News | February 11, 2013

VNT Poised for Breakthrough Interventional Applications With Its Next-Generation Drug-Coated-Balloon Technology

February 11, 2013 — Vascular Nanotransfer Technologies (VNT) says it has developed the industry’s most versatile drug-coated-balloon (DCB) platform designed to deliver a wide variety of drugs for best-in-class DCB applications.

“We are the first drug-coated-balloon technology capable of nano-encapsulation of different antiproliferative drugs designed to achieve optimal therapeutic tissue levels over time,” says VNT’s CEO, John A. Williams. “We are truly the world’s first drug ‘eluting’ balloon platform.”

While Williams declined at this time to disclose the company’s initial application of its DCB platform technology “because we are talking to a number of strategics,” he explained that the company is able to produce nanocrystals of a wide variety of drugs that are encapsulated within organic nanocarriers and uniformly deposited on the surface of VNT’s balloon.

Prior to VNT, Williams was president and CEO of Ovatech LLC. Previously, he was CEO of Cappella and Physiometrix. Earlier in his career, he was employed by Medtronic (Andover Medical) and Johnson &?Johnson. A serial entrepreneur with both operational and fundraising successes, Williams has: led a successful IPO; raised more than $80 million for his companies; and sold three of his companies for handsome profits.

According to Williams, VNT is focused solely on drug-coated balloons, which are emerging as the ideal therapeutic tool for patients with coronary in-stent restenosis (ISR) and peripheral vascular disease. However, despite the success of first-generation DCBs in clinical trials, they exhibit significant limitations related to the precision of drug delivery and tissue retention, raising concerns about overall vascular safety. There is a need for the development of reliable coatings that allow for controlled drug delivery at a lower dose and minimal dislodgement of the coating into the distal vessel.

“There are currently no DCBs approved for use in the U.S.,” says Williams. “While current DCBs show great promise, there are regulatory?concerns about the limitations of balloon coating technologies to maintain a reproducible dose throughout the balloon length and thus precisely transfer a drug to the targeted blood vessel tissue. VNT’s proprietary balloon coating addresses these limitations.”

VNT’s proprietary nanocoating technology makes possible DCBs that are designed with enhanced drug delivery and performance characteristics compared to currently marketed DCBs, according to Williams. “We expect to begin site enrollment imminently for VNT’s First-In-Man clinical trial with our initial application, which we cannot disclose at this time.”

There are currently no DCBs approved for use in the U.S.  While current DCBs show great promise, there are FDA?concerns about the limitations of balloon coating technologies to maintain a reproducible dose throughout the balloon length and thus precisely transfer a drug to the targeted blood vessel tissue. VNT’s proprietary balloon coating addresses these limitations; in vivo data are extremely promising.

VNT’s Scientific Advisory Board is comprised of three eminent cardiologists: Juan F. Granada, M.D., executive director and chief scientific officer, Skirball Center for Cardiovascular Research at the Cardiovascular Research Foundation (CRF); and, assistant professor of medicine, Cardiology, Columbia University College of Physicians and Surgeons; Gregg W. Stone, M.D., director, Cardiovascular Research and Education, Center for Interventional Vascular Therapy (CIVT) at New York Columbia-Presbyterian Hospital and Cardiovascular Research Foundation (CRF); professor of medicine, Columbia University Medical Center; and, Co-Director, annual “TCT” symposium; William A. Gray, M.D., Director, Endovascular Interventions, Center for Interventional Vascular Therapy (CIVT) at New York Columbia-Presbyterian Hospital; associate professor, Columbia University School of Medicine; reviewer: Journal of the American Medical Association (JAMA), Journal of the American College of Cardiology (JACC), and Circulation.

Related Content

News | Cath Lab | February 23, 2018
February 23, 2018 — CorFlow Therapeutics AG announced that the company will present new insights into the coronary mi
Teleflex Launches Next-Generation Sympro Elite and Expro Elite Snares
Technology | Cath Lab | February 07, 2018
Teleflex Inc. has announced 510(k) clearance by the U.S. Food and Drug Administration (FDA) and U.S. commercial launch...
SCAI Advocacy Committee Highlights Reimbursement Reform Efforts in 2017
News | Cath Lab | January 30, 2018
The Society for Cardiovascular Angiography and Interventions (SCAI) highlighted the efforts of its Advocacy Committee...
IAC Releases Cardiovascular Catheterization Accreditation Program
News | Cath Lab | January 25, 2018
January 25, 2018 – The Intersocietal Accreditation Commission (IAC) announced the release of its Cardiovascular Cathe
Videos | Cath Lab | January 04, 2018
Bernadette Speiser, BSN, MSN, CCRN, RCIS, a cardiac cath/EP nurse at Palo Alto Veterans Hospital, Palo Alto, Calif.,
FDA Initiates Class I Recall of Sterilmed Reprocessed Agilis Steerable Introducer Sheath
News | Cath Lab | January 04, 2018
The U.S. Food and Drug Administration (FDA) announced a Class I recall of Sterilmed’s Agilis Steerable Introducer...
The California Heart & Vascular Clinic in El Centro, Calif., treated the first post-FDA clearance patient with a DABRA atherectomy system. Athar Ansari, M.D.

The California Heart & Vascular Clinic in El Centro, Calif., treated the first post-FDA clearance patient with a DABRA system. 

Feature | Cath Lab | November 24, 2017 | Athar Ansari, M.D., FACC
As debates about the current state and future of healthcare rage in Congress, the media and healthcare settings acros
Videos | Cath Lab | November 08, 2017
Juan Granada, M.D., Cardiovascular Research Foundation president and chief executive officer, shares his insights on
Results of the ORBITA study found no difference in exercise time after six weeks in patients with stable angina who received percutaneous coronary intervention (PCI) versus a placebo treatment. TCT 2017
Feature | Cath Lab | November 06, 2017
November 6, 2017 – Results from ORBITA, a prospective multi-center randomized blinded placebo-controlled study, found
Overlay Init