News | February 03, 2014

Study Shows Risk of VTE in Chemotherapy Patients, Recommends Thromboprophylaxis

February 3, 2014 — A large-scale analysis assessing the real-world risk of venous thromboembolism (VTE) in chemotherapy patients shows a greater occurrence of VTE than identified in clinical trials. Risk progressively increases during the year following treatment initiation, according to the report. 
 
The study shows outpatients receiving chemotherapy are at high risk of developing VTE and of major bleeding complications, especially those with pancreas, stomach and lung cancer. The authors conclude thromboprophylaxis should be considered for such patients after carefully assessing risks and benefits. 
 
The Oncologist published the study, which is led by Gary H. Lyman, M.D., Duke University School of Medicine and Duke Cancer Institute, in collaboration with scientists from Sanofi and King’s College Hospital in London, U.K. The team of researchers hypothesized there is a definable high-risk cohort of patients who would benefit from thromboprophylactic treatment for VTE, and that the scope of this risk warrants consideration for the use of prophylaxes such as low- and ultra-low-molecular-weight heparins.
 
The study involved a random sample of approximately 27,500 patients with high-VTE-risk cancer types, such as lung, pancreas, stomach, colon/rectum, bladder or ovary, who had undergone chemotherapy. The group retrospectively evaluated the patients’ VTE risk, risk of bleeding and economic as a result of the disease.
 
The risk of VTE increased over time, with a greater percentage of patients developing the complication at 12 months after initiation of chemotherapy than at three months; this held true across three definitions of VTE considered. According to definition A, the least conservative of the three, VTE was most frequently observed in cancers of the pancreas, lung and stomach. The overall incidence of the complication was 13.5 percent at a year, with no indication of plateau or tapering at that time point. Patients with VTE showed a higher risk of major bleeding events in the year following chemotherapy initiation. According to definition A, that risk was 19.8 percent, compared with 9.6 percent in patients without VTE. These rates are higher than has been reported with anticoagulation use in clinical trials. Baseline healthcare costs of patients who would develop VTE were comparable to those who would not, and the costs of the VTE patients soared over the year following chemotherapy initiation. On average, patients with VTE had $110,719 in expenses compared with $76,804 for patients without VTE, a difference primarily accounted for by VTE-related inpatient, outpatient and emergency room expenses.
 
“Importantly, this observational study suggests that the observed rates of symptomatic VTE in real-world practice are considerably greater than reported in patients eligible for randomized clinical trials,” Lyman said. “Clinical oncologists need to be aware of the increased risk of this serious complication of cancer and cancer treatment, and when the risk is sufficiently great and the balance of benefits and harms acceptable, oncologists should consider prophylactic anticoagulation.”
 
For more information: www.theoncologist.com

Related Content

DISRUPT BTK Study Shows Positive Results With Lithoplasty in Calcified Lesions Below the Knee
News | Peripheral Artery Disease (PAD)| September 20, 2017
Shockwave Medical reported positive results from the DISRUPT BTK Study, which were presented at the annual...
Heart Failure Market to Surpass $16 Billion by 2026
News | Heart Failure| September 19, 2017
The heart failure space across the seven key markets of the U.S., France, Germany, Italy, Spain, the U.K. and Japan is...
Corindus Announces First Patient Enrolled in PRECISION GRX Registry
News | Robotic Systems| September 18, 2017
September 18, 2017 — Corindus Vascular Robotics Inc.
Two-Year ILLUMENATE Trial Data Demonstrate Efficacy of Stellarex Drug-Coated Balloon
News | Drug-Eluting Balloons| September 18, 2017
Philips announced the two-year results from the ILLUMENATE European randomized clinical trial (EU RCT) demonstrating...
Sentinel Cerebral Protection System Significantly Reduces Stroke and Mortality in TAVR
News | Embolic Protection Devices| September 18, 2017
September 18, 2017 – Claret Medical announced publication of a new study in the...
Marijuana Associated With Three-Fold Risk of Death From Hypertension
News | Hypertension| September 14, 2017
Marijuana use is associated with a three-fold risk of death from hypertension, according to research published recently...
Peter Schneider, M.D. presents late breaking clinical trial results at VIVA 17 in Las Vegas. Panelists (l to r) Krishna Rocha-Singh, M.D., Sean Lyden, M.D., John Kaufman, M.D., Donna Buckley, M.D.

Peter Schneider, M.D. presents late breaking clinical trial results at VIVA 17 in Las Vegas. Panelists (l to r) Krishna Rocha-Singh, M.D., Sean Lyden, M.D., John Kaufman, M.D., Donna Buckley, M.D.

Feature | Cath Lab| September 14, 2017
September 14, 2017 — Here are quick summaries for all the key late-breaking vascular and endovascular clinical trials
Medtronic Announces Japanese Regulatory Approval for In.Pact Admiral Drug-Coated Balloon
News | Drug-Eluting Balloons| September 13, 2017
Medtronic plc announced that the In.Pact Admiral Drug-Coated Balloon (DCB) received approval from the Japanese Ministry...
PQ Bypass Reports Positive Results for Detour System in Patients With Long Femoropopliteal Blockages
News | Peripheral Artery Disease (PAD)| September 13, 2017
A subset analysis of the DETOUR I clinical trial showed promising safety and effectiveness results of PQ Bypass’ Detour...
News | Cardiac Diagnostics| September 12, 2017
Contracting shingles, a reactivation of the chickenpox virus, increases a person’s risk of stroke and heart attack,...
Overlay Init