News | Cardiac Diagnostics | September 13, 2016

Researchers Suspect MicroRNAs as Potential Link Between Obesity and Heart Disease

Obese study participants showed alterations in levels of specific circulating microRNAs compared to control group

September 13, 2016 — Results from a new study suggest that small molecules known as microRNAs may be part of the pathway connecting inflammation with increased heart disease risk in obese people. The new findings were presented at the American Physiological Society’s Inflammation, Immunity and Cardiovascular Disease conference, Aug. 24-27 in Westminster, Colo.

MicroRNAs — molecules that are found throughout the body’s tissues and fluids, such as blood — help regulate gene expression tied to health and disease. Because recent research has shown that microRNAs are key players in the regulation of inflammation and vascular health, researchers from the University of Colorado, Boulder, wanted to know whether obesity is associated with any changes in microRNA levels.

“Studying microRNAs circulating in the blood has the potential to increase our understanding of the higher risk for cardiovascular problems that are associated with obesity,” said study co-author Jaime Hijmans, a predoctoral research fellow in the Integrative Vascular Biology Laboratory at the University of Colorado, Boulder. “MicroRNAs might also prove to be useful as biomarkers of cardiovascular health in obese adults.”

For the study, the researchers examined levels of four microRNAs circulating in the blood of 15 normal weight and 15 obese people. The study participants were between the ages of 47 and 64 and were sedentary nonsmokers who were free of heart disease and had normal blood pressure.

The researchers found that the obese study participants had alterations in the levels of specific circulating microRNAs involved in regulating vascular inflammation, a key element of cardiovascular disease risk. These changes were seen in otherwise healthy obese adults, suggesting that obesity without other risk factors negatively affects the body’s mechanisms for regulating inflammation.

For more information: www.the-aps.org/inflammation

Related Content

Male Triathletes May Be Putting Their Heart Health at Risk
News | Cardiac Diagnostics| January 09, 2018
Competitive male triathletes face a higher risk of a potentially harmful heart condition called myocardial fibrosis,...
ERT Acquires iCardiac Technologies
News | Cardiac Diagnostics| December 19, 2017
ERT recently announced it has acquired iCardiac Technologies, a provider of centralized cardiac safety and respiratory...
New Study Suggests Protein Could Protect Against Coronary Artery Disease

Patients with no obstructed blood flow in the coronary arteries had higher levels of CXCL5 (blue) compared to patients with moderate levels (green) or lower levels (yellow) of CXCL5, who had increased severity of coronary obstructions (indicated by the arrows). Credit: Schisler lab

News | Cardiac Diagnostics| December 07, 2017
December 7, 2017 — The buildup of plaque in the heart’s arteries is an unfortunate part of aging.
E-cigarettes Most Likely to be Used by Alcohol Drinkers and Former Cigarette Smokers, at American Heart Association (AHA), #AHA2017.
News | Cardiac Diagnostics| December 06, 2017
December 6, 2017 — Electronic cigarettes are more frequently used by people who recently quit smoking and alcohol dri
Lack of sleep may cause heart disease in older women. American heart Association, #AHA2017
News | Cardiac Diagnostics| December 06, 2017
December 6, 2017 — Older women who do not get enough sleep were more likely to have poor cardiovascular health, accor
New Tool Predicts Risk of Heart Attack in Older Surgery Patients
News | Cardiac Diagnostics| December 05, 2017
A tool designed to more accurately predict the risk of heart attack in older patients undergoing non-cardiac surgery...
EPIC Norfolk prospective population study showed any physical activity is better than none in older adults in preventing cardiovascular disease.

The EPIC Norfolk prospective population study showed any physical activity is better than none in older adults in preventing cardiovascular disease.

News | Cardiac Diagnostics| November 24, 2017
November 24, 2017 — Any physical activity in the elderly is better than none at all for reducing cardiovascular risk,
Analytics 4 Life Presents Clinical Data on Machine-Learned Cardiac Imaging Technology at TCT 2017
News | Cardiac Diagnostics| November 01, 2017
Analytics 4 Life announced it will be presenting new clinical data on the company's ongoing Coronary Artery Disease...
American Heart Association, Verily and AstraZeneca Launch One Brave Idea Science Innovation Center
News | Cardiac Diagnostics| October 20, 2017
The American Heart Association, Verily and AstraZeneca announced the opening of the One Brave Idea Science Innovation...
The Role of Telomere Length in Cardiovascular Risk Assessment
Feature | Cardiac Diagnostics| October 19, 2017 | Nanette H. Bishopric, M.D., FACC, FAHA
A new area of DNA testing involving telomere length may enhance a patient’s cardiovascular disease risk stratificatio
Overlay Init