There were many opinions on the duration of dual antiplatelet therapy (DAPT) highlighted at the 2016 American College of Cardiology (ACC.16) meeting. A general theme was DAPT prolongation and patient stratification, which was relevant to the recent release of the ACC and the American Heart Association’s (AHA) 2016 Focused Update in Duration of DAPT in Patients with Coronary Artery Disease (CAD). Although sessions at ACC.16 helped clarify the recent guidelines, questions still remain.