News | April 26, 2010

Pulmonary Arterial Hypertension Therapy Hits Market

A new formulation of Epoprostenol for Injection is stable at room temperature for up to 24 hours when diluted.

April 22, 2010 — An improved formulation of epoprostenol for the treatment of primary pulmonary arterial hypertension (PAH) and pulmonary hypertension is now commercially available.

Actelion Pharmaceuticals US, Inc., recently made the announcement regarding epoprostenol for injection, a therapy approved by the U.S. Food and Drug Administration (FDA) for the treatment of moderate to severe PAH, a chronic, life-threatening disorder characterized by abnormally high blood pressure in the arteries between the heart and lungs of an affected individual..

Simultaneously, the company has launched the PROSPECT registry, a multicenter, observational, U.S. registry that will provide additional clinical experience on patients being treated with epoprostenol for Injection.

Unlike other epoprostenol formulations, epoprostenol for injection is stable at room temperature for up to 24 hours when diluted and put into the pump for administration, eliminating the need for ice packs.

Accredo Health Group Inc., a wholly owned subsidiary of Medco Health Solutions Inc., will serve as the sole specialty pharmacy provider of epoprostenol for injection.

"Patients with late-stage PAH are extremely ill and have little energy, so a therapy that is convenient could make a big difference in their daily lives," said Vallerie McLaughlin, M.D., professor and director of the pulmonary hypertension program at the University of Michigan. "In addition, the PROSPECT registry will be valuable in enhancing our understanding of patient response to epoprostenol for injection, and will help physicians provide the most appropriate care to patients."

Epoprostenol for injection is indicated for the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in New York Heart Association Class III and Class IV patients who do not respond adequately to conventional therapy. Epoprostenol for injection can be reconstituted with either sterile water for injection or sodium chloride 0.9 percent injection, eliminating the need for drug-specific dilutions.

For more information:

Related Content

Pfizer Announces Positive Topline Results from Phase 3 ATTR-ACT Study
News | Pharmaceuticals | April 06, 2018
Pfizer Inc. announced that the Tafamidis Phase 3 Transthyretin Cardiomyopathy (ATTR-ACT) study met its primary endpoint...
Humanetics Presents Data on Drug to Protect Cardiac Cells From Space-Like Radiation

Photo from NASA

News | Pharmaceuticals | February 01, 2018
February 1, 2018 –Humanetics Corporation (Humanetics) has recently completed two research studies funded by the Natio
Xarelto Significantly Reduces Major Cardioavascular Events in Stable CAD and PAD Patients
News | Pharmaceuticals | October 18, 2017
October 18, 2017 — Results from the pivotal Phase 3 COMPASS study found that the...
News | Pharmaceuticals | October 04, 2017
October 4, 2017 — MyoKardia Inc.
News | Pharmaceuticals | September 12, 2017
September 12, 2017 — Inclisiran lowers low-density lipoprotein (LDL, or “bad”) cholesterol for up to one year in pati
Merck Announces Results of REVEAL Outcomes Study of Anacetrapib
News | Pharmaceuticals | September 11, 2017
Merck and researchers in the Clinical Trial Service Unit at the University of Oxford announced the publication and...
Statins Associated With Improved Heart Structure and Function
News | Pharmaceuticals | May 26, 2017
Statins are associated with improved heart structure and function, according to research presented at EuroCMR 2017, May...
Feature | Pharmaceuticals | May 16, 2017
May 16, 2017 – Results of a groundbreaking clinical trial demonstrate the effectiveness of a novel, fast-acting nasal
Prescribing Patterns Change Following Direct Marketing Restrictions
News | Pharmaceuticals | May 05, 2017
A study of how policies restricting pharmaceutical promotion to physicians affect medication prescribing found...
EBBINGHAUS study, evolocumab, repatha, statin therapy, cognitive issues, ACC.17 study
News | Pharmaceuticals | April 03, 2017
There is no evidence that adding a new cholesterol-lowering drug to treatment with a statin causes memory loss or other...
Overlay Init