that allow monitoring of disease onset, progress and response to therapeutic agents,” he said.

For more information: www.jnm.snmjournals.org

Related Content

Videos | Cardiac Imaging | September 10, 2018
Leslee Shaw, Ph.D., professor of cardiology and rad
Arterys collaborated with GE Healthcare to create the ViosWorks software to cardiac MRI analysis.

Arterys collaborated with GE Healthcare to create the ViosWorks software. The software integrates artificial intelligence to speed workflow and perform a full 3-D chest volume scan with myocardium motion, blood flow, time and fully automated quantification.

Feature | Cardiac Imaging | March 30, 2018 | Jeff Zagoudis
Magnetic resonance imaging (MRI) for cardiac assessment provides a radiation-free alternative to other commonly used
New Policy Decisions Give Millions Access to HeartFlow FFRct Analysis
News | Cardiac Imaging | February 01, 2018
February 1, 2018 – HeartFlow announced that seven new commercial payers issued positive medical policies covering the
Clear detail of the in-stent restenosis can be seen in this image from the new high-resolution Canon Precision CT system. RSNA 2017, #RSNA2017, #RSNA17

Clear detail of the in-stent restenosis can be seen in this image from the new high-resolution Canon Aquilion Precision CT system.

Feature | Cardiac Imaging | January 23, 2018 | Dave Fornell
Medical imaging plays a key role in cardiology, and most of the newest radiology technology advances are first unveil
Philips Introduces Technology Maximizer Program for Imaging Equipment Upgrades
Technology | Cardiac Imaging | January 17, 2018
Philips recently announced the launch of Technology Maximizer, a cross-modality program designed to boost the clinical...
Videos | Cardiac Imaging | December 29, 2017
ITN and DAIC Editor Dave Fornell takes a tour of some of the most interesting new medical imaging technologies on the
Siemens Healthineers Introduces Share360 Tailored Service Portfolio
News | Cardiac Imaging | November 10, 2017
To address the specific needs of medical imaging clinical engineering departments nationwide, Siemens Healthineers has...
HeartFlow's FFR-CT (FFRct) analysis software can create a virtual FFR to assess coronary artery disease.

HeartFlow's FFR-CT analysis software uses a computed tomography scan and supercomputing fluid dynamics software to create a noninvasive, virtual FFR map of the entire coronary artery tree to determine the flow-limiting severity of ant lesions. 

News | Cardiac Imaging | November 06, 2017
November 6, 2017 – The Centers for Medicare & Medicaid Services (CMS) has finalized a New Technology Ambulatory P
Philips Announces Findings of Patient Experience in Imaging Research
News | Cardiac Imaging | October 24, 2017
Philips recently announced the key findings of its research focused on the patient experience in diagnostic imaging...
Overlay Init