News | September 22, 2008

SSRI Drug Therapy Shown to Improve Depression, Morbidity in Heart Failure Patients

September 23, 2008 – Results of the SADHART (Safety and Efficacy of Sertraline for Depression in Patients with CHF) clinical trial were presented yesterday at the 12th Annual Scientific Meeting of the Heart Failure Society of America (HFSA) in Toronto, presenting evidence of how treatment can improve depression and morbidity in heart failure.
Christopher O'Connor, M.D., (professor of medicine and director, Duke Heart Center, Duke University) highlighted the results of treating patients who suffer from heart failure and depression with the drug Sertraline, which is a selective serotonin-reuptake inhibitor (SSRI) anti-depressant with psycho-supportive therapy. It was used to evaluate the effectiveness in improving mood disorders, and the results also showed a decrease in mortality with heart failure patients.
"For years, the only anti-depressive treatments were in the form of tricyclics, which were associated with instances of sudden death and arrhythmias in patients being treated for both chronic heart failure and mood disorders," said Barry Greenberg, M.D., HFSA president, and professor of medicine, and director, Advanced Heart Failure Treatment Program, University of California, San Diego. "Finding a safe and effective means to treat depression and lower the fatality rates in heart failure patients would mark a major advancement for the medical community, and bring relief and a renewed hope for cardiology patients."
Dr. O'Connor explained that the trial was designed to test the hypothesis that heart failure patients treated with Sertraline plus psycho-supportive therapy will have an improvement in symptoms of depression and a lower rate of mortality and cardiovascular events as compared to psycho-supportive therapy alone. This larger trial was in response to a similar trial, which had showed promising results that Sertraline not only proved to be safe and effective, but tended to reduce morbidity and mortality and improve depression in heart failure patients. This larger trial SADHART was a randomized, double-blind, placebo-controlled study that investigated the use of Sertraline as an effective way to treat patients who presented as having a major depressive disorder (MDD) and a diagnosis of heart failure. The trial, sponsored by the National Institute of Mental Health, studied a population of 500 men and women 45 years of age or older who were randomized to Sertraline or placebo group for a 12-week acute treatment phase. All patients were followed for six months. Quality of life and physiologic parameters, as well as pro-inflammatory and HF biomarkers were also obtained.
"Sertraline has a very favorable pharmacological profile, in terms of adverse reactions with other drugs, which is crucial because heart failure patients often take up to 12 different medications. Our study aims to test whether depression, which has been an ongoing topic of research since the 1920s, can be greatly reduced through the use of SSRI's like Sertraline or by psycho-supportive therapy," said Dr. O'Connor, who added that patients with heart failure and depression are twice as likely to die from cardiac complications than patients who suffer from heart failure. "We hope that this presentation demonstrates the importance of identifying and treating depression in heart failure patients must continually be examined. We hope to soon conduct similar trials to SADHART, but with a long-term period of follow-up in similar study populations."

For more information: www.hfsa.org/, www.abouthf.org/

Related Content

Farxiga Reduces Heart Failure Hospitalization, Cardiovascular Death for Type 2 Diabetes
News | Pharmaceuticals | November 15, 2018
AstraZeneca announced positive full results from the DECLARE-TIMI 58 cardiovascular (CV) outcomes trial (CVOT) for...
Vascepa and Statins Significantly Reduce Cardiovascular Events in the REDUCE-IT trial. #AHA #AHA18 #AHA2018
News | Pharmaceuticals | November 13, 2018
A study in the current edition of the New England Journal of Medicine shows that a particular treatment significantly...
Evolocumab Benefits High-Risk Patients With Established Cardiovascular and Chronic Kidney Disease
News | Pharmaceuticals | October 31, 2018
Amgen announced a new Repatha cardiovascular outcomes study (FOURIER) analysis evaluating the effects of Repatha (...
Jardiance Improves Life Expectancy for Adults With Type 2 Diabetes and Cardiovascular Disease
News | Pharmaceuticals | October 11, 2018
Novel results from the landmark EMPA-REG OUTCOME trial suggest that treatment with Jardiance positively impacts life...
Effect of Daily Aspirin on First-Time Heart Attack and Stroke Risk Inconclusive
News | Pharmaceuticals | September 04, 2018
The jury is still out on whether people at moderate risk of a first heart attack or stroke should take daily aspirin to...
Blood Pressure and Cholesterol-lowering Drugs Continue to Improve Survival After a Decade
News | Pharmaceuticals | August 27, 2018
Blood pressure and cholesterol-lowering drugs continue to improve survival in patients with hypertension after more...
Pfizer Announces Positive Topline Results from Phase 3 ATTR-ACT Study
News | Pharmaceuticals | April 06, 2018
Pfizer Inc. announced that the Tafamidis Phase 3 Transthyretin Cardiomyopathy (ATTR-ACT) study met its primary endpoint...
Humanetics Presents Data on Drug to Protect Cardiac Cells From Space-Like Radiation

Photo from NASA

News | Pharmaceuticals | February 01, 2018
February 1, 2018 –Humanetics Corporation (Humanetics) has recently completed two research studies funded by the Natio
Xarelto Significantly Reduces Major Cardioavascular Events in Stable CAD and PAD Patients
News | Pharmaceuticals | October 18, 2017
October 18, 2017 — Results from the pivotal Phase 3 COMPASS study found that the...
Overlay Init